Heike Wulff
Asst Professor
hwulff@ucdavis.edu

Pharmacology - Medicine

Office
1440 TUPPER HALL
+1 530 754 6135



 
Degrees:
1998 PhD University of Kiel, Germany Medicinal Chemistry
Department and Center Affiliations:
Medical Pharmacology and Toxicology, School of Medicine
Professional Societies:
American Chemical Society
Biophysical Society
CBS Graduate Group Affiliations:
Biophysics  
Molecular, Cellular, and Integrative Physiology  
Graduate Groups not Housed in CBS:
Pharmacology and Toxicology (PTX)  
Publications:
  • Wulff H., Rauer H., D?ring T., Hanselmann C., Ruff K., Wrisch A., Grissmer S., H?nsel W. (1998). Alkoxypsoralens: Novel Nonpeptide Blockers of Shaker-type K+ Channels: Synthesis and Photoreactivity. Journal of Medicinal Chemistry 41: 4542-4549.
  • Strauss U., Wissel, K., Jung, S., Wulff H., H?nsel W., Zhu, J., Rolfs A., Mix E. (2000). K+ channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for autoimmune encephalomyelitis. Immunopharmacology 48: 51-63.
  • Wulff H., Miller, M.J., H?nsel W., Grissmer, S., Cahalan, M.D., Chandy, K.G. (2000). Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant. Proceedings of the National Academy of Sciences 97: 8151-8156.
  • Ghanshani S., Wulff H., Miller M. J., Rohm H., Neben, A., Gutman G.A., Cahalan M.D., Chandy, K.G (2000). Up-regulation of the IKCa1 potassium channel during T-cell activation: Molecular mechanism and functional consequences. Journal of Biological Chemistry 275: 31137-37149.
  • Fanger C.M., Rauer H, Neben A.L., Miller M.J., Rauer H., Wulff H., Campos-Rosa J., Ganellin C.R., Chandy K.G., Cahalan M.D. (2001). Calcium-activated potassium channels sustain calcium signaling in T lymphocytes: Selective blockers and manipulated channel expression levels. Journal of Biological Chemistry 276: 2249-12256.
  • D?ring T., Gerst F., H?nsel W., Wulff H., Koppenh?fer E. (2000). Effects of three alkoxypsoralens on voltage-gated potassium channels in Ranvier Nodes. Gen. Physiol. Biophys. 19: 345-364.
  • Hinck D., Wulff H., Koppenh?fer E. (2001). Gallamine triethiodide selectively blocks volatge-gated potassium channels in Ranvier Nodes. Gen. Physiol. Biophys. 20: 83-95.
  • Wulff H., Gutman G.A., Cahalan M.D., Chandy K.G. (2001) Delineation of the clotrimazole/TRAM-34 binding site on the intermediate-conductance calcium-activated potassium channel, IKCa1. Journal of Biological Chemistry 276: 32040-32045. Beeton C.*, Wulff H.* (*joint first authors), Barbaria J., Clot-Faybesse O., Pennington M., Bernard D., Cahalan M.D., Chandy K.G., B?raud E. (2001). Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proceedings of the National Academy of Sciences USA 98: 13942-13947.
  • Shakkotai V.G., Regaya I., Wulff H., Fajloun Z., Tomita H., Fathallah M., Cahalan M., Gargus J.J., Sabatier J.-M., Chandy K.G. (2001). Design and characterization of a higly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SKCa2. In press: Journal of Biological Chemistry 276: 43145-43151.
  • Ayabe T., Wulff H., Darmoul D., Cahalan M.D., Chandy K.G., Ouellette A.J. (2002) Modulation of Mouse Paneth Cell a-Defensin Secretion by mIKCa1, a Ca2+-activated, Intermediate-Conductance Potassium Channel. Journal of Biological Chemistry 277: 3793-3800.
  • Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V. (2002) Characterization of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). European Journal of Human Genetics 10: 36-43.
  • Beeton C., Wulff H., Singh S., Botsko S., Crossley G., Gutamn G.A., Cahalan, M.D., Pennington M., Chandy K.G. (2002) A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. Journal of Biological Chemistry 278: 9928-9937.
  • Wulff H., Calabresi P.A., Allie R., Yun S., Pennington M., Beeton C., Chandy K.G. (2003) The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS. Journal of Clinical Investigation 111: 1703-1713.
  • Kohler R., Wulff H., Eichler I., Kneifel M., Neumann D., Knorr A., Grgic I., Brakemeier S., Orzechowski H.-D., Reusch P.H., Chandy K.G., Hoyer J. (2003) Blockade of the IKCa1 Ca2+-activated K+ channel as a new therapeutic strategy for restenosis. Circulation 108: 119-1125.
  • Mouhat S., Mosbah A., Visan V., Wulff H., Delepierre M., Darbon H., Grissmer S., De Waard M., Sabatier J.M. (2004) The "functional" dyad of scorpion toxin Pi1 is not per se a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochemical Journal 377::25-36.
  • Baell J.B., Gable R.W., Harvey A.J., Toovey N., Herzog T., H?nsel W., Wulff H. (2004) Kellinone derivatives as Blocekrs of the voltage-gated potassium channel Kv1.3: Synthesis and Immunosuppressive Activity. Journal of Medicinal Chemistry. In press.
  • Vennekamp J.*, Wulff H.* (*joint first authors), Beeton C., Calabresi P.A., Grissmer S., H?nsel W., Chandy K.G. (2004) Kv1.3 blocking 5-Phenylalkoxypsoralens: A new class of immunomodultors. Molecular Pharmacology. In press.
  • Wulff H., Koppenh?fer E., H?nsel W. (1998). Potassium Channel Blocking Psoralens, Benzofurans, Acridones and Coumarins for the Treatment of Multiple Sclerosis and Related Diseases. Current Research in Ion Channel Modulators 3: 207-212.
  • Chandy K. G., Cahalan M. D., Pennington M., Norton R. S., Wulff H., Gutman G.A. (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39: 1269-1276.
  • Cahalan M. D., Wulff H., Chandy K.G. (2001). Molecular properties and physiological roles of ion channels in the immune system. Journal of Clinical Immunology 21: 235-252.
  • Wulff H., Beeton C., Chandy K.G. (2003) Potassium channels as therapeutic targets for autoimmune disorders. Current Opinion in Drug Discovery & Development 6:640-647.
  • Gutman G.A., Chandy K.G., Adelman J.P., Aiyar J., Bayliss D.A., Clapham D.E., Covarriubias M., Desir G.V., Furuichi K., Ganetzky B., Garcia M.L., Grissmer S., Jan L.Y., Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D., Nichols C.G., O'Kelly I., Robbins J., Robertson G.A., Rudy B., Sanguinetti M., Seino S., Stuehmer W., Tamkun M.M., Vandenberg C.A., Wei A., Wulff H., Wymore R.S. (2003) International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium channels. Pharmacological Reviews 55:583-586.
  • Chandy K.G., Wulff H., Beeton C., Pennington M., Gutman G.A., Cahalan M.D. Potassium Channels as Targets for Specific Immunomodulation. Trends in Pharmacological Sciences. In press.