Christopher S. Fraser
Assistant Professor
csfraser@ucdavis.edu

Molecular & Cellular Biology

Office



Picture of Christopher Fraser
 
Degrees:
1999 PhD University of Sussex Biochemistry
1995 BS University of Sussex Biology
Awards:
Wellcome Trust Prize Studentship 1995-1998
Department and Center Affiliations:
Molecular and Cellular Biology
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology  
Publications:
  • Fraser, C. S., Hershey, J. W., and Doudna, J. A. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat. Struct. Mol. Biol. 2009 Apr;16(4):397-404.
  • Zhou, M., Sandercock, A. M., Fraser, C. S., Ridlova, G., Stephens, E, Schenauer, M. R., Yokoi-Fong, T., Barsky, D., Leary, J. A., Hershey, J. W., Doudna, J. A., and Robinson, C. V. Mass Spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc. Natl. Acad. Sci. U S A. 2008 Nov 25;105(47):18139-44.
  • Poyry, T. A. A., Kaminski, A., Connell, E., Fraser, C. S., and Jackson, R. J. The mechanism of an exceptional case of reinitiation after translation of a long open-reading frame reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev. 2007 Dec 1;21(23):3149-62.
  • Fraser, C. S., Berry, K. E., Hershey, J. W., and Doudna, J. A. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol. Cell. 2007 Jun 22;26(6):811-9.
  • Fraser, C. S., and Doudna, J. A. Quantitative studies of ribosome conformational dynamics. Q. Rev. Biophys. 2007 May;40(2):163-89.
  • Damoc, E., Fraser, C. S., Zhou, M., Videler, H., Mayeur, G. L., Hershey, J. W., Doudna, J. A., Robinson, C. V., and Leary, J. A. Structural Characterization of the Human Eukaryotic Initiation Factor 3 Protein Complex by Mass Spectrometry. Mol. Cell Proteomics. 2007 Jul;6(7):1135-1146.
  • Fraser, C. S., and Doudna, J. A. Structural and mechanistic insights into Hepatitis C viral translation initiation. Nat. Rev. Microbiol. 2007 Jan;5(1):29-38.
  • Siridechadilok, B., Fraser, C. S., Hall, R. J., Doudna, J. A., and Nogales, E. Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis. Science. 2005 Dec 2;310(5753):1513-5.
  • Fraser, C. S., and Hershey, J. W. B. Movement in Ribosome Translocation. J. Biol. 2005, 4:8
  • Ji, H., Fraser, C. S., Yu, Y., Leary, J., and Doudna, J. A. Coordinated assembly of human translation initiation complexes by the Hepatitis C Virus internal ribosome entry site RNA. Proc. Natl. Acad. Sci. U. S. A. 2004 Dec 7;101(49):16990-5.
  • Fraser, C. S., Lee, J. Y., Mayeur, G. L., Bushell, M., Doudna, J. A., and Hershey, J. W. B. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40S ribosomal subunits in vitro. J. Biol. Chem. 2004 Mar 5;279(10):8946-56.
  • Mayeur, G. L., Fraser, C. S., Pieretti, F., Block, K. L., and Hershey, J. W. B. Characterization of eIF3k, a newly discovered subunit of mammalian translation initiation factor eIF3. Eur. J. Biochem. 2003 Oct 15; 270(20): 4133-4139.
  • Daughenbaugh, K. F., Fraser, C. S., Hershey, J. W. B., and Hardy, M. E. The genome-linked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment. EMBO J. 2003 Jun 2;22(11):2852-9.
  • Fraser, C. S., Pain, V. M., and Morley, S. J. Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein. Biochem. J. 1999 Sep 15; 342 Pt 3:519-26.
  • Fraser, C. S., Pain, V. M., and Morley, S. J. The association of initiation factor 4F with poly(A)-binding protein is enhanced in serum-stimulated Xenopus kidney cells. J. Biol. Chem. 1999 Jan 1; 274(1):196-204.
Laboratory Personnel:
327 Briggs Hall

Shareghe Mehraeen, Postdoc; Nancy Villa, BMB Graduate Student; Ali Ozes, Junior Specialist; Angelie Do; Junior Specialist; Gao Chong, Undergraduate.