Sue C. Bodine
Professor
scbodine (at) ucdavis (dot) edu

Neurobiology, Physiology and Behavior

Office
187 Briggs
(530) 752-0694

Lab
(530) 752-5048


Picture of Sue Bodine, Ph.D
 
Degrees:
1985 PhD University of California, Los Angeles (Physiological Science)
1981 BS University of California, Los Angeles
Research Interests:

Molecular and cellular mechanisms that regulate skeletal muscle growth and the maintenance of skeletal muscle mass and function. Integration of in vivo biology/pharmacology, mouse genetics, cell biology/biochemistry and molecular biology techniques to identify signaling pathways responsible for muscle atrophy that occurs during inactivity, various diseases processes and aging. Neuomuscular physiology and neurodegenerative diseases. Integrative physiology: interrelationships between muscle and other systems such as adipose tissue in the regulation of metabolism, glucose regulation and various diseases.
Neuromuscular physiology, integrative muscle biology, regulation of muscle size, mechanisms responsible for muscle atrophy following disuse, disease, and aging.
Department and Center Affiliations:
Neurobiology, Physiology & Behavior (CBS), Physiology and Membrane Biology (SOM)
Professional Societies:
American Physiological Society, American Society for Cell Biology, Endocrine Society, American College of Sports Medicine
CBS Graduate Group Affiliations:
Exercise Science  
Molecular, Cellular, and Integrative Physiology  
Publications: Last updated 10/7/2009
  • Hwee DT, Bodine SC. (2009) Age-related deficit in load-induced skeletal muscle growth. J Gerontol A Biol Sci Med Sci. 64(6):618-28.
  • Waddell DS, Baehr LM, van den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC. (2008) The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am J Physiol Endocrinol Metab.295(4):E785-97.
  • Kline, W.O., Panaro, F.J., Yang, H., and Bodine, S.C. (2007) Rapamycin inhibits the growth and muscle sparing effects of clenbuterol. J. Appl. Physiol. 102: 740-741.
  • Baar, K., Nader, G. and Bodine, S.C. (2006) Resistance exercise, muscle loading/unloading and the control of muscle mass. Essays in Biochemistry. 38:1950-1957.
  • Bodine, S.C. (2006) mTOR signaling and molecular adaptations to resistance exercise. Med Sci Sports Exerc. 38:1950-1957.
  • Reynolds, T.H., Bodine, S.C., and Lawrence, J.C. (2002) Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin, amino acids, and skeletal muscle loading. J. Biol. Chem. 277: 17657-17662.
  • Isfort, R.J., Wang, F., Greis, K.D., Sun, Y., Keogh, T.W., Farrar, R.P., Bodine, S.C., and Anderson, N.L. (2002) Proteomic analysis of rat soleus muscle undergoing hindlimb suspension-induced atrophy and reweighting hypertrophy. Proteomics 2: 543-550.
  • Bodine, S.C., Latres, E., Baumhueter, S., Lai, V.K.-L., Nunez, L., Clarke, B., Poueymirou, W., Panaro, F., Na, E., Dharmarajan, K., Pan, Z-Q., Valenzuela, D.M., .DeChiara, T.M., Stitt, T.N., Yancopoulos, G.D., and Glass, D.J. (2001) Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294:1704-1708.
  • Bodine, S.C., Stitt, T.N., Gonzalez, M., Kline, W.O., Stover, G.L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J.C., Glass, D.J., and, Yancopoulos, G.D. (2001) The AKT/mTOR pathway is a critical regulator of skeletal muscle hypertrophy, and can prevent muscle atrophy in vivo. Nature Cell Biology 3: 1014-1019.
  • Rommel, C., Bodine, S.C., Clarke, B.A., Rossman, R., Nunez, L., Stitt, T.N., Yancopoulos, G.D., and Glass, D.J. (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI3K/AKT/mTOR and PI3K/AKT/GSK3 pathways. Nature Cell Biology 3: 1009-1013.
Courses:
EXB 101 Exercise Physiology Fall
EXB 110 Exercise Metabolism Winter
MCB 210A Cellular Physiology Fall