Diana G. Myles
Professor
dgmyles@ucdavis.edu
Molecular & Cellular Biology
Office
3167 Life Sciences Addition
1973
PhD
University of California, Berkeley
Botany
1968
BA
University of California, Berkeley
Botany
The role of the ADAM family, integrins and other proteins in sperm-egg mammalian membrane adhesion and membrane fusion. Sperm membrane polarity and protein-protein interactions during spermatogenesis. A variety of approaches are used including mouse genetics (knockouts and transgenics), molecular biology and protein biochemistry.
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Cho, C., Bunch, D.O., Faure, J.-E., Goulding, E.H., Eddy, E.M., Primakoff, P. and Myles, D.G.. 1998. Fertilization defects in sperm from mice lacking fertilin . Science. 281 :1857-59.
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Primakoff, P and D.G. Myles. 2000. The ADAM gene family: Surface proteins with adhesion and protease activity. Trends Genet.. 16:83-87
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Miller, B., Georges-Labouesse, E., Primakoff, P. and Myles, D.G.. 2000. Normal fertilization occurs in eggs lacking the integrin 6 1 and is CD9-dependent.. J. Cell Biol. . 149: 1289-1295.
Cell biology, developmental biology, and fertilization.