Mitchell H. Singer
Professor
mhsinger@ucdavis.edu

Microbiology

Office
268 Briggs Hall
752-9005


Picture of Mitchell H. Singer
 
Degrees:
1990 PhD University of Wisconsin, Madison Bacteriology
1982 BS University of Illinois Microbiology
Research Interests:

Microbial development, gene regulation, and transcriptional control of gene expression.
Department and Center Affiliations:
Department of Microbiology

Professional Societies:
American Society for Microbiology
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology  
Graduate Groups not Housed in CBS:
Microbiology  
Publications: Last updated 11/13/2009
  • Suen, G., J.S. Jakobsen, B.S. Goldman, M. Singer, A. G. Garza, and R.D. Welch. Bacterial Postgenomics: the Promise and Peril of Systems Biology. 2006 J. Bacteriol. 188:7999-8004
  • Pham, V.D., C.W. Shebelut, I.R. Jose, D.A. Hodgson, D.E. Whitworth and M. Singer. PhoP4 is Required for Proper Sporulation and Development-Specific Phosphatase Activities in Myxococcus xanthus. 2006. Microbiology. 152:1609-20
  • Viswanathan, P., M. Singer, and L. Kroos. Role of ?D in regulating genes and signals during Myxococcus xanthus development. 2006. J. Bacteriol. 188:3246-3256
  • Tzeng, L., T. N. Ellis, and M. Singer. DNA replication during aggregation phase is essential for Myxococcus xanthus fruiting body development. 2006. J. Bactiol. 188:2774-79
  • Diodati, M. E. , F. Ossa, N. B. Caberoy, I. R. Jose, W. Hiraiwa, M.M. Igo, M. Singer*, and A.G. Garza*. Nla18, a key regulatory protein required for normal growth and development in Myxococcus xanthus. 2006. J. Bacteriol 188:1733-43.
  • Tzeng, L., and M. Singer. Myxococcus xanthus myxospores contain two copies of the genome. 2005. Proc. Natl. Acad. Sci., USA. 102(40):14428-14433
  • Pham, V.D., C.W. Shebelut, B. Mukherjee, and M. Singer. RasA is Required for Myxococcus xanthus Development and Social Motility. 2005. J. Bacteriol. 187(19):6845-6848
  • Pham, V.D., C.W. Shebelut, E.J. Zumstein, and M. Singer. BrgE is a regulator of Myxococcus xanthus development. 2005. Mol. Microbiol. 57:762-773
  • Pham, V.D., C.W. Shebelut, M. E. Diodati, C.T. Bull and M. Singer. Mutations Affecting Predation Ability of the Soil Bacterium Myxococcus xanthus. 2005. Microbiol. 151:1865-74
  • Baer, P., A. G. Garza and M. Singer. nsd, a locus that affects the Myxococcus xanthus cellular response to nutrient concentration. Accepted for publication J. Bacteriology
  • Pollack, J.S. and M. Singer. SdeK, a histidine kinase required for Myxococcus xanthus development. 2001. Journal of Bacteriology 183(12):3589-3596
  • Garza, A.G., B.Z. Harris, B.M. Greenberg, and M. Singer. Control of asgE expression during growth and development of Myxococcus xanthus. 2000. Journal of Bacteriology. 182(23):6622-6629
  • Garza, A.G., B.Z. Harris, J.S. Pollack, and M. Singer. The asgE locus is required for cell-cell signaling during Myxococcus xanthus development. 2000. Molecular Microbiology. 35:812-824
  • Karamanos, Y., M. Singer, and L. Sogaard-Anderson. Meeting Review: 25th International Conference on the Biology of the Myxobacteria. 1999. Molecular Microbiology. 31:1863-1869.
  • Harris, B.Z. and M. Singer. 1998. Identification and characterization of the Myxococcus xanthus argE gene.. Journal of Bacteriology. 188(23):6412-6414
  • Garza, A.G., J.S. Pollack, B.Z. Harris, A. Lee, I.M. Keseler, E.F. Licking, and M. Singer. 1998. SdeK is required for early fruiting body development in Myxococcus xanthus. Journal of Bacteriology. 180:4628-4637
  • Harris BZ, D Kaiser, and M Singer. 1998. The guanosine nucleotide (p)ppGpp initiates development and A-factor production in Myxococcus xanthus. Genes and Development. 12:1022-1035
  • F. Ossa, M. E. Diodati, N.B. Caberoy, M. Edmonds, A.G. Garza and M. Singer. 2007. The Myxococcus xanthus Nla4 protein is important for expression of stringent response-associated genes, ppGpp accumulation and fruiting body development. J Bacteriol. 2007 189(23):8474-8483
  • C.J. Rosario and M. Singer. The Myxococcus xanthus Developmental Program Can Be Delayed by Inhibition of DNA Replication J. Bacteriol. 2007 189: 8793-8800.
  • Bode, Helge B., M. W. Ring, G. Schwär, I.R. Jose, M. Singer, and Rolf Müller. Identification of additional players in the alternative biosynthesis pathway to isovaleryl-CoA in the myxobacterium Myxococcus xanthus. 2008. ChemBioChem
  • M.E. Diodati, R. Gill, L. Plamann, and M. Singer. 2008 Development I: Initiation and Early developmental events. Chapter 3 in “Myxobacteria: multicellularity and differentiation”. Ed. D. Whitworth ASM Press, Washington D.C.
Teaching Interests:
Prokaryotic Developmental biology. Bacteriology
Courses:
MIC 155L Prokaryotic Gentics and Physiology Laboratory Spring
MIC 140 Physiololgy of Prokaryotes Fall