Frank R Sharp
Professor
frsharp@ucdavis.edu; frank.sharp@ucdmc.ucdavis.edu

Neurology - Medicine
MIND Institute - UCD Medical Center

Office
MIND BLDG 2805 50th St/UCDMC
+1 916 703 0368


Picture of Frank Sharp
 
Degrees:
1972 MD University of California at San Diego Medicine
1968 BS University of California at Davis Engineering
Research Interests:

Professor of Neurology
Awards:
Resident Teaching Awards UCSD, UCSF, University of Cincinnati
Department and Center Affiliations:
MIND Research Faculty
Department of Neurology
Professional Societies:
American Academy of Neurology
American Neurological Association
Society for Cerebral Blood Flow and Metabolism
Cell Stress and Chaperones Society
Society for Neurosciences
CBS Graduate Group Affiliations:
Genetics  
Neuroscience  
Publications:
  • Kennedy C, DesRosiers M, Reivich M, Jehle J, Sharp FR, Sokoloff L (1975) Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)-deoxyglucose. Science 187: 850-853.
  • Schwartz WJ, Sharp FR, Gunn RH, Evarts EV (1976) Lesions of ascending dopaminergic pathways decrease forebrain glucose uptake. Nature 261: 155-157.
  • Kilduff TS, Sharp FR, Heller HC (1982) 14C 2-deoxyglucose uptake in ground squirrel brain during hibernation. Journal of Neuroscience 2: 143-157.
  • Sagar SM, Sharp FR, Curran T (1988) Expression of c-fos protein in brain: Metabolic mapping at the cellular level. Science 240: 1328-1331.
  • Aronin N, Sagar SM, Sharp FR, Schwartz WJ (1990) Light regulates Fos expression in the suprachiasmatic nuclei. Proceedings of the National Academy of Sciences 87: 5959-5962.
  • Sharp FR, Sagar SM, Marsh T, Hicks K, Lowenstein DH, and Hisanga K (1991) c-fos mRNA, Fos and Fos-related antigen induction by hypertonic saline and stress, Journal of Neuroscience, 11:2321-2331.
  • Sharp FR, Jasper P, Hall J, Noble L, Sagar SM (1991) MK801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex, Annals of Neurology, 30: 801-809.
  • Liu J, Nickolenko J, Sharp FR (1994) Morphine induction of c-fos and junB in striatum and nucleus accumbens is mediated by D1 and NMDA receptors. Proceedings National Academy of Sciences, 91: 8537-8541.
  • Bontempi B, Sharp FR (1997) Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by m1 opioid receptors in the substantia nigra and ventral tegmental area and requires D1 and NMDA receptor co-activation, Journal of Neuroscience 17 (21): 8596-8612.
  • Liu J, Solway K, Messing RO, Sharp FR.(1998) Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. Journal of Neuroscience, 18: 7768-7778.
  • Rajdev S, Hiroshi Y, Hara K, Weinstein P, Mestril R, Dillmann W, Sharp FR (2000) Mice that over express rat heat shock protein70 (HSP70) are protected against cerebral infarction, Annals of Neurology, 47 (6): 782-791.
  • Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR (2000) Hypoxia-inducible factor-1 (HIF-1) role in hypoxia-induced ischemic tolerance in neonatal rat brain, Annals of Neurology, 48(3): 285-296.
  • Sharp FR, Tomitaka M, Bernaudin M, Tomitaka S (2001) Psychosis: Pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia? Trends in Neurosciences, June, 24 (6): 330-334.
  • Clark JF, Reilly MR, Sharp FR (2002) Oxidation of bilirubin produces compounds that cause prolonged vasospasm of rat cerebral vessels: Contributor to subarachnoid hemorrhage induced vasospasm, Journal of Cerebral Blood Flow and Metabolism, 22(4):472-478
  • Bernaudin M, Tang Y, Reilly MR, Petit E, Sharp FR (2002) Brain genomic response following hypoxia and re-oxygenation in the neonatal rat: Identification of genes that might contribute to hypoxia-induced ischemic tolerance, Journal of Biological Chemistry, Oct 18; 277 (42):39728-39738.
  • Ran R, Zhou G, Lu A, Tang Y, Rigby AC, Vaux DL, and Sharp FR (2004) Hsp70 impairs NF-kB signaling and promotes TNF-alpha-mediated apoptosis, Genes and Development, 18 (12) 1466-1481
  • Ran R, Zhou G, Lu A, Zhang L, Tang Y, Rigby AC, Sharp FR. (2004) Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival. Cell Stress Chaperones. Autumn;9(3):229-242
  • Tang Y, Schapiro MB, Franz DN, Patterson BJ, Hickey FJ, Schorry EK, Hopkin RJ, Wylie M, Narayan T, Glauser TA, Gilbert DL, Hershey AD, Sharp FR . Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and down's syndrome. Annals of Neurology 2004 Dec;56(6):808-14
  • Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, Sharp FR, Rakic P (2004) Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. Journal of Neurosscience Nov ;24(47):10763-10772
  • Sharp FR and Bernaudin M (2004) HIF1 and oxygen sensing in the brain. Nature Review Neuroscience 5(6):437-448
  • Tang Y, Lu A, Ran R, Aronow BJ, Schorry EK, Hopkin RJ, Gilbert DL, Glauser TA, Hershey AD, Richtand NW, Privitera M, Dalvi A, Sahay A, Szaflarski JP, Ficker DM, Ratner N, Sharp FR (2004). Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Molecular Brain Research 132(2):155-167
Laboratory Personnel:
MIND Molecular and Genomics Biology Laboratory 2805 50th St

Ruiqiong Ran MD PhD; Xinshe Liu MD PhD; Lisa Lit, graduate student; Huichun Xu, graduate student; Wynn Walker Project Scientist; Xinjua Zhan Project Scientist

Teaching Interests:
Molecular Biology of Brain Injury, Genomics, Neurology
Courses:
Neu Molecular Neurobiology Journal Club Fall,Winter,Spring