Kaz Shiozaki
Professor
kshiozaki@ucdavis.edu

Microbiology

Office
201 Briggs Hall
752-3628

Lab
752-3597


Picture of Kaz Shiozaki
 
Degrees:
1992 PhD Kyoto University Biochemistry/Molecular Biology
1989 MS Kyoto University Biochemistry
1987 BS Kyoto University Biology
Research Interests:

The stress-signaling MAPK cascade is evolutionarily conserved from yeast to humans and implicated in cancer cells' responses to chemotherapies/radio therapies as well as inflammation in asthma and arthritis. My laboratory utilizes fission yeast as a genetically amenable model system to elucidate the regulation and function of the stress MAPK pathway.
Awards:
Human Frontier Science Program, Long-term Research Fellow
American Cancer Society, California Division, Senior Research Fellow
National Academies Education Fellow in Life Science
Department and Center Affiliations:
UC Davis Cancer Center
Professional Societies:
American Society for Cell Biology, American Society for Microbiology, American Association for the Advancement of Science
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology  
Graduate Groups not Housed in CBS:
Microbiology  
Publications: Last updated 11/19/2009
  • Morigasaki S, K Shimada, A Ikner, M Yanagida and K Shiozaki. 2008. Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Molecular Cell, 30: 108-113.
  • Tatebe H, K Nakano, R Maximo and K Shiozaki. 2008. Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Current Biology, 18: 322-330.
  • Ikeda K, S Morigasaki, H Tatebe, F Tamanoi and K Shiozaki. 2008. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle, 7: 358-364.
  • Wang L and K Shiozaki. 2006. The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. FEBS Letter, 580: 2409-2413.
  • Tatebe H, K Shimada, S Uzawa, S Morigasaki and K Shiozaki. 2005. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Current Biology, 15: 1006-1015.
  • Wang L, K Shimada, M Morishita and K Shiozaki. 2005. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase, Spc1/Sty1, and the Hal4 protein kinase. Molecular and Cellular Biology, 25: 3945-3955.
  • Ikner A and K Shiozaki. 2005. Yeast signaling pathways in the oxidative stress response. Mutation Research 569:13-27.
  • Tatebe H and K Shiozaki. 2003. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Molecular and Cellular Biology 23:5132-5142.
  • Nguyen AN, AD Ikner , M Shiozaki, SM Warren, and K Shiozaki. 2002. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Molecular Biology of the Cell. 13:2651-2663
  • Santos JL and K Shiozaki. 2001. Fungal histidine kinases. Science's STKE, 2001(98): RE1.
  • Shiozaki K. 2009. Nutrition-minded cell cycle. Science Signaling, 2: pe74
Laboratory Personnel:
203/207 Briggs

Shin Murayama, David RIchter, Mitsue Shiozaki, Nozomi Tahara, Hisashi Tatebe, Amy Tran, Boram You

Teaching Interests:
Intracellular signal transduction in eukaryotes. Yeast genetics and cell biology.
Courses:
BIS 104 Regulation of Cell Function
MIC 170 Yeast Molecular Genetics