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Su-Ju Lin

Associate Professor

Microbiology and Molecular Genetics

(530) 754-6081

(530) 754-6082


2003 Postdoctoral Fellow-Massachusetts Institute of Technology Biology
1997 PhD Johns Hopkins University Toxicological Sciences
1991 BA National Taiwan University Environmental Health Sciences

Research Interests:

Regulation of NAD+ metabolism

Molecular mechanisms of Calorie Restriction and Aging


1997-1998 Anna Fuller Fund for Cancer Research Fellowship
1999-2002 Individual National Research Service Award
2004-2008 Ellison Medical Foundation New Scholar in Aging

Department and Center Affiliations:

UC Davis Cancer Center

Professional Societies:

Genetic Society of America
The American Society for Biochemistry

CBS Graduate Group Affiliations:

Biochemistry, Molecular, Cellular and Developmental Biology  

Specialties / Focus:

Biochemistry, Molecular, Cellular and Developmental Biology
Metabolism and Molecular Physiology
Signal Transduction and Gene Regulation


Graduate Groups not Housed in CBS:



Last updated 10/22/2012
S. -J. Lin, P. Defossez and L. Guarente. (2000) Life span extension by calorie restriction in S. cerevisiae requires SIR2 and NAD. Science 289:2126-8.

S. -J. Lin, M. Kaeberlein, A. A. Andalis, L. A. Sturtz, P.-A. Defossez, V. C. Culotta, G. R. Fink and L. Guarente (2002) Calorie restriction extends life span by shifting carbon toward respiration. Nature 418:344-348.

S. -J. Lin and L. Guarente (2003) NAD, a metabolic regulator of transcription, longevity and diseases. Current Opinion in Cell Biology 15:241-246.

S. -J. Lin, E. Ford, M. Haigis, G. Liszt and L. Guarente (2004) Calorie restriction extends life span by lowering the NADH levels. Genes and Development 18:12-16.

D. Lamming, M. Latorre, O. Medvedik, S. N. Wong, F. A. Tsang, C. Wang, S.-J. Lin* and D. A. Sinclair* (2005) HST2 mediates SIR2-independent lifespan extension by calorie restriction. Science 309:1861-64

L. Bordone, M. C. Motta, F. Picard, A. Robinson, U. S. Jhala, J. Apfeld, T. McDonagh, M. Lemieux, M. McBurney, E. J. Easlon, S.-J. Lin, and L. Guarente (2005) Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ?-cells. PLoS Biol 4(2):e31.

S. -J. Lin (2006) Molecular Mechanisms of Longevity regulation and calorie restriction. In Nutritional Genomics (Editors: J. Kaput and R. L Rodriguez), pp207-219. John Wiley and Sons, Inc., Hoboken, New Jersey.

S. -J. Lin and L. Guarente (2006) Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2, e33

D. A. Sinclair, S. -J. Lin and L. Guarente (2006) Life-span extension in yeast. Science 312, 195-197.

E. Easlon, F. Tsang, I. Dilova, C. Wang, S-P Lu, C. Skinner and S-J Lin. (2007) The Dihydrolipoamide Acetyltransferase Is A Novel Metabolic Longevity Factor And Is Required For Calorie Restriction Mediated Life Span Extension. J. Biol.Chem. 282:6161-71

I. Dilova, E. Easlon and S.-J. Lin (2007) Calorie Restriction and the Nutrient Sensing Signaling Pathways. Cell Mol Life Sci, 64:752-767.

S. -J. Lin and D. Sinclair (2008) Molecular mechanism of aging - insights from yeast. In The Molecular Biology of Aging (Editors: L. Guarente, L. Partridge, and D.Wallace), pp483-516. Cold Spring Harbor Laboratory Press

E. Easlon, F. Tsang, C. Skinner, C. Wang and S-J Lin (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction mediated life span extension in yeast. Genes and Development 22:931-944

D. Chen, J. Bruno, E. Easlon, S.-J. Lin, F. Alt and L. Guarente (2008) Tissue-specific Regulation of SIRT1 by Calorie Restriction. Genes and Development 22:1753-7

J. L. Sporty, Md. M. Kabir, K. W. Turteltaub, T. Ognibene, S.-J. Lin, and G. Bench. (2008) Single sample extraction protocol for quantification of NAD and NADH redox states in Saccharomyces cerevisiae. Journal of Separation Science 31:3202-3211

D. Chen, A. D. Steele, G. Hutter, J. Bruno, A. Govindarajan, E. Easlon, S.-J. Lin, A. Aguzzi, S. Lindquist and L. Guarente (2008) Calorie Restriction and SIRT1 Depletion Delay the Onset of Prion Disease. Experimental Gerontology 43:1086-1093

J. Sporty, S. J. Lin, M. Kato, T. Ognibene, B. Stewart, K. Turteltaub, and G. Bench (2009) Quantitation of NAD(+) biosynthesis from the salvage pathway in Saccharomyces cerevisiae. Yeast. (PMID: 19399913)

S. P. Lu, M. Kato, and S. J. Lin (2009) Assimilation of Endogenous Nicotinamide Riboside Is Essential for Calorie Restriction-mediated Life Span Extension in Saccharomyces cerevisiae. J Biol Chem 284:17110-9. (PMID: 19416965)

C. Wang, C. Skinner, E. Easlon and S. -J. Lin (2009) Deleting the 14-3-3 Protein Bmh1 Extends Life Span in Saccharomyces cerevisiae by Increasing Stress Response. Genetics 183:1373-84. (PMID:19805817)

S.-P. Lu and S.-J. Lin (2010) Regulation of Yeast Sirtuins by NAD+ Metabolism and Calorie Restriction. Biochim Biophys Acta 1804:1567-1575 (PMC2886167)

C. Skinner and S. J. Lin (2010) Effects of calorie restriction on life span of microorganisms. Appl Microbiol Biotechnol. 88: 817-28. (PMC2944023)

B. Li, C. Skinner, P. Castello, M. Kato, E. Easlon, L. Xie, T. Li, S. P. Lu, C. Wang, F. Tsang, R. Poyton and S.-J. Lin (2011) Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels. Journal of Aging Research 2011:673185. (PMC3092605)

Lu S. P. and S. -J. Lin (2011) Phosphate responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae. J. Biol Chem. 286:14271-81. (PMC3077628).

C. Skinner and S. -J. Lin (2012) Calorie Restriction, Mitochondria and Longevity in Saccharomyces cerevisiae. In Mitochondrial Signaling in Health and Disease (Oxidative Stress and Disease), pp301-320 (Editors: Sten Orrenius, Lester Packer and Enrique Cadenas)

Laboratory Personnel:

323 Briggs

Graduate students: Michiko Kato (MGG), Felicia Tsang (BMCDB)


BIS 104 Regulation of cell function Winter,Spring
MIC 91/191 Introduction to Research Spring
MIC 170 Yeast Molecular Genetics spring