Lesilee S. Rose
Professor
lsrose@ucdavis.edu
Molecular & Cellular Biology
Office
3224 Life Sciences Addition
754-9884/754-9891
Degrees:
1991
PhD
Princeton University
Molecular Biology
1986
BS
College of William and Mary
Biology
Research Interests:
Developmental and cell biology of C. elegans, with an emphasis on the control of cell division patterns and polarity.
Awards:
Basil O'Connor Starter Scholar Research Award
Department and Center Affiliations:
Department of Molecular and Cellular Biology
Professional Societies:
Society for Developmental Biology
Genetics Society of America
American Society for Cell Biology
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology
Genetics
Specialties / Focus:
Biochemistry, Molecular, Cellular and Developmental Biology
Cell Division and the Cytoskeleton
Development
Organelle and Cytoskeleton Dynamics
Genetics
Publications:
Last updated 8/6/2012
Eugenel B. Espiritu, Lori E. Krueger, Anna Ye and Lesilee S. Rose, 2012. CLASPs function redundantly to regulate microtubule length in the C. elegans embryo. Dev Biol. 368, 242-54.
Krueger Lori E, Wu Jui-ching, Tsou Meng-Fu Bryan, Rose Lesilee S 2010. LET-99 inhibits lateral posterior pulling forces during asymmetric spindle elongation in C. elegans embryos.J Cell Biol 189(3):481-95
Wei Li, Leah DeBella, Tugba Guven-Ozkan, Rueyling Lin and Lesilee Rose. 2009. An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. J Cell Bio 187, 33-42
Park, Dae Hwi and Lesilee S. Rose. Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning. Dev Biol 315, 42-54
Wu, Jui-Ching, and Lesilee S. Rose. 2007. PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in C. elegans embryos. 2007. Mol Biol Cell. 18:4470-82
DeBella, Leah R., Adam Hayashi, and Lesilee S. Rose. 2006. LET-711, the C. elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos. Mol. Biol. Cell 17:4911-4924
Gonczy, Pierre, and Lesilee S. Rose. 2005. Asymmetric cell division and axis formation in the embryo. In WormBook, ed.The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.7.1, http://www.wormbook.org.
Meng-Fu Bryan Tsou, Wei Ku, Adam Hayashi, and Lesilee S. Rose. 2003. PAR-dependent and geometry-dependent mechanisms of spindle positioning. J Cell Bio1: 160(6):845-55.
Meng-Fu Bryan Tsou, Adam Hayashi, and Lesilee S. Rose. 2003. LET-99 opposes Ga/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling. Development 130: 5717-30.
Tsou M-F, A Hayashi, LR. DeBella, G McGrath, and LS Rose. 2002. LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development. 129(19):4469-4481
Basham, SE and LS Rose. 2001. The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily. Development. 128(22):4645-4656
Teaching Interests:
Developmental biology. Genetics.