David Krause Wilson
Professor
dave@alanine.ucdavis.edu
Molecular & Cellular Biology
Office
3 Briggs Hall
(530)752-1136
Lab
(530)752-1135
Degrees:
1996
PhD
Baylor College of Medicine
Biochemistry
1991
BA
Rice University
Biochemistry
Research Interests:
Structural biology of enzymes and protein-protein interactions. Projects include 1) protein engineering of enzymes involved in a xylose assimilation (XXX) pathway 2) structure- and combinatorial-based drug design targetting apicomplexan parasitic infection and 3) characterizing the structure and function of WD-repeat domains in protein-protein interaction. Our primary research tool is x-ray crystallography but we usually complement this with biochemical and genetic experiments.
Department and Center Affiliations:
Department of Molecular and Cellular Biology
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology
Biophysics
Specialties / Focus:
Biochemistry, Molecular, Cellular and Developmental Biology
Metabolism and Molecular Physiology
Structural and Mechanistic Biochemistry
Publications:
Last updated 5/21/2010
Cerna D, Wilson DK. (2005) The structure of Sif2p, a WD protein functioning in the SET3 corepressor complex. J. Mol. Biol. 351:923-935.
Wilson DK, Cerna D, Chew E. (2005) The 1.1 Ã… structure of the spindle checkpoint protein Bub3p reveals functional regions. J. Biol. Chem. 280:13944-13951.
Dixon S, Robins L, Elling RA, Liu R, Lam KS, Wilson DK, Kurth MJ. (2005) Discovery of selective aldo-keto reductase ligands: an on-bead assay strategy. Bioorg. Med. Chem. Letts. 15:2938-2942.
Madrona AY, Wilson DK (2004) The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure. Prot. Sci. 13:1557-65.
Ehrensberger AH, Wilson DK (2004) Structural and catalytic diversity in the two family 11 aldo-keto reductases. J. Mol. Biol. 337:661-673
Kavanagh KL, Elling RA, Wilson DK (2004) The structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use. Biochemistry 43:879-889
Voegtli WC, Madrona AY, Wilson DK (2003) The structure of Aip1p, a WD repeat protein that enhances actin depolymerization. J. Biol. Chem. 278:34373-34379.
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK. (2003) The structure of xylose reductase bound to NAD+ and the basis for single and dual cosubstrate specificity in family 2 aldo-keto reductases. Biochem. J. 373:319-326
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK. (2002) Crystal structure of Pseudomonas fluorescens Mannitol 2-dehydrogenase binary and ternary complexes: specificity and catalytic mechanism. J. Biol. Chem. 277:43433-43442.
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK (2002) The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis. Biochemistry 41:8785-8795.
Laboratory Personnel:
3 Briggs
Postdocs: Eric di Luccio;
Grad Students: Erin Chew (CHEM), Mark Wogulis (BMB);
Technicians: Rob Elling;
Undergraduate: Andy Ehrensberger
Visiting: Stefan Leitgeb (Technische Universitaet Graz)