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Cecilia Giulivi

Professor
cgiulivi@ucdavis.edu


VM Molecular Biosciences

Office
1095 HARING HALL
+1 530 754 8603

Lab
2116 Haring Hall
530-752-1038

Lab
2116 Haring Hall




Degrees:

1989 PhD University of Buenos Aires Biochemistry
1985 Diploma University of Buenos Aires Biochemistry

Department and Center Affiliations:

Molecular Biosciences, School of Veterinary Medicine; Member of the UC Davis Cancer Center

Professional Societies:

American Society for Biochemistry and Molecular Biology
Society for Free Radical Research

CBS Graduate Group Affiliations:

Biochemistry, Molecular, Cellular and Developmental Biology  

Specialties / Focus:

Biochemistry, Molecular, Cellular and Developmental Biology
Genomics, Proteomics and Metabolomics
Metabolism and Molecular Physiology
Molecular Medicine

Publications:

Last updated 1/27/2011
Villanueva C, Giulivi C. Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease. Free radical biology & medicine. 2010;49(3):307-16. PMCID: 2900489.
 

Ross-Inta, C., Tsai, C.-Y., and Giulivi, C. (2008) The mitochondrial pool of free amino acids reflects the composition of mitochondrial-DNA encoded proteins: Indication for a post-translational quality control for protein synthesis. Biosci. Reports 28, 239-49.
 

Giulivi, C., Ross-Inta, C.M., Horton, A., and Luckhart, S. (2008) Metabolic Pathways in Anopheles stephensi mitochondria. Biochem. J. 415, 309-16.
 

DiMarco, T. and Giulivi, C. (2007) Evaluation of analytical methods to detect dityrosine, a biomarker of oxidative stress, in biological samples. Mass Spec. Rev. 26, 108-120.
 

Miller, S., Inta-Ross, C. and Giulivi, C. (2007) Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase: consequences for cancer energy metabolism. Amino acids 32, 593-602.
 

Cooper CE and Giulivi, C. (2007) Nitric oxide regulation of mitochondrial oxygen consumption II: molecular mechanism and tissue physiology. Am J Physiol. 292, 1993-2003.
 

Giulivi, C., Kato, K. And Cooper, C. E. (2006) Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology. Am. J. Physiol. 291, 1225-1231.
 

Kato K, Giulivi C. (2006) Critical overview of mitochondrial nitric-oxide synthase. Front Biosci. 11:2725-38.
 

Mazzanti, R. and Giulivi, C. (2006) Coordination of nuclear- and mitochondrial-DNA encoded proteins in cancer and normal colon tissues. Biochim Biophys Acta 1757, 618-623.
 

Mazzanti, R., Solazzo, M. Squires, R., Fantappie, O., Cechi, F, Bianchi, P., and Giulivi, C. (2006) Differential expression proteomics of human colon cancer. Am J Physiol 290:G1329-38.
 

Green, A., Rutherford, M. S., Regal, R. R., Flickinger, G. H., Hendrickson, J. A., Giulivi, C., Mohrman, M. E., Fraser, D. G., and Regal, J. F. (2005) Arginase Activity Differs with Allergen in the Effector Phase of Ovalbumin- versus Trimellitic Anhydride-Induced Asthma. Tox. Sci. 88, 420-433.
 

Johnson F, Giulivi C. (2005) Superoxide dismutases and their impact upon human health. Mol Aspects Med. 26, 340-352.
 

Oursler, M. J., Bradley, E., Elfering, S. and Giulivi, C. (2005) Native, not nitrated, cytochrome c and mitochondrial-derived hydrogen peroxide drive osteoclast apoptosis. Am., J. Physiol. 288, C156-168.
 

Haynes, V., Elfering, S. L., Squires, R., Traaseth, N., Solien, J., Ettl , A. and Giulivi, C. (2004) Mitochondrial Nitric-Oxide Synthase: Role in Pathophysiology. IUBMB Life 55, 599-603.
 

Traaseth, N, Elfering, S. L., Solien, J., Haynes, V., and Giulivi, C. (2004) Role of Calcium Signaling in the Activation of Mitochondrial Nitric-Oxide Synthase and Citric Acid Cycle. Biochim. Biophys. Acta 1658, 64-71.
 

Haynes, V., Elfering, S. L., Traaseth, N., and Giulivi, C. (2004) Mitochondrial Nitric-Oxide Synthase: Enzyme expression, characterization and regulation. J. Bioenerg. Biomemb. 36, 341-346.
 

Elfering, S. L., Haynes, V., Traaseth, N., Ettl, A. and Giulivi, C. (2004) Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthase. Am. J. Physiol. 286, H22-H29.
 

Xiong, S., She, H., Takeuchi, H., Engelhardt, J. F., Barton, C. H., Zandi, E., Giulivi, C., and Tsukamoto, H. (2003) Signaling role of intracellular iron in NF-kB activation. J. Biol. Chem. 278, 17646-54.
 

Giulivi, C. (2003) Characterization and function of mitochondrial nitric-oxide synthase. Free Radical Biol. Med. 34, 397-408.
 

Giulivi, C, Traaseth, N. J., and Davies, K. J. A. (2003) Tyrosine oxidation products: analysis and biological relevance. Amino Acids 25, 227-232.
 

Elfering, S. L., Sarkela, T. M. and Giulivi, C. (2002) Biochemistry of mitochondrial nitric oxide synthase. J. Biol. Chem. 277, 38079-38086.
 

Sarkela, T., Berthiaume, J., Elfering, S., Gybina, A. and Giulivi, C. (2001) The modulation of oxygen radical production by endogenous nitric oxide in mitochondria. J. Biol. Chem. 276, 6945-6949.
 

Steffen, M., Sarkela, T.M., Gybina, A.A., Steele, T.W., Traaseth, N. J., Kuehl, D. and Giulivi, C. (2001) Metabolism of S-nitrosoglutathione in intact mitochondria. Biochem. J. 356, 395-402.
 

French, S., Giulivi, C., and Balaban, R. S. (2001) Nitric oxide synthase in porcine heart mitochondria: Evidence for a low physiological activity. Am. J. Physiol. 280, H2863-7.
 

Lizarralde MS, Bailliet G, Poljak S, Fasanella M, Giulivi C. Assessing genetic variation and population structure of invasive North American beaver (Castor Canadensis Kuhl, 1820) in Tierra Del Fuego (Argentina). Biological Invasions. 2008;10(5):673-83.
 

Fujisawa Y, Kato K, Giulivi C. Nitration of tyrosine residues 368 and 345 in the beta -subunit elicits F0F1-ATPase activity loss. Biochem J. 2009;423(2):219-31.
 

Ross-Inta CM, Zhang YF, Almendares A, Giulivi C. Threonine-deficient diets induced changes in hepatic bioenergetics. American journal of physiology. 2009;296(5):G1130-9. PMCID: 2696218.
 

Giulivi C, Zhang Y-F, Omanska-Klusek A, Ross-Inta CM, Wong S, Hertz-Picciotto I, et al. Mitochondrial dysfunction in autism. JAMA. 2010;304:2389-96.
 

Haynes V, Traaseth NJ, Elfering S, Fujisawa Y, Giulivi C. Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging. Am J Physiol Endocrinol Metab. 2010;298(5):E978-87. PMCID: 2867368.
 

Perez CJ, Jaubert J, Guenet J-L, Barnhart KF, Ross-Inta CM, Quintanilla VC, et al. Two Hypomorphic Alleles of Mouse Ass1 as a New Animal Model of Citrullinemia Type I and Other Hyperammonemic Syndromes. American Journal of Pathology. 2010;177(4):1958-68.
 

Ross-Inta C, Omanska-Klusek A, Wong S, Barrow C, Garcia-Arocena D, Iwahashi C, et al. Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome. The Biochemical journal. 2010;429(3):545-52.
 

Giulivi C, Ross-Inta C, Omanska-Klusek A, Napoli E, Sakaguchi D, Barrientos G, et al. Basal Bioenergetic Abnormalities in Skeletal Muscle from Ryanodine Receptor Malignant Hyperthermia-susceptible R163C Knock-in Mice. Journal of Biological Chemistry. 2011;286(1):99-113.
 


Laboratory Personnel:

Giulivi's laboratory

Drs. Eleonora Napoli, Marco Calafiore, Lakmal Kotewala. Ms. Sarah Wong and Ms. Danielle Sakaguchi.



Teaching Interests:

Biological Chemistry; Spectroscopy; Bioenergetics; Oxygen and nitrogen free radical biochemistry.

Courses:

PTX 290 Seminar Spring
VM 403 Physiological Chemistry Fall

Key Words:

Mitochondria, autism, Huntington's disease, fragile X, tremor and ataxia, oxidative and nitrative stress, intermediary metabolism