Barbara L. Shacklett
Associate Professor
blshacklett@ucdavis.edu

Microbiology - Medicine
Infectious Diseases (Int Med)

Office
Tupper Hall, Davis, CA 95616
+1 530 752 6785


Picture of Barbara Shacklett
 
Degrees:
1994 PhD University of California, Davis Microbiology
1985 BS Cook College, Rutgers University Microbiology
Awards:
Selman A. Waksman Award in Microbiology, Cook College, Rutgers University (1985)
Regents Predoctoral Fellowship, UC Davis (1988-1990)
Earle C. Anthony Predoctoral Fellowship, UC Davis (1990-1991)
Postdoctoral Fellowship, Agence Nationale de Recherches sur le SIDA (ANRS, Paris, France) (1994-1996)
Postdoctoral Fellowship, Fondation Pour la Recherche Medicale (SIDACTION, Paris, France) (1996-1997)
Department and Center Affiliations:
Member, UC Davis Cancer Center
Member, California Center for the Biology of HIV in Minorities
Professional Societies:
Society for Mucosal Immunology
American Society for Microbiology
American Association of Immunologists
International AIDS Society
CBS Graduate Group Affiliations:
Genetics  
Graduate Groups not Housed in CBS:
Immunology  
Microbiology  
Publications:
  • Critchfield JW, Lemongello D, Walker DH, Garcia JC, Asmuth DM, Pollard RB, Shacklett BL. Multifunctional HIVgag specific CD8+ T-cell responses in rectal mucosa and PBMC during chronic HIV-1 infection. Journal of Virology 81:5460-71. 2007
  • Zuber B, Quigley MF, Critchfield JW, Shacklett BL, Abel K, Miller CJ, Morner A, Paulie S, Ahlborg N, Sandberg, JK. Detection of macaque perforin expression and release by flow cytometry, immunohistochemistry, ELISA and ELISpot. J. Immunol. Methods 312:45-53. 2006
  • Quigley MF, Abel K, Miller CJ, Zuber B, Sandberg JK, Shacklett BL. Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection. Journal of Virology 80:3083-7. 2006
  • Nixon DF, Deeks SG, Shacklett BL, Karlsson AC. Multidrug-resistant, dual-tropic HIV-1 and rapid progression (correspondence). Lancet 365:1924-5. 2005
  • Roland ME, Neilands TB, Krone MR, Katz MH, Grant R, Busch MP, Hecht F, Shacklett BL, Kahn JO, Bamberger JD, Coates TJ, Martin JN. Seroconversion following non-occupational post-exposure prophylaxis against human immunodeficiency virus. Clinical Infectious Diseases 41:1507-13. 2005
  • Shacklett BL, Cox CA, Quigley M, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon DF. Abundant granzyme A, but not perforin, in cytolytic granules of CD8+ T-cells in gut-associated lymphoid tissue (GALT): Implications for immune control of HIV-1 infection. Journal of Immunology 173:641-8. 2004
  • Shacklett BL, Cox CA, Wilkens DT, Karlsson RK, Nilsson A, Nixon DF, Price RW. Increased adhesion molecule and chemokine receptor expression on CD8+ T-cells trafficking to cerebrospinal fluid in HIV infection. Journal of Infectious Diseases 189:2202-12. 2004
  • Karlsson RK, Nixon DF, Shacklett BL. Poorly soluble peptides can mimic authentic ELISPOT responses (Research Letter). Journal of Immunological Methods, 285:89-92. 2004
  • Chandwani R, Jordan KA, Shacklett BL, Papasavvas E, Rosenberg MG, Montaner LJ, Nixon DF, Sandberg JK. Immunodominance in the HLA-A2 restricted CD8 T cell response to Nef in HIV-1 infected children and adults. Scandinavian Journal of Immunology, 59:109-14. 2004
  • Shacklett BL, Yang O, Hausner MA, Elliott J, Hultin L, Price C, Fuerst M, Matud J, Hultin P, Cox C, Ibarrondo J, Wong J, Nixon DF, Anton P, Jamieson BD. Optimization of methods to assess human mucosal immune responses to HIV vaccination and infection. Journal of Immunological Methods 279:17-31. 2003
  • Shacklett BL, Cox CA, Sandberg JK, Jacobson MA, Stollman NH, Nixon DF. Trafficking of HIV-1-specific CD8+ T-cells to gut-associated lymphoid tissue (GALT) during chronic infection. Journal of Virology 77:5621-5631. 2003
Laboratory Personnel:
Shacklett Lab/Tupper Hall 3324
http://www.ucdmc.ucdavis.edu/medmicro/staff/shacklett.html
Bill Critchfield, PhD (Asst Project Scientist); Bridget McLaughlin, MS (Analyst); Donna Lemongello (SRA); Delandy Young (SRA); Jennie Zhang (Student Assistant); Melissa Schreiber, Division of Infectious Diseases, Sacramento (Clinical Study Coordinator); Graduate Students: April Ferre, Microbiology; Tim Hayes, Immunology; Julia Stockhausen, Microbiology.

Recent Visitors

Mohanakrishnan Janardhanan, YRG CARE laboratory, Chennai, India; Maire Quigley, Karolinska Institutet, Stockholm, Sweden; Alix Scholer, Ecole Normale Superieure, Paris, France.

Teaching Interests:
Microbiology, Host-Pathogen Interactions, Virology, Mucosal Immunology, General and Clinical Immunology
Courses:
IMM 297 Mucosal Immunology Spring
MMI 480A Medical Immunology (MD students only) Winter
MMI 188 Human Immunology Winter
MMI 200D Mechanisms for Microbial Interactions With Hosts Winter