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James Hildreth


Molecular & Cellular Biology

207 Life Sciences
+1 530 752 6764


1987 MD Johns Hopkins University Medicine
1982 PhD Oxford University Immunology
1979 BA Harvard University Chemistry

Research Interests:

My laboratory research is focused on understanding mechanisms by which HIV subverts host pathways and molecules during its replication cycle. We are particularly interested in the role of cholesterol and cholesterol homeostatic pathways in virus entry, virus release and viral gene transcription. The involvement of cholesterol-rich lipid rafts, late endosomes and exosomes is also the subject of investigations in our laboratory. Another major area of interest is the impact of viral co-infections on HIV’s tropism and replication. Many viruses are known to modulate cholesterol regulatory pathways and cellular cholesterol content and thereby can profoundly affect HIV replication. We are interested in this and other mechanisms of enhancement or suppression of HIV transmission and replication by co-infecting viruses.


Rhodes Scholar
Alpha Omega Alpha
NSF Presidential Young Investigator
Institute of Medicine
NIH Director’s Pioneer Award

Professional Societies:

American Society of Microbiology

CBS Graduate Group Affiliations:

Biochemistry, Molecular, Cellular and Developmental Biology  

Specialties / Focus:

Biochemistry, Molecular, Cellular and Developmental Biology
Molecular Medicine



Last updated 9/29/2011
Cooper J, Liu L, Woodruff EA, Taylor HE, Goodwin JS, D'Aquila RT, Spearman P, Hildreth JE, Dong X. (2011). Filamin a interacts with human immunodeficiency virus type 1gag and contributes to productive particle assembly. J Biol Chem. 286(32):28498-510. PMID: 21705339

Taylor HE, Linde ME, Khatua AK, Popik W, Hildreth JE. (2011). Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol. 85(15):7699-709. PMID: 21613400

Shao Q, Wang Y, Hildreth JE, Liu B. (2010). Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif. J Virol. 2010. 84(9):4840-4. PMID: 20147392

Khatua AK, Taylor HE, Hildreth JE, Popik W. (2010). Non-productive HIV-1 infection of human glomerular and urinary podocytes. Virology. 408(1):119-27. PMID: 20937511

Atanu K. Khatua, Harry E. Taylor, James E.K. Hildreth, Waldemar Popik. (2010). Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F. Virology. 400(1):68-75

Tang Y, Leao IC, Coleman EM, Broughton RS, Hildreth JE. (2009). Deficiency of Niemann-Pick type C-1 Protein Impairs HIV-1 Release and Results in Gag Accumulation in Late Endosomal/Lysosomal Compartments. J Virol. 83(16):7982-95

Khatua AK, Taylor HE, Hildreth JE, Popik W. (2009). Exosomes packaging APOBEC3G confer HIV-1 resistance to recipient cells. J Virol. 83(2):512-2

Kitabwalla M, Ansari AA, Villinger F, Akeefe H, Conner AP, Mayne AE, Hildreth JE. (2008). Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment. Exp Biol Med (Maywood). 233(6):732-40

Nguyen, D.G., A.M. Booth, S.J. Gould, and J.E.K. HILDRETH. (2003). Evidence that HIV Budding in Primary Macrophages Utilizes the Exosome Release Pathway. J. Biol. Chem. 278(52):52347-54

Gould, S.J., A.M. Booth, and J.E.K. HILDRETH. (2003). The Trojan Exosome Hypothesis. Proc. Nat. Acad Sci USA 100:10592-10597

Graham, D.R., E. Chertova, J. Hilburn, L.O. Arthur, and J.E.K. HILDRETH. (2003). Cholesterol Depletion of HIV-1 and SIV with Beta-Cyclodextrin Inactivates and Permeabilizes the Virions: Evidence for Virion-Associated Lipid Rafts. J Virol 77:8237-8248

Liao, Z., D.R. Graham, and J.E.K. HILDRETH. (2003). Lipid Rafts and HIV-1 Pathogenesis Virion-Associated Cholesterol Is Required for Fusion and Infection of Susceptible Cells. AIDS Res Human Retroviruses 19:675-687

Khanna, K.V., KJ Whaley, L. Zeitlin, T.R. Moench, K. Mehrazar, R.A. Cone, Z. Liao, J.E.K. HILDRETH, T.E. Hoen, L. Shultz, and R.B. Markham. (2002). Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent. J Clin Invest. 109:205-11

Liao, Z., L. Cimakasky, D. Nguyen, R. Hampton, and J.E.K. HILDRETH. (2001). Lipid Rafts and HIV-1 Pathogenesis: Cholesterol is required for HIV-1 Infectivity. AIDS Res. Hum. Retroviruses 17:1009-1019