Stephen Kowalczykowski
Distinguished Professor
sckowalczykowski@ucdavis.edu

Microbiology
Molecular & Cellular Biology

Office
Briggs Hall 310
530-752-5938

Lab
Briggs 303, 304, 306, 307, 315
530-754-9704, 9703, 9702, 9705,
752-6849

Lab
Life Science 3243
530-754-9051


Picture of Stephen C. Kowalczykowski
 
Degrees:
1976 PhD Georgetown University Chemistry (Biochemistry)
1972 BS Rensselaer Polytechnic Institute Chemistry
Research Interests:

Biochemical mechanism of genetic recombination and DNA repair; DNA helicases and motor proteins; Physical and structural aspects of protein-nucleic acid interactions; Single-molecule biophysics; Nanotechnology; Cancer biology.
http://www-mic.ucdavis.edu/sklab/kowalczykowskilab.htm

Awards:
Phi Lambda Upsilon, Chemical Honor Society, 1971
Sigma Xi, 1974
American Cancer Society Postdoctoral Fellowship, 1977-1980
American Cancer Society Junior Faculty Research Award, 1983-1986
National Institutes of Health MERIT Award, 2000-2010
American Association for the Advancement of Science, Fellow, 2001
American Academy of Microbiology, Fellow, 2003
University of California, Davis, Academic Senate Faculty Research Lecture Award, 2005
American Academy of Arts & Sciences, Fellow, 2005
National Academy of Sciences, Member, 2007
Department and Center Affiliations:
Department of Microbiology
Department of Molecular and Cellular Biology
Professional Societies:
American Society for Biochemistry and Molecular Biology, FASEB
American Chemical Society, Division of Biological Chemistry
American Society for Microbiology
American Association for the Advancement of Sciences
Biophysical Society
CBS Graduate Group Affiliations:
Biophysics  
Genetics  
Biochemistry, Molecular, Cellular and Developmental Biology  
Graduate Groups not Housed in CBS:
Microbiology  
Publications: Last updated 10/5/2009
  • Handa, N., Morimatsu, K., Lovett, S.T., and Kowalczykowski, S.C. (2009). Reconstitution of initial steps of double-strand DNA break repair by the RecF pathway of E. coli. Genes & Dev., 23, 1234-1245.
  • Carreira, A., Hilario, J., Amitani, I., Baskin, R.J., Shivji, M.K.K., Venkitaraman, A.R., and Kowalczykowski, S.C. (2009). The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51. Cell, 136, 1032-1043
  • Haseltine, C. A. and Kowalczykowski, S.C. (2009). An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA. Nucl. Acids Res., 37, 2757-2770
  • Nimonkar, A.V., Sica, A., and Kowalczykowski, S.C. (2009). Rad52 promotes second-end DNA capture in double-strand break repair to form complement-stabilized joint molecules. Proc. Natl. Acad. Sci. U.S.A., 106, 3077-3082
  • Hilario, J., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2009). Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules. Proc. Natl. Acad. Sci. U.S.A., 106, 361-368
  • Dillingham, M.S. and Kowalczykowski, S.C. (2008). RecBCD enzyme and the repair of double-stranded DNA breaks. Microbiol. Mol. Biol. Rev., 72, 642–671
  • Nimonkar, A.V., Ozsoy, A.Z., Genschel, J., Modrich, P., and Kowalczykowski, S.C. (2008). Human Exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. Proc. Natl. Acad. Sci. U.S.A., 105, 16906-16911
  • Kowalczykowski, S.C. (2008). Structural biology: Snapshots of DNA repair. Nature, 453, 463-466
  • Spies, M., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2007). RecBCD enzyme switches lead motor subunits in response to Chi-recognition. Cell, 131, 16, 694-705
  • Galletto, R., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2006). Direct observation of individual RecA filaments assembling on single DNA molecules. Nature, 443, 875-878
Laboratory Personnel:
Briggs Hall 306
http://www.mic.ucdavis.edu/sklab/people.htm
Ryan Jensen, Behzad Rad, Theetha Pavankumar, Aura Carriera

Briggs Hall 304
http://www.mic.ucdavis.edu/sklab/people.htm
Jason Bell, Hsu-Yang Lee, Liang Yang, Galina Drofyak, Valentin Taryanik

Briggs Hall 303
http://www.mic.ucdavis.edu/sklab/people.htm
Chris Dombrowski, Bian Liu, Ichiro Amitani

Briggs Hall 307
http://www.mic.ucdavis.edu/sklab/people.htm
Tony Forget, Taeho Kim, Lisa Vancelette, Katsumi Morimatsu, Amitabh Nimonkar

Briggs Hall 315
http://www.mic.ucdavis.edu/sklab/people.htm
Jode Planck, Petr Cejka, Elda Cannavo

Teaching Interests:
Bacterial physiology and genetics. Molecular biology and biochemistry. Biophysics. Principles of protein-nucleic acid interactions. Advanced concepts in DNA metabolism. DNA repair and recombination. http://
Courses:
MIC 276 Adv Concepts DNA Metab Spring
MIC 263 Principles of Protein-Nucleic Acid Interactions Winter