Su-Ju Lin
Assitant Professor
slin@ucdavis.edu

Microbiology

Office
342 BRIGGS HALL
(530) 754-6081

Lab
(530) 754-6082


Picture of Su-Ju Lin
 
Degrees:
2003 Postdoctoral Fellow-Massachusetts Institute of Technology Biology
1997 PhD Johns Hopkins University Toxicological Sciences
1991 BA National Taiwan University Environmental Health Sciences
Research Interests:

Molecular mechanisms of Calorie Restriction and Aging
Awards:
1997-1998 Anna Fuller Fund for Cancer Research Fellowship
1999-2002 Individual National Research Service Award
2004-2008 Ellison Medical Foundation New Scholar in Aging
Department and Center Affiliations:
UC Davis Cancer Center
Professional Societies:
Genetic Society of America
The American Society for Biochemistry
CBS Graduate Group Affiliations:
Genetics  
Graduate Groups not Housed in CBS:
Microbiology  
Publications:
  • S. -J. Lin, P. Defossez and L. Guarente. (2000) Life span extension by calorie restriction in S. cerevisiae requires SIR2 and NAD. Science 289:2126-8.
  • S. -J. Lin, M. Kaeberlein, A. A. Andalis, L. A. Sturtz, P.-A. Defossez, V. C. Culotta, G. R. Fink and L. Guarente (2002) Calorie restriction extends life span by shifting carbon toward respiration. Nature 418:344-348.
  • S. -J. Lin and L. Guarente (2003) NAD, a metabolic regulator of transcription, longevity and diseases. Current Opinion in Cell Biology 15:241-246.
  • S. -J. Lin, E. Ford, M. Haigis, G. Liszt and L. Guarente (2004) Calorie restriction extends life span by lowering the NADH levels. Genes and Development 18:12-16.
  • D. Lamming, M. Latorre, O. Medvedik, S. N. Wong, F. A. Tsang, C. Wang, S.-J. Lin* and D. A. Sinclair* (2005) HST2 mediates SIR2-independent lifespan extension by calorie restriction. Science 309:1861-64
  • L. Bordone, M. C. Motta, F. Picard, A. Robinson, U. S. Jhala, J. Apfeld, T. McDonagh, M. Lemieux, M. McBurney, E. J. Easlon, S.-J. Lin, and L. Guarente (2005) Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ?-cells. PLoS Biol 4(2):e31.
  • S. -J. Lin (2006) Molecular Mechanisms of Longevity regulation and calorie restriction. In Nutritional Genomics (Editors: J. Kaput and R. L Rodriguez), pp207-219. John Wiley and Sons, Inc., Hoboken, New Jersey.
  • S. -J. Lin and L. Guarente (2006) Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2, e33
  • D. A. Sinclair, S. -J. Lin and L. Guarente (2006) Life-span extension in yeast. Science 312, 195-197.
  • E. Easlon, F. Tsang, I. Dilova, C. Wang, S-P Lu, C. Skinner and S-J Lin. (2007) The Dihydrolipoamide Acetyltransferase Is A Novel Metabolic Longevity Factor And Is Required For Calorie Restriction Mediated Life Span Extension. J. Biol.Chem. 282:6161-71
  • I. Dilova, E. Easlon and S.-J. Lin (2007) Calorie Restriction and the Nutrient Sensing Signaling Pathways. Cell Mol Life Sci, 64:752-767.
  • S. -J. Lin and D. Sinclair (2008) Molecular mechanism of aging - insights from yeast. In The Molecular Biology of Aging (Editors: L. Guarente, L. Partridge, and D.Wallace), pp483-516. Cold Spring Harbor Laboratory Press
  • E. Easlon, F. Tsang, C. Skinner, C. Wang and S-J Lin (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction mediated life span extension in yeast. Genes and Development 22:931-944
  • D. Chen, J. Bruno, E. Easlon, S.-J. Lin, F. Alt and L. Guarente (2008) Tissue-specific Regulation of SIRT1 by Calorie Restriction. Genes and Development 22:1753-7
  • Single sample extraction protocol for quantification of NAD and NADH redox states in Saccharomyces cerevisiae (2008) J. L. Sporty, Md. M. Kabir, K. W. Turteltaub, T. Ognibene, S.-J. Lin, and G. Bench. Journal of Separation Science (in press)
  • J. L. Sporty, Md. M. Kabir, K. W. Turteltaub, T. Ognibene, S.-J. Lin, and G. Bench. (2008) Single sample extraction protocol for quantification of NAD and NADH redox states in Saccharomyces cerevisiae. Journal of Separation Science 31:3202-3211
  • D. Chen, A. D. Steele, G. Hutter, J. Bruno, A. Govindarajan, E. Easlon, S.-J. Lin, A. Aguzzi, S. Lindquist and L. Guarente (2008) Calorie Restriction and SIRT1 Depletion Delay the Onset of Prion Disease. Experimental Gerontology 43:1086-1093
  • J. Sporty, S. J. Lin, M. Kato, T. Ognibene, B. Stewart, K. Turteltaub, and G. Bench (2009) Quantitation of NAD(+) biosynthesis from the salvage pathway in Saccharomyces cerevisiae. Yeast. (PMID: 19399913)
  • S. P. Lu, M. Kato, and S. J. Lin (2009) Assimilation of Endogenous Nicotinamide Riboside Is Essential for Calorie Restriction-mediated Life Span Extension in Saccharomyces cerevisiae. J Biol Chem 284:17110-9. (PMID: 19416965)
  • C. Wang, C. Skinner, E. Easlon and S. -J. Lin (2009) Deleting the 14-3-3 Protein Bmh1 Extends Life Span in Saccharomyces cerevisiae by Increasing Stress Response. Genetics (In press)
Laboratory Personnel:
323 Briggs

Graduate students: Erin Easlon (BMB), Chen Wang (GGG), Shu-Ping Lu (GGG), Craig Skinner (BMB), Michiko Kato (MGG), Felicia Tsang (BMB)

325 Briggs

Bin Li (postdoctoral fellow)

Courses:
BIS 104 Regulation of cell function Winter,Spring
MCB 220L BMB/CDB rotaion course Fall,Winter
MIC 198 Introduction to Research Spring