Jodi Nunnari
Professor
jmnunnari@ucdavis.edu

Molecular & Cellular Biology

Office
0214A Briggs Hall
530.754.9774


Picture of Jodi Nunnari
 
Degrees:
1989 PhD Vanderbilt University Pharmacology
1984 BA College of Wooster, Ohio Chemistry
Research Interests:

My laboratory is interested in the mechanisms that govern the organization and transmission of mitochondria and mitochondrial DNA in eukaryotic cells.
Awards:
Chancellor's Fellow
Phi Beta Kappa
Professional Societies:
The American Society for Cell Biology
American Society for Biochemistry and Molecular Biology
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology  
Graduate Groups not Housed in CBS:
Microbiology  
Publications:
  • Cassidy-Stone, A., Chipuk, J.E., Ingerman, E., Song, C., Yoo, C., Kuwana, T., Kurth, M.J., Shaw. J., Hinshaw. J.E., Green, D.R., and Nunnari, J. 2008 Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak dependent mitochondrial outer membrane permeabilization. Developmental Cell, in press.
  • Meeusen S, DeVay R, Block J, Cassidy-Stone A, Wayson S, McCaffery JM, Nunnari J. Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell. 2006 Oct 20;127(2):383-95.
  • Hoppins, S., Lackner, L. and Nunnari, J. 2007 The machines that fuse and divide mitochondria. Annual Review of Biochemistry, 76: 751-80.
  • Naylor K, Ingerman E, Okreglak V, Marino M, Hinshaw JE, Nunnari J. Mdv1 interacts with assembled dnm1 to promote mitochondrial division. J Biol Chem. 2006 Jan 27;281(4):2177-83. Epub 2005 Nov 4.
  • Ingerman E, Nunnari J. A continuous, regenerative coupled GTPase assay for dynamin-related proteins. Methods Enzymol. 2005;404:611-9.
  • Ingerman E, Perkins EM, Marino M, Mears JA, McCaffery JM, Hinshaw JE, Nunnari J. Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol. 2005 Sep 26;170(7):1021-7.
  • Meeusen, S., McCaffrey, J.M., and Nunnari, J. (2004) Mitochondrial fusion intermediates revealed in vitro. Science, in press and published online at Science Express, 5 August 2004 / Page 1/ 10.1126/science.1100612.
  • Osteryoung, K and Nunnari J. (2003) The division of endosymbiotic organelles. Science, 302: 1698-1704.
  • Meeusen, S. and Nunnari, J. (2003) Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome. Journal of Cell Biology, 63: 503-510.
  • Scott, S.V., Cassidy-Stone, A. Meeusen, S.L. and Nunnari, J. (2003) Staying in aerobic shape: How the structural integrity of mitochondria and mtDNA is maintained. Current Opinion in Cell Biology, 15:482-8.
  • Wong, E.D., Wagner J.A., Scott, S.V., Okreglak, V., Holewinske, T.J., Cassidy-Stone, A., and Nunnari, J. (2003) The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. Journal of Cell Biology, 160, 303-311.
  • Tieu, Q., Okreglak, V., Naylor, K., and Nunnari, J. (2002) The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission. Journal of Cell Biology, 158, 445-452.
  • Nunnari, J., Wong, E., Meeusen, S., and Wagner, J. (2002) Methods for studying the behavior of mitochondria. In Guide to Yeast Genetics and Molecular and Cell Biology, Methods in Enzymology, vol. 30, Guthrie and Fink.
  • Nunnari, J. and Shaw J.M. Mitochondrial dynamics and division in budding yeast. (2002) Trends in Cell Biology, 12:178-84.
  • Tieu, Q. and Nunnari, J. . 2000. Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. Journal of Cell Biology. 151:353-365
  • Wong, E.D., Wagner J.A., Gorsich, S., McCaffery, J.M., Shaw, J.M., and Nunnari, J.. 2000. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. Journal of Cell Biology. 151:341-352
  • Meeusen, S., Tieu, Q., Wong, E., Weiss, E., Schieltz, D., Yates, J.R. and Nunnari, J. . (1999) Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA. Journal of Cell Biology 145, 291-304.
Teaching Interests:
Cell Biology, biochemistry, and genetics.
Courses:
MCB 140L Cell Biology Laboratory Course
MCB 221D Cellular Biochemistry Winter