Lifeng Xu
Assistant Professor
lfxu@ucdavis.edu

Microbiology

Office
313 Briggs Hall
Office 530-752-3660
Lab 530-752-1088


Picture of Lifeng Xu
 
Degrees:
2000 PhD Princeton University Molecular Biology
1993 BS Fudan University Biology
Research Interests:

Telomeres are the protective nucleoprotein structures at the ends of linear eukaryotic chromosomes. Telomere dysfunction contributes to cancer progression and aging. Our laboratory employs molecular and cytological approaches to study telomere maintenance in human normal cells and cancer cells.
Department and Center Affiliations:
Microbiology
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology  
Genetics  
Graduate Groups not Housed in CBS:
Microbiology  
Publications: Last updated 9/22/2009
  • Xu, L and Blackburn, E.H. Human cancer cells harbor t-stumps, a distinct class of extremely short telomeres. Mol. Cell 28: 315-327 (2007)
  • Xu, L and Blackburn, E.H. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J. Cell Biol. 167: 819-830 (2004)
  • Ly, H.*, Xu, L.*, Rivera, M.A., Parslow, T.G., Blackburn, E.H. A role for a novel ‘transpseudoknot’ RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev. 17:1078-1083 (2003)
  • Kim, M., Xu, L., Blackburn, E.H. Catalytically active human telomerase mutants with allele-specific biological properties. Exp. Cell Res. 288:277-287 (2003)
  • Comolli, L.R., Smirnov, I., Xu, L., Blackburn, E.H., James, T.L. A molecular switch underlies a human telomerase disease. Proc. Natl. Acad. Sci. USA. 99: 16998-17003 (2002)
  • Tao, W., Pennica, D., Xu, L., Kalejta, R.F., Levine A.J. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev. 15: 1796-1807 (2001)
  • Xu, L., Corcoran, R.B., Welsh, J.W., Pennica, D., Levine A.J. WISP-1 is a Wnt-1 and ß-catenin responsive oncogene. Genes Dev. 14: 585-595 (2000).
Laboratory Personnel:
341 Briggs Hall

Sara Yuhua Zong, Junior Specialist