Degrees:
1994
PhD
University of Illinois
Nutritional Sciences
1991
MS
UC, Santa Cruz
Marine Sciences
1988
BA
California State University, Fresno
Biology
Research Interests:
Dr. Adams investigates the etiology of obesity and related metabolic disorders such as diabetes. Research efforts explore which molecular markers and endocrine factors correlate with indices of metabolic health in human nutritional studies and in animal models of obesity, with a primary focus on fat cell physiology and bioactive metabolites emerging from metabolomics studies.
Department and Center Affiliations:
USDA-ARS Western Human Nutrition Research Center
Department of Nutrition
Professional Societies:
American Society for Nutrition (ASN)
American Physiological Society (APS)
The Obesity Society
CBS Graduate Group Affiliations:
Molecular, Cellular, and Integrative Physiology
Graduate Groups not Housed in CBS:
Graduate Group in Nutrition (GGNB)
Publications:
Last updated 5/21/2010
P.J. Oort, C.H. Warden, T.K. Baumann, T.A. Knotts, and S. H. Adams. Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons. Mol. Cell. Endocrinology, 276(1-2):24-35, 2007
S. H. Adams, C. Lei, C.M. Jodka, S.E. Nikoulina, J.A. Hoyt, B. Gedulin, C.M. Mack, and E.S. Kendall. PYY[3-36] administration decreases the respiratory quotient and reduces adiposity in diet-induced obese mice. J. Nutrition, 136: 195-201, 2006
S.H. Adams, Wesley B. Won, S.E. Schonhoff, A.B. Leiter, and J.R. Paterniti, Jr. Effects of PYY[3-36] on short-term food intake in mice are not affected by prevailing plasma ghrelin levels. Endocrinology, 145:4967-4975, 2004
G. Perdomo, S.R. Cummerford, S.H. Adams, R.M. O'Doherty, and N.F. Brown. Increased Beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid induced insulin resistance despite intramyocellular lipid accumulation. J. Biol. Chem., 279(26):27177-27186, 2004
Fu, L., L. John, S.H. Adams, X.X. Yu, E. Tomlinson, M. Renz, P.M. Williams, R. Soriano, R. Corpuz, M. Moffat, R. Vandlen, L. Simmons, J. Foster, J-P. Stephan, S.P. Tsai, and T.A. Stewart. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin deficient diabetes. Endocrinology, 145(6):2594-2603, 2004
Yu, X.X., D.A. Lewin, W. Forrest, & S.H. Adams. Cold elicits the simultaneous induction of fatty acid synthesis & beta-oxidation in rodent brown adipose tissue. Prediction from differential gene expression & confirmation in vivo. FASEB J.16: 155-168, 2002
Adams, S.H., C. Chui., S.L. Schilbach, X.X. Yu, A.D. Goddard, J.C. Grimaldi, J. Lee, P. Dowd, S. Colman, & D.A. Lewin. BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue. Cloning, organization of the human gene, & assessment of a potential link to obesity. Biochem. J. 360: 135-142, 2001
Adams, S.H., G. Pan, & X.X. Yu. Perspectives on the biology of UCP homologues. Invited contribution for Biochem. Soc. Transactions 29(6): 798-802, 2001
Yu, X.X., D.A. Lewin, A. Zhong, J. Brush, P.W. Schow, S.W. Sherwood, G. Pan, & S.H. Adams. Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69. Biochem. J. 353: 369-375, 2001
Adams, S.H. Uncoupling protein homologs: emerging views of physiological function. Recent Advances in Nutritional Sciences, J. Nutr. 130: 711-714, 2000
Yu, X.X., J.L. Barger, B.B. Boyer, M.D. Brand, G. Pan, and S.H. Adams. Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, & mitochondrial proton leak kinetics. Am. J. Physiol. Endocrinol. Metab. 279: E433-E446, 2000
Yu, X.X., W. Mao, A. Zhong, P. Schow, J. Brush, S.W. Sherwood, S.H. Adams, and G. Pan. Characterization novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB J. 14(11): 1611-1618, 2000
Mao, W., X.X. Yu, A. Zhong, W. Li, J. Brush, S.W. Sherwood, S.H. Adams, and G. Pan. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Letters 443: 326-330, 1999
Adams, S.H., V. Esser, N.F. Brown, N.H. Ing, L . Johnson, D.W. Foster, and J.D. McGarry. Expression and possible role of muscle-type carnitine palmitoyltransferase I during sperm development in the rat. Biol. of Reprod. 59: 1399-1405, 1998
Adams, S.H. and J. Odle. Acetogenesis does not replace ketogenesis in fasting piglets infused with hexanoate. Am. J. Physiol. Endocrinol. Metab. 274: E963-E970, 1998
Adams, S.H., C. Sampaio Alho, G. Asins, F.G. Hegardt, and P.F. Marrero. Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet. Biochem. J. 324: 65-73, 1997
Adams, S.H., X. Lin, X.X. Yu, J. Odle, and J.K. Drackley. Hepatic fatty acid metabolism in pigs and rats: major differences in endproducts, O2 uptake, and beta-oxidation. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 272: R1641-R1646, 1997
Lin, X., S.H. Adams, and J. Odle. Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. Biochem. J. 318: 235-240, 1996
Ortiz, R.M., S.H. Adams, D.P. Costa, and C.L. Ortiz. Plasma vasopressin levels and water conservation in fasting, postweaned northern elephant seal pups (Mirounga angustirostris). Marine Mammal Sci. 12: 99-106, 1996
Odle, J., T.A.T.G. van Kempen, J.K. Drackley, and S.H. Adams. Carnitine palmitoyltransferase modulation of hepatic fatty acid metabolism and radio-HPLC evidence for low ketogenesis in neonatal pigs. J. Nutr. 125: 2541-2549, 1995
Tetrick, M.A., S.H. Adams, J. Odle, and N.J. Benevenga. Contribution of D-(-)-3-hydroxybutyrate to the energy expenditure of neonatal pigs. J. Nutr. 125: 264-272, 1995
Patterson-Buckendahl, P., S.H. Adams, R. Morales, W.S.S. Jee, C.E. Cann, and C.L. Ortiz. Skeletal development in newborn and weanling northern elephant seals. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 267: R726-R734, 1994
Adams, S.H. and J. Odle. Plasma beta-hydroxybutyrate after octanoate challenge: attenuated ketogenic capacity in neonatal swine. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 265: R761-R765, 1993
Adams, S.H. and D.P. Costa. Water conservation and protein metabolism in northern elephant seal pups during the postweaning fast. J. Comp. Physiol. B 163: 367-373, 1993
Adams, S.H., D.P. Costa, & S.C. Winter. Plasma carnitine in fasting neonatal and adult northern elephant seals. Am. J. Physiol. Endocrinol. Metab. 263: E570-E574, 1992
Laboratory Personnel:
WHNRC
Pieter J. Oort, Molecular Biologist; Trina A. Knotts, Ph.D., USDA Postdoctoral Fellow; Tamara N. Dunn, GGNB Ph.D. Student; Colin S. McCoin, MCIP Ph.D. student; Daniel Bedinger, MCIP Ph.D. student; Dorothy Kieffer, GGNB Ph.D. student