Aldrin V Gomes
Assistant Professor
avgomes (at) ucdavis (dot) edu

Neurobiology, Physiology and Behavior

Office
177 Briggs Hall
(530) 754-9548


Picture of Aldrin Gomes
 
Degrees:
1998 PhD University of the West Indies, St. Augustine, Trinidad and Tobago (Biochemistry)
1991 BS University of the West Indies, St. Augustine, Trinidad and Tobago
Awards:
Alpha Omega Merit Award from the University of the West Indies School of Medicine, 1995
American Heart Association Travel Award, 2004
American Society Biochemistry and Molecular Biology Travel Fellowship, 2000
Biochemical Society Fellowship, 2000
Scientist Development Grant from the Muscular Dystrophy Association, 2002
Scientist Developmental Grant from the American Heart Association, 2008
Young Scientist Award from the International Union of Biochemistry and Molecular Biology, 1997
Department and Center Affiliations:
Neurobiology, Physiology and Behavior (NPB), College of Biological Sciences
Physiology and Membrane Biology, School of Medicine
Professional Societies:
American Heart Association (AHA)
American Physiological Society
Biophysical Society
Cardiac Society
Internation Society for Heart Research
CBS Graduate Group Affiliations:
Molecular, Cellular, and Integrative Physiology  
Publications:
  • Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. (2009) Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 8:302-15.
  • Mayr M., Grainger, D., Mayr, U., Leroyer, A.S., Leseche, G., Sidibe, A., Herbin, O., Yin, X., Gomes, A.V., Madhu, B., Griffiths, J.R., Xu, Q., Tedgui, A. and Boulanger, C.M. (2009) Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ. Cardiovasc. Genet. in press.
  • Protein Degradation
  • Mayr, M., Liem, D., Zhang, J., Li, X., Avliyakulov, N.K., Yang, J.I., Young, G., Vondriska, T.M., Ladroue, C., Madhu, B., Griffiths, J.R., Gomes, A., Xu, Q., Ping, P. (2009) Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J. Mol. Cell. Cardiol. 46:268-77.
  • Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. (2007) Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 6:2021-2031.
  • Gomes, A.V. Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. (2006) Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.
  • Zong, C., Gomes, A.V. Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. (2006) Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.
  • Gomes, A.V. Zong, C., Ping, P. (2006) Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxidants & Redox Signaling 9/10:1677-1691.
  • Gomes, A.V. et al., (2005) Murine Cardiac 26S Proteasome: An Organelle Awaiting Exploration. Ann N Y Acad Sci. 1047, 197-207.
  • Barnes, J.A,, Singh, S., Gomes, A.V. (2005) Protease activated receptors in cardiovascular function and disease. Mol. Cell Biochem. 263, 227-39.
  • Barnes, J.A,, Gomes, A.V. (2002) Proteolytic signals in the primary structure of annexins. Mol. Cell Biochem. 231, 1-7.
  • Cuervo A.M., Gomes A.V., Barnes J.A., Dice J.F. (2000) Selective Degradation of Annexins by Chaperone-mediated Autophagy. J. Biol. Chem. 275, 33329-33335.
  • Role of Troponins in Muscle Contraction and Disease
  • Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. (2008) Cardiac troponin T forms a tetramer in vitro. Biochemistry. 47, 1970-6.
  • Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. (2008) Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 283:20484-94
  • Gomes, A.V., Liang, J., Potter J.D. (2005). Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 280, 30909-15.
  • Gomes, A.V., Harada, K., Potter J.D. (2005). A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Calcium-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 39, 754-65.
  • Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. (2005) Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 280, 17584-92.
  • Gomes, A.V., Venkatraman, G., Potter, J.D. (2005) The miscommunicative cardiac cell: when good proteins go bad. Ann N Y Acad Sci. 1047, 30-7.
  • Gomes, A.V., Venkatraman, G., Davis, J.P., Tikunova, S.B., Engel, P., Solaro, R.J., Potter J.D. (2004) Cardiac troponin T isoforms affect the Calcium sensitivity of force development in the presence of slow skeletal troponin I: Insights into the role of troponin T isoforms in the fetal heart. J. Biol Chem. 279, 49579-87.
  • Venkatraman, G., Harada K., Gomes, A.V., Kerrick, W.G., Potter, J.D. (2003) Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J. Biol Chem. 278, 41670-6.
  • Gomes, A.V., Guzman, G., Zhao, J., Potter, J.D. (2002) Cardiac troponin T isoforms affect the Calcium-sensitivity and inhibition of force development: insights into the role of troponin T isoforms in the heart. J. Biol Chem. 277, 35341-35349.
  • Lang, R., Gomes, A.V., Zhao, J., Housmans, P.R., Miller, T., Potter, J.D. (2002) Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J. Biol. Chem. 277, 11670-11678.
  • Miller, T., Szczesna, D., Housmans, P.R., Zhao, J., de Freitas, F., Gomes, A.V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W.G. and Potter, J.D. (2001) Abnormal Contractile Function in Transgenic Mice Expressing an FHC-Linked Troponin T (I79N) Mutation. J. Biol. Chem. 276, 3743-3755.
  • Szczesna, D., Ghosh, D., Li, Q., Gomes, A.V., Guzman, G., Arana, C., Zhi, G., Stull, J.T., Potter, J.D.(2001) Abnormal Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Calcium binding and phosphorylation. J. Biol. Chem. 276, 7086-7092.
  • Related Publications
  • Baldán A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. (2008) J Immunol. 180,3560-8.
  • Yuan, T., Gomes, A.V., Barnes, J.A., Hunter, H.N. and Vogel, H.J. (2004) Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I. Arch. Biochem. Biophys. 421, 192-206.
  • Gutierrez-Ford, C., Levay, K., Gomes, A.V., Perera, E.M., Som, T., Kim, Y.M., Benovic J.L., Berkovitz G.D., Slepak V.Z. (2003) Characterization of Tescalcin, a Novel EF-Hand Protein with a Single Calcium-Binding Site: Metal-Binding Properties, Localization in Tissues and Cells, and Effect on Calcineurin. Biochemistry 42, 14553-14565.
  • Gomes A.V., Barnes J.A., Vogel H.J. (2000) Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin. Arch Biochem Biophys. 379, 28-36.
Laboratory Personnel:
Muscle Physiology and Proteomics Laboratory/176 Briggs Hall
http://www.npb.ucdavis.edu/labs/gomes/index_files/Page649.htm
Qian Xu, MD, PhD Susan Nguyen, BSc Rylie Siu, BSc

Courses:
EXB 110 Exercise Metabolism Spring