Research Contribution to Society:
My laboratory is aggressively pursuing basic research activities to understand the molecular mechanisms by which plant immune receptors recognize pathogens and initiate innate immune signaling. In addition, we are interested in understanding the role of autophagy in innate immunity and programmed cell death (PCD). Towards these goals, we are taking multiple complementary approaches including new forward and reverse genetic screens, sophisticated biochemical and imaging approaches, and innovative genomics and proteomics approaches.
Research Interests:
Host-pathogen interactions;
Programmed cell death;
Autophagy;
Immune signaling;
Pathogen effector biology;
Protein microarrays;
Genomics and Proteomics
Department and Center Affiliations:
Genome Center
Professional Societies:
American Society of Plant Biology
CBS Graduate Group Affiliations:
Plant Biology
Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus:
Biochemistry, Molecular, Cellular and Developmental Biology
Plant Biology
Molecular Biology, Biochemistry, and Genomics
Publications:
Last updated 5/1/2013
Padmanabhan M, Ma S, Burch-Smith T, Czymmek K, Huijser P, and Dinesh-Kumar SP (2013) Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity. PLoS Pathogens 9(3):e1003235.
Ma S, Bachan S, Porto M, Bohnert HJ, Snyder M, Dinesh-Kumar SP. (2012) Discovery of stress responsive DNA regulatory motifs in Arabidopsis. PLoS ONE 7:e43198.
Hayward, AP and Dinesh-Kumar, SP (2011) What can Plant Autophagy do for an Innate Immune Response? Annu Rev Phytopathol. 49:557-576
Lee, H.Y., Bowen, C.H., Popescu, G.V., Kang, H., Kato, N., Ma, S., Dinesh-Kumar, S.P., Snyder, M., and Popescu, S.C. (2011) Arabidopsis RTNLB1 and RTNLB2 reticulon-like proteins regulate intracellular trafficking and activity of the FLS2 immune receptor. Plant Cell 23:3374-3391.
Zhu X, Caplan JC, Mamillapalli P, Czymmek K, and Dinesh-Kumar SP (2010) Function of endoplasmic reticulum calcium ATPase in innate immunity mediated programmed cell death. EMBO J 29, 1007-1018.
Padmanabhan M, and Dinesh-Kumar SP (2010) All Hands on Deck - the Role of Chloroplasts, ER and Nucleus in Driving Plant Innate Immunity. Mol Plant Microbe Interact 23, 1368-1380.
Zhu X, Pattathil S, Mazumder K, Brehm A, Hahn M, Dinesh-Kumar SP, and Joshi C. (2010) Virus-induced gene silencing offers a functional genomics platform for studying plant cell wall formation. Mol Plant 3, 818-833. (Cover Article).
*Caplan JC, *Zhu X, (contributed equally), Mamillapalli P, Marathe R, Anandalakshmi R, and Dinesh-Kumar SP. (2009) Induced ER-chaperones regulate a receptor-like kinase to mediate anti-viral innate immune response in plants. Cell Host Microbe 6, 457-469.
Popescu SC, Popescu GV, Bachan S, Zhang Z, Gerstein M, Snyder M, and Dinesh-Kumar SP. (2009) MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Genes Develop 23:80-92.
Caplan JC, Mamillapalli P, Burch-Smith TM, Czymmek K, and Dinesh-Kumar SP. (2008) Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector. CELL 132:449-462.
Caplan JC, Padmanabhan M, and Dinesh-Kumar SP. (2008) Plant NB-LRR immune receptors: From recognition to transcriptional reprogramming. Cell Host Microbe 3:126-135.
Patel S, and Dinesh-Kumar SP. (2008) Arabidopsis ATG6 is required to limit the pathogen-associated cell death response. Autophagy 4:20-27.
Burch-Smith TM, Schiff M, Caplan J, Tsao J, Czymmek K, and Dinesh-Kumar SP. (2007) A novel role for the TIR domain in association with pathogen-derived elicitors. PLoS Biol 5:e68:501-514.
*Burch-Smith TM, *Schiff M, *Liu Y, (*contributed equally) and Dinesh-Kumar SP. (2006) Efficient virus induced gene silencing in Arabidopsis thaliana. Plant Physiol 142:21-27.
Liu Y, Schiff M, Czymmek K, Talloczy Z, Levine B, Dinesh-Kumar SP. (2005) Autophagy regulates programmed cell death during the plant innate immune response. Cell 121:567-577.
Laboratory Personnel:
Dinesh-Kumar
http://dinesh-kumarlab.genomecenter.ucdavis.edu/
Meenu Padmanabhan - Post-doc
Shisong Ma - Post-doc
Jongchan Woo - Post-doc
Amanda Carter - Junior Specialist
Smit Shah - Junior Specialist
Tuan Vo - Junior Specialist
Jeffrey Susila - Undergraduate Student
Varsha Prasad - Undergraduate Student
Arthur Leck - High School Student
Courses:
Cell Biol
BIS104
Cell Biology
Spring
Genomics
BIS180L
Genomics Laboratory
Spring