Name: Aimee Jaramillo-Lambert
Major Professor: JoAnne Engebrecht
Department: Molecular and Cellular Biology (College of Biological Sciences)
Lab Phone: (530)754-6032
Email: anjaramillo@ucdavis.edu
Web Site:
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BS -
University of California, Davis -
Genetics -
2003
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Research Interests
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To ensure that cells that arise from division have the correct complement and fidelity of DNA requires a highly coordinated process and a series of checkpoints. DNA damage or aneuploidy are sensed by conserved checkpoint pathways that signal for cells to induce arrest or send damaged cells into the apoptotic pathway. Meiotic checkpoint defects can lead to infertility or cancer. The checkpoints that exist in Caenorhabditis elegans are a DNA damage checkpoint, an S phase checkpoint, and a synapsis checkpoint. Failure of checkpoint function may result in the production of inviable or defective progeny, or the generation of germline tumors. My thesis project utilizes the unique features of C. elegans meiosis to study aspects of DNA replication, chromosome structure, and checkpoint function and the differences between these process in the two sexes (male vs. female).
Molecular and Cellular Biology Trainng Grant (2007-2009), Carl Storm Underrepresented Minority Fellowship (2006).
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Publications
Jaramillo-Lambert A, Ellefson M, Villeneuve AM, Engebrecht J. "Differential timing of S phases, X chromosome replication, and meiotic prophase in the C.elegans germ line," Dev Biol. 2007 Aug 1;308(1):206-21.
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