Robert Brosnan
Associate Professor
rjbrosnan@ucdavis.edu
VM Surgical & Radiological Sci
Office
1306 Tupper Hall
+1 530 754 6476
Lab
1110 Tupper Hall
+1 530 752-0111
Degrees:
2004
Diploma
American College of Veterinary Anesthesiologists
2002
PhD
University of California, Davis
Physiology
1999
DVM
University of California, Davis
Veterinary Medicine
1994
BS
University of California, Los Angeles
Biology
Research Interests:
Anesthetic Mechanisms of Action
Cardiorespiratory Effects of Anesthetics
Professional Societies:
American College of Veterinary Anesthesiologists
American Physiological Society
American Veterinary Medical Association
CBS Graduate Group Affiliations:
Molecular, Cellular, and Integrative Physiology
Graduate Groups not Housed in CBS:
Comparative Pathology, Pharmacology and Toxicology
Publications:
Last updated 1/18/2012
Brosnan RJ, Steffey EP, Escobar A, Palazoglu M, Fiehn O. Anesthetic induction with guaifenesin and propofol in adult horses. Am J Vet Res. 2011 Dec;72(12):1569-75.
Pypendop BH, Brosnan RJ, Ilkiw JE. Use of naltrexone to antagonize high doses of remifentanil in cats: a dose-finding study. Vet Anaesth Analg. 2011 Nov;38(6):594-7.
Brosnan RJ. GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentration. Vet Anaesth Analg. 2011 May;38(3):231-9.
Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5093-7.
Aleman M, Williams DC, Jorge NE, Magdesian KG, Brosnan RJ, Feary DJ, Hilton HG, Kozikowski TA, Higgins JK, Madigan JE, Lecouteur RA. Repetitive stimulation of the common peroneal nerve as a diagnostic aid for botulism in foals. J Vet Intern Med. 2011 Mar;25(2):365-72.
Brosnan RJ, Pham TL. Does anesthetic additivity imply a similar molecular mechanism of anesthetic action at N-methyl-d-aspartate receptors? Anesth Analg. 2011 Mar;112(3):568-73.
Brosnan RJ, Steffey EP, LeCouteur RA, Esteller-Vico A, Vaughan B, Liu IK. Effects of isoflurane anesthesia on cerebrovascular autoregulation in horses. Am J Vet Res. 2011 Jan;72(1):18-24.
Brosnan RJ, Steffey EP, Esteller-Vico A, Vaughan B, Liu IK. The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses. Res Vet Sci. 2011 Feb;90(1):138-45.
Steffey EP, Brosnan RJ, Galuppo LD, Mama KR, Imai A, Maxwell LK, Cole CA, Stanley SD. Use of propofol-xylazine and the Anderson Sling Suspension System for recovery of horses from desflurane anesthesia. Vet Surg. 2009 Dec;38(8):927-33.
Brosnan RJ, Pypendop BH, Siao KT, Stanley SD. Effects of remifentanil on measures of anesthetic immobility and analgesia in cats. Am J Vet Res. 2009 Sep;70(9):1065-71.
Brosnan RJ, Steffey EP. Sedative effects of propofol in horses. Vet Anaesth Analg. 2009 Sep;36(5):421-5.
Steffey EP, Mama KR, Brosnan RJ, Imai A, Maxwell LK, Cole CA, Stanley SD. Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane. Am J Vet Res. 2009 Aug;70(8):956-63.
McKune CM, Brosnan RJ, Dark MJ, Haldorson GJ. Safety and efficacy of intramuscular propofol administration in rats. Vet Anaesth Analg. 2008 Nov;35(6):495-500.
Brosnan RJ, Pham TL. Carbon dioxide negatively modulates N-methyl-D-aspartate receptors. Br J Anaesth. 2008 Nov;101(5):673-9.
Brosnan RJ, Esteller-Vico A, Steffey EP, LeCouteur RA, Liu IK, Vaughan B. Effects of head-down positioning on regional central nervous system perfusion in isoflurane-anesthetized horses.
Am J Vet Res. 2008 Jun;69(6):737-43.
Pypendop BH, Brosnan RJ, Siao KT, Stanley SD. Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane.
Am J Vet Res. 2008 Apr;69(4):531-6.
Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone. Anesth Analg. 2007 Sep;105(3):673-9.
Yang L, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. 2007 Aug;105(2):393-6.
Brosnan RJ, Eger EI 2nd, Laster MJ, Sonner JM. Anesthetic properties of carbon dioxide in the rat. Anesth Analg. 2007 Jul;105(1):103-6.
Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner JM. Ammonia has anesthetic properties. Anesth Analg. 2007 Jun;104(6):1430-3.
Brosnan RJ, Pypendop BH, Barter LS, Hawkins MG. Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana). Am J Vet Res. 2006 Oct;67(10):1670-4.
Brosnan RJ, Pypendop BH. A technique to depress desflurane vapor pressure. Vet Anaesth Analg. 2006 Sep;33(5):275-80.
Won A, Oh I, Brosnan R, Eger EI 2nd, Sonner JM. Hypothermia decreases ethanol MAC in rats. J Anesth. 2006; 20(3): 247-50.
Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI 2nd, Sonner JM. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul;103(1):86-91
Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI 2nd. The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg. 2006 May;102(5):1419-26.
Barter LS, Hawkins MG, Brosnan RJ, Antognini JF, Pypendop BH. Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas. Am J Vet Res. 2006 Mar;67(3):392-7.
Solano AM, Brosnan RJ, Steffey EP. Rate of change of oxygen concentration for a large animal circle anesthetic system. Am J Vet Res. 2005 Oct;66(10):1675-8.
Aleman M, Brosnan RJ, Williams DC, LeCouteur RA, Imai A, Tharp BR, Steffey EP. Malignant hyperthermia in a horse anesthetized with halothane. J Vet Intern Med. 2005 May-Jun;19(3):363-6.
Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Farver TB. Intracranial elastance in isoflurane-anesthetized horses. Am J Vet Res. 2004 Aug;65(8):1042-6.
Brosnan RJ, Steffey EP, LeCouteur RA, Farver TB, Imai A. Effects of duration of isoflurane anesthesia and mode of ventilation on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Nov;64(11):1444-8.
Steffey MA, Brosnan RJ, Steffey EP. Assessment of halothane and sevoflurane anesthesia in spontaneously breathing rats. Am J Vet Res. 2003 Apr;64(4):470-4.
Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. Effects of ventilation and isoflurane end-tidal concentration on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Jan;64(1):21-5.
Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Kortz GD. Direct measurement of intracranial pressure in adult horses. Am J Vet Res. 2002 Sep;63(9):1252-6.
Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses. J Appl Physiol. 2002 Jun;92(6):2542-6.
Teaching Interests:
Anesthesiology
Cardiorespiratory and Comparative Physiology
Anesthetic Pharmacology
Courses:
VSR
466
Large Animal Applied Anesthesiology
Winter
VSR
491R
Anesthesia/Critical Care Basic Science Management Conference
Fall,Winter,Spring
VSR
493R
Anesthesia/Critical Care Clinical Case Management Conference
Fall,Winter,Spring
VSR 469
Equine Surgery
Winter
VSR 469L
Equine Surgery Laboratory
Winter
VMD 407L
Principles and Techniques of Surgery and Anesthesia Laboratory
Winter,Spring
VSR
494R
Anesthesia/Critical Patient Care Journal Discussion
Fall, Winter, Spring