Leonor Saiz
Assistant Professor
lsaiz@ucdavis.edu
Biomedical Engineering (Grad)
Office
2315 GBSF, Davis, CA 95616
+1 530 752 6700
Degrees:
1998
PhD
University of Barcelona
Physics
Awards:
Editorial Board member, Journal of Membrane Biology
Department and Center Affiliations:
Department of Biomedical Engineering
Professional Societies:
Biophysical Society
American Physical Society
American Chemical Society
Biomedical Engineering Society
CBS Graduate Group Affiliations:
Biophysics
Graduate Groups not Housed in CBS:
Biomedical Engineering Graduate Group
Publications:
Last updated 5/31/2013
(Selected publications)
D. Nicklas and L. Saiz, Computational modeling of smad-mediated negative feedback and crosstalk in the TGF-β superfamily network, J. R. Soc. Interface, in press (2013).
J.M.G. Vilar and L. Saiz, Reliable prediction of complex phenotypes from a modular design in free energy space: an extensive exploration of the lac operon, ACS Synthetic Biology, in press (2013)
J.M.G. Vilar and L. Saiz, Systems Biophysics of Gene Expression, Biophys. J., in press (2013)
L. Saiz, The physics of protein-DNA interaction networks in the control of gene expression, Journal of Physics: Condensed Matter, 24, 193102 (2012).
J.M.G. Vilar and L. Saiz, Trafficking coordinate description of intracellular transport control of signaling networks, Biophys. J., 101, 2315-2323 (2011).
J.M.G. Vilar and L. Saiz, Control of gene expression by modulated self-assembly, Nucleic Acids Research, 39, 6854-6863 (2011).
J.M.G. Vilar and L. Saiz, CplexA: a Mathematica package to study macromolecular-assembly control of gene expression, Bioinformatics, 26, 2060-2061 (2010).
L. Saiz and J.M.G. Vilar, Protein-protein/DNA interaction networks: versatile macromolecular structures for the control of gene expression, IET Systems Biology, 2, 247-255 (2008).
L. Saiz and J.M.G. Vilar, Ab initio thermodynamic modeling of distal multisite transcription regulation, Nucleic Acids Research, 36, 726-731 (2008).
L. Saiz and J.M.G. Vilar, Multilevel deconstruction of the in vivo behavior of looped DNA-protein complexes, PLoS One, 2(4): e355. doi:10.1371/journal.pone.0000355 (2007).
S. Vemparala, L. Saiz, R.G. Eckenhoff, and M.L. Klein, Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundles, Biophys. J., 91, 2815-2825 (2006).
J.M.G. Vilar and L. Saiz, Multiprotein DNA looping, Phys. Rev. Lett., 96, 238103 (2006).
L. Saiz and J.M.G. Vilar, DNA looping: the consequences and its control, Curr. Opin. Struct. Biol., 16, 344-350 (2006).
L. Saiz and J.M.G. Vilar, Stochastic dynamics of macromolecular-assembly networks, Molecular Systems Biology, 2, doi:10.1038/msb4100061 (2006).
L. Saiz, J.M. Rubi, and J.M.G. Vilar, Inferring the in vivo looping properties of DNA, Proc. Natl. Acad. Sci. USA, 102, 17642-17645 (2005).
J.M.G. Vilar and L. Saiz, DNA looping in gene regulation: From the assembly of macromolecular complexes to the control of transcriptional noise, Current Opinion in Genetics & Development, 15, 136-144 (2005).
L. Saiz and M.L. Klein, The transmembrane domain of the acetylcholine receptor: Insights from simulations on synthetic peptide models, Biophys. J., 88, 959-970 (2005).
M. Pickholz, L. Saiz, and M.L. Klein, Concentration effects of volatile anesthetics on the properties of model membranes: A coarse-grain approach, Biophys. J., 88, 1524-1534 (2005).
L. Saiz, S. Bandyopadhyay, and M.L. Klein, Effect of the pore region of a transmembrane ion-channel on the physical properties of a simple membrane, J. Phys. Chem. B, 108, 2608-2613 (2004).
L. Koubi, L. Saiz, M. Tarek, D. Scharf, and M.L. Klein, Influence of anesthetic and nonimmobilizer molecules on the physical properties of a polyunsaturated lipid bilayer, J. Phys. Chem. B 107, 14500-14508 (2003).
L. Saiz, S. Bandyopadhyay, and M.L. Klein, Towards an understanding of complex biological membranes from atomistic molecular dynamics simulations, Bioscience Reports 22, 151-173 (2002).
L. Saiz and M.L. Klein, Computer simulation studies of model biological membranes, Accounts of Chemical Research 35, 482-489 (2002).
L. Saiz and M.L. Klein, Electrostatic interactions in a neutral model phospholipid bilayer by molecular dynamics simulations, J. Chem. Phys. 116, 3052-3057 (2002).
L. Saiz and M.L. Klein, Influence of highly polyunsaturated lipid acyl chains of biomembranes on the NMR order parameters, J. Am. Chem. Soc. 123, 7381-7387 (2001).
L. Saiz and M.L. Klein, Structural properties of a highly polyunsaturated lipid bilayer from molecular dynamics simulations, Biophys. J. 81, 204-216 (2001).
Courses:
BIM
105
Probability, Stochastic Processes, and Statistics for Biomedical Engineers
(Fall)
BIM
289C
Molecular Systems Biology and Biomedicine
(Spring)
BIM
152
Molecular Control of Biosystems
(Spring)