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J. David Furlow

Professor
jdfurlow (at) ucdavis (dot) edu


Neurobiology, Physiology and Behavior

Office
274B Briggs Hall
(530) 754-8609



Degrees:

1992 PhD University of Wisconsin, Madison (Biochemistry)
1985 BS Pennsylvania State University (Biochemistry)
Postdoctoral Fellow - Carnegie Institution of Washington, Department of Embryology

Research Interests:


Molecular basis of hormone action, particularly during development. Analysis of gene expression cascades during morphogenesis. Mechanisms of skeletal muscle atrophy and death.


Department and Center Affiliations:

UCD Cancer Center

Faculty, Physiology course, Marine Biological Laboratory, Woods Hole, MA

Professional Societies:

The Endocrine Society
Society for Developmental Biology
American Physiological Society

CBS Graduate Group Affiliations:

Biochemistry, Molecular, Cellular and Developmental Biology  
Molecular, Cellular, and Integrative Physiology  

Specialties / Focus:

Biochemistry, Molecular, Cellular and Developmental Biology
Cellular Responses to Toxins and Stress
Genomics, Proteomics and Metabolomics
Signal Transduction and Gene Regulation

Publications:

Last updated 12/8/2013
Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. (2012) Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. Jul;26(7):2986-99.
 

Murk AJ, Rijntjes E, Blaauboer BJ, Clewell R, Crofton KM, Dingemans MM, Furlow JD, Kavlock R, Köhrle J, Opitz R, Traas T, Visser TJ, Xia M, and AC Gutleb (2013) Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. Toxicology In Vitro. 27(4):1320-1346
 

Furlow JD, Watson ML, Waddell DS, Neff ES, Baehr LM, Ross AP, and SC Bodine. (2013) Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy. Physiological Genomics 45(23):1168-1185.
 

Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD. (2012) A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure. Am J Physiol Endocrinol Metab. May 1;302(10):E1210-20.
 

Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. (2012) A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. Apr 15;185(8):825-34.
 

Baehr LM, Furlow JD, Bodine SC. (2011) Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids. J Physiol. Oct 1;589(Pt 19):4759-76.
 

Freitas J, Cano P, Craig-Veit C, Goodson ML, Furlow JD, Murk AJ. (2011) Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay. Toxicol In Vitro. Feb;25(1):257-66.
 

Denver, RJ, Scanlan TS, and JD Furlow (2009) Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Developmental Biology (in press).
 

Johnsen SA, Güngör C, Prenzel T, Riethdorf, S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, and I Bach. (2009) Identification of the LIM cofactors CLIM and RLIM as Novel Regulators of Estrogen-Dependent Transcription in Breast Cancer. Cancer Research. 69:128-136
 

Waddell DS, Baehr LM, van der Brandt J, Johnsen SA, Reichardt HM, Furlow JD, and SC Bodine (2008) The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy related MuRF1gene. American Journal of Physiology: Endocrinology and Metabolism. 295:E785-797
 

Schriks M, Roessig JM, Murk AJ, Furlow JD (2007) Thyroid hormone receptor isoform selectivity of thyroid hormone disrupting compounds quantified with an in vitro reporter gene assay. Environmental Toxicology and Pharmacology 23:320-307.
 

Weidner WJ, Waddell DS, Furlow JD. (2006) Measurement of the filtration coefficient (Kfc) in the lung of Gallus domesticus and the effects of increased microvascular permeability. J Comp Physiol [B] 176(6):567-574
 

Furlow, J.D. and E.S. Neff (2006) A developmental switch induced by thyroid hormone: Xenopus laevis metamorphosis. Trends in Endocrinolology and Metabolism 17:40-47.
 

Schriks M, Zvinavashe E, Furlow JD, Murk AJ. (2006) Disruption of thyroid hormone-mediated Xenopus laevis tadpole tail tip regression by hexabromocyclododecane (HBCD) and 2,2',3,3',4,4',5,5',6-nonabrominated diphenyl ether (BDE206). Chemosphere. 65:1904-1908.
 

Lim, W., Neff, E. S., and J. D. Furlow (2004) The mouse muscle creatine kinase promoter faithfully drives reporter gene expression in transgenic Xenopus laevis. Physiological Genomics. 18:79-86
 

Furlow J. D., Yang, H. Y., Hsu, Y. M., Lim, W., Ermio, D. J., Chiellini, G., and T. S. Scanlan (2004) The thyroid hormone receptor agonist GC-1 preferentially induces tissue resorption in Xenopus laevis tadpoles. Journal of Biological Chemistry. 279:26555-26562
 

Luria, A. and J. D. Furlow (2004) Spatiotemporal activation of retinoid-X receptors detected in live vertebrate embryos. Proceedings of the National Academy of Sciences. 101:8987-8992
 

Lim, W, Nguyen, NH, Yang, HY, Scanlan, TS, and JD Furlow (2002) A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. Journal of Biological Chemistry 277:35664-35670
 

Lim, W, and JD Furlow (2002) Ribozyme suppression of endogenous thyroid hormone receptor activity in Xenopus laevis cells. Nucleic Acids Research 30:3490-3496
 

Furlow, JD and A Kanamori (2002) The Transcription Factor Basic Transcription Element-Binding Protein 1 is a Direct Thyroid Hormone Response Gene in the Frog Xenopus laevis. Endocrinology. 143:3295-3305
 


Laboratory Personnel:

Furlow Lab, 274 Briggs Hall

Lucy Dobrawa, Brenda Mengeling



Teaching Interests:

Endocrinology, developmental biology, molecular biology.

Courses:

NPB 101 Systemic Physiology Winter
NPB 128 Comparative Physiology: Endocrinology Winter
NPB 152 Hormones and Behavior Spring