UC Davis Home | Students | Faculty | Alumni & Friends | Giving
Picture of Paramita M Ghosh

 

Paramita Mitra Ghosh

Associate Professor
paghosh@ucdavis.edu


Biochemistry and Molecular Medicine
Urology - Medicine

Office
Rm 2200A, Research III, UC Davis Medical Center
+1 916 734 7805

Office
Bldg 722, Rm 121, VA Northern California, Mather, CA
+1 916 843 9336
+1 916 275 3246



Degrees:

1994 PhD Rensselaer Polytechnic Institute Chemistry
1989 MS Jadavpur University, Calcutta, INDIA Physics
1987 BS Jadavpur University, Calcutta, INDIA Physics

Research Interests:

Signal Transduction Pathways in Prostate Cancer
The pathways we study include the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, the Ras/Raf/MEK/MAPK pathway and other signaling pathways both upstream and downstream of these. This includes the mammalian target of rapamycin (mTOR) pathway, and signaling by the epidermal growth factor receptor (EGFR), related receptor tyrosine kinases ErbB2 and ErbB3.


Awards:

2000 WICR Young Investigator Scholar Award. American Association for Cancer Research
1997-1999 NIH Postdoctoral Training Award. Department of Pathology, University of Texas Health Science Center at San Antonio, TX.
1989-1994 Tuition Scholarship and Graduate Assistantship. Rensselaer Polytechnic Institute, Troy, NY
1989 Gold Medal for Excellence, Master of Science. Department of Physics, Jadavpur University, Calcutta 700032, India
1989 S.N. Bose Medal for best academic achievement. Department of Physics, Jadavpur University, Calcutta 700032, India.
1983-1989 National Science Scholarship. University Grants Commission, Government of India
2006 UC Davis Academic Federation Travel Award
2006 Best Poster Award. International Symposium on Hormonal Carcinogenesis, Montpellier, France

Department and Center Affiliations:

Department of Urology, School of Medicine
UC Davis Cancer Center
Department of Biochemistry and Molecular Medicine

Professional Societies:

American Association for Cancer Research
Society of Basic Urological Research
American Association for the Advancement of Science
American Urological Association

CBS Graduate Group Affiliations:

Biochemistry, Molecular, Cellular and Developmental Biology  
Genetics  

Specialties / Focus:

Biochemistry, Molecular, Cellular and Developmental Biology
Molecular Medicine
Signal Transduction and Gene Regulation

Genetics
Human Genetics

Graduate Groups not Housed in CBS:

Pharmacology and Toxicology Graduate Group  
Comparative Pathology  

Publications:

Last updated 1/27/2012
Chen L, Mooso BA, Jathal MK, Madhav A, Johnson SD, van Spyk E, Mikhailova M, Zierenberg-Ripoll A, Xue L, Vinall RL, deVere White RW, Ghosh PM. Dual EGFR/HER2 inhibition sensitizes prostate cancer cells to androgen withdrawal by suppressing ErbB3. Clin Cancer Res. 2011 Oct 1; 17 (19):6218-28.
 

Vinall RL, Mahaffey CM, Davis RR, Luo Z, Gandour-Edwards R, Ghosh PM, Tepper CG, de Vere White RW. Dual blockade of PKA and NF-B inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis. Horm Cancer. 2011 Aug; 2 (4):224-38. PubMed PMID: 21789713.
 

Jathal MK, Chen L, Mudryj M, Ghosh PM. Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block. Immunol Endocr Metab Agents Med Chem. 2011 Jun; 11 (2):131-149. PubMed PMID: 21603064
 

Roy M, Kung HJ, Ghosh PM. Statins and prostate cancer: role of cholesterol inhibition vs prevention of small GTP-binding proteins. Am J Cancer Res. 2011; 1 (4):542-61. PubMed PMID: 21984972.
 

Ghosh PM. What controls PTEN and what it controls (in prostate cancer). Asian J Androl. 2011 Sep 26; PubMed PMID: 21946231.
 

Chen H, Libertini SJ, Wang Y, Kung HJ, Ghosh P, Mudryj M. ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines. J Biol Chem. Jan 22;285(4):2368-74. 2010
 

Chen, L, Lu, X.-H., Shi, X.-B., R., deVere White, RW, Carraway, K.L. III and Ghosh, PM. Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate–resistant prostate cancer cells. Cancer Research. 70(14):5994-6003, 2010.
 

Mooso, B., Madhav, A. Johnson, S.D., Roy, M., Moore, M.E., Moy, C., Loredo, Mehta, R.G., Vaughan, A.T.M. and Ghosh, P.M. Androgen Receptor regulation of Vitamin D receptor in response of castration-resistant prostate cancer cells to 1α-Hydroxyvitamin D5 – a calcitriol analog. Genes and Cancer, 2010. Nov 16;1(9):927-940.
 

Chen, H., Libertini, S.J., George, M., Dandekar, S., Tepper, C.G., Al-Bataina, B., Kung, H.-J., Ghosh, P.M., Mudryj, M. Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines. Endocrine-related cancers. 2010. Oct 5;17(4):857-73.
 

Khan, IH, Zhao, J, Ghosh, PM, Ziman, M, Sweeney, C, Kung, HJ and Luciw, PA. Activation and Dimerization of Receptor Tyrosine Kinases (ErbB Family) in Breast Cancer Cells Analyzed by Multiplex Microbead Suspension Array. ASSAY and Drug Development Technologies. Feb;8(1):27-36. 2010
 

Ghosh P, Qiu Y, Wang LY and Kung HJ. Tyrosine Kinome Profiling: Oncogenic Mutations and Therapeutic Targeting in Cancer ** IN PRESS ** 2010.
 

Bedolla, RG, Asuncion, A, Chamie, K, Siddiqui, S, Troyer, DA, Mehra, R, Siddiqui, J, Chinnaiyan, AM, deVereWhite, RW, and Ghosh, PM. Nuclear vs Cytoplasmic localization of Filamin A in Prostate Cancer: Immunohistochemical Correlation with Metastases. Clinical Cancer Research, 15(3): 788-796. 2009.
 

Chamie, K, Ghosh, PM, Koppie, TM, Romero, V, Troppmann, C,and deVere White, RW. The effect of sirolimus on PSA kinetics in male renal transplant recipients without prostate cancer. American Journal of Transplantation, 8(12): 2668-2673. 2008.
 

Wang, Y, Mikhailova, M, deVere White, RW, and Ghosh, PM. Regulation of androgen receptor transcriptional activity by rapamycin. Oncogene, 27(56): 7106-7117. 2008
 

Kamat, A., Ghosh, PM, Glover, RL, Zhu, B, Yeh, CK, Choudhury, GG and Katz, MS. Reduced Expression of Epidermal Growth Factor Receptors in. Journal of Gerontology, 63(7): 683-692. 2008
 

Mikhailova, M., Wang, Y., Bedolla, R.G., Lu, X.H., Kreisberg, J.I. and Ghosh, P.M.: AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer, Adv Exp Med Biol., Vol. 617, pp. 397-405. 2008.
 

Wang, Y., Kreisberg, J.I. and Ghosh, P.M. Cross-talk between the Androgen Receptor and the Phosphatidylinositol 3-kinase/Akt pathway in Androgen-Independent Prostate Cancer. Current Cancer Drug Targets. 7: 591-604. 2007
 

Shi, X.-B., Xue, L. Tepper, C.G., Gandour-Edwards, R., Ghosh, P., Kung, H.J. and deVere White, R.W. . The oncogenic potential of a prostate cancer-derived androgen receptor mutant. The Prostate, 67(6): 591-602. 2007.
 

Bedolla R, Prihoda TJ, Kreisberg JI, Malik SN, Krishnegowda NK, Troyer DA, Ghosh PM. Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin. Cancer Res., 13(13): 3860-3867. 2007
 

Wang, Y., Kreisberg, J.I., Bedolla, R., Mikhailova, M., deVere White, R.W. and Ghosh, P.M. A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene. 2007.
 

Margarita Mikhailova, Yu Wang, Roble Bedolla, Xiao-Hua Lu, Jeffrey I. Kreisberg, and Paramita M. Ghosh : AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer, Jonathan Li, (ed), Hormonal Carcinogenesis, Vol. 5, Springer Verlag, New York. 2007.
 

Vinall, R.L., Hwa, K., Ghosh, P., Pan, C-X., Lara, P.N. Jr. and deVere White, R.W. Combination Treatment Of Prostate Cancer Cell Lines With Bioactive Soy Isoflavones (GCP) And Perifosine Causes Increased Growth Arrest And/Or Apoptosis. Clinical Cancer Research. 13: 6204-6216. 2007.
 

Wang, Y., Kreisberg, J.I. and Ghosh, P.M. Cross-talk between the Androgen Receptor and the Phosphatidylinositol 3-kinase/Akt pathway in Androgen-Independent Prostate Cancer. Current Cancer Drug Targets. 7: 591-604. 2007
 

Vinall, R.L., Hwa, K., Ghosh, P., Pan, C-X., Lara, P.N. Jr. and deVere White, R.W. Combination Treatment Of Prostate Cancer Cell Lines With Bioactive Soy Isoflavones (GCP) And Perifosine Causes Increased Growth Arrest And/Or Apoptosis. Clinical Cancer Res., 13: 6204-6216, 2007
 

Ghosh, P.M., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Wang, Y., Troyer, D.A. and Kreisberg, J.I. Akt mediates proliferation via both androgen-dependent and independent pathways in prostate cancer. Endocr Relat Cancer. Mar;12(1):119 34. 2005
 

Yeh, C. K.**, Ghosh, P.M.**, Liu, Q., Zhang, B. X., and Katz, M.S. Activation of Mitogen-activated Protein Kinase Mediates Isoproterenol-induced Salivary Cell Growth. Am J Physiol Cell Physiol. 288(6):C1357-C1366. 2005
 

Ghosh, P.M., Bedolla, R., Thomas, C.A. and Kreisberg, JI. Role of Protein kinase C in Arginine Vasopressin-stimulated mesangial cell proliferation. J. Cell. Biochem., 2004; 91(6):1109-29.
 

Kreisberg, J.I., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Troyer, D.A. Kreisberg, S. and Ghosh, P.M. Expression of phospho-AKT (Ser 473) is an excellent predictor of Poor Clinical Outcome in Prostate Cancer. Cancer Res. Aug 1;64(15):5232-6. 2004
 

Ghosh, P.M., Malik, S. N., Bedolla, R. and Kreisberg, J.I. Akt in Prostate Cancer: Possible Role in Androgen-Independence. Current Drug Metabolism, 4(6):487-496. 2003
 

Ghosh PM, Bedolla R, Mikhailova M, and Kreisberg JI. RhoA-Dependent Murine Prostate Cancer Cell Proliferation and Apoptosis: Role of PKCzeta. Cancer Res. 62(9):2630-6. 2002
 

Malik, S.N., Brattain, M.G., Ghosh, P.M., Troyer, D.A., Prihoda, T., Bedolla, R. and Kreisberg, J.I. Immunohistochemical Demonstration of phospho-Akt in High Gleason Grade Prostate Cancer. Clinical Cancer Res. 8(4):1168-71. 2002
 

Sawhney RS, Guo-Hao K, Humphrey LE, Ghosh P, Kreisberg JI, Brattain MG: Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands. J Biol Chem 277: 75-86. 2002
 

Ghosh, P.M., Mikhailova, M., Bedolla, R. and Kreisberg, J.I. Arginine Vasopressin Stimulates Mesangial Cell Proliferation by Activating the Epidermal Growth Factor Receptor. Am. J. Physiol- Renal Physiology. 280(6):F972-979. 2001
 

Ghosh-Choudhury, N., Ghosh-Choudhury, G., Celeste, A., Ghosh, P.M., Moyer, M.L., Abboud, S.L., and Kreisberg, J.I. Bone Morphogenic Protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol treated MCF- human breast cancer cells. Biochim. Biophys. Acta 1497:186-196. 2000
 

Ghosh, P.M., M. Moyer and J.I. Kreisberg. Effect of cyclin E overexpression on lovastatin-induced G1 arrest and RhoA inactivation in NIH3T3 cells. J. Cell. Biochem. 74: 532  543. 1999
 

Ghosh, P.M., G.E. Mott, M.L. Stapleton, N. Ghosh-Choudhury and J.I. Kreisberg. Role of RhoA and actin stress fiber formation in the proliferation of a mouse prostate cancer cell line. Oncogene. 18: 4120-4130. 1999
 

Ghosh, P., G.E. Mott, N. Ghosh-Choudhury, R.A. Radnik, M.L. Stapleton, J.J. Ghidoni and J.I. Kreisberg. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. Biochim. Biophys. Acta. 1359: 13-24. 1997
 

Klebe, R.J., A. Grant, G. Grant and P. Ghosh. 1995. Cyclic-AMP deficient MDCK cells from tubules. J. Cell Biochem. 59:453-462. 1995
 

Klebe, R.J., C.A. Thomas, G.M. Grant, A. Grant and P. Ghosh. Cytoscription: Computer-controlled micropositioning of cell adhesion proteins. J. Tissue Culture Methods. 16:189-192. 1994
 

Ghosh, P.M., C.R. Keese and I. Giaever. Morphological response of mammalian cells to pulsed AC fields. Bioelectrochem. Bioenerg. 33:121-133. 1994
 

Ghosh, P.M., C.R. Keese and I. Giaever. Monitoring Electropermeabilization in the Plasma Membrane of Adherent Mammalian Cells. Biophys. J. 64: 1602-1609. 1993
 

Mitra, P., C.R. Keese and I. Giaever. Electrical Measurements can be used to Monitor the Attachment and Spreading of Cells in Tissue Culture. Biotechniques. 11: 504-510. 1991
 


Laboratory Personnel:

Postdoctoral Fellows
http://www.ucdmc.ucdavis.edu/urology/research/example/example_ghosh.html
Salma Siddiqui; Sheetal Singh

Graduate Students

Rosalinda Savoy; Leandro D'Abronzo; Maitreyee Jathal

Research Associate

Benjamin Mooso; Ryan Beggs; Mohana Roy



Teaching Interests:

Cell and Molecular Biology Biochemistry

Courses:

BCM 410B Cell Biology and Metabolism Winter
BCM 410A Molecular and Cell Biology Fall
MCB 257 Cell Prolif Cancer Genes Fall