Alan Rose
Associate Project Scientist
abrose@ucdavis.edu
Molecular & Cellular Biology
Office
126 Briggs Hall
(530)754-9892
Degrees:
0
BS
University of Waterloo
Biology
0
MS
York University
Molecular Biology
0
PhD
Princeton University
Molecular Biology
Research Contribution to Society:
Understanding how gene expression works is important as basic science, and has numerous practical applications in biotechnology.
Research Interests:
The effect of introns on gene expression.
Introns are often dismissed as junk DNA, but they can have huge effects on gene expression through mechanisms that are not yet understood. I am investigating this interesting phenomenon in plants using molecular genetics, and by testing bioinformatic insights generated by Dr. Ian Korf and his group.
Department and Center Affiliations:
Molecular and Cellular Biology
CBS Graduate Group Affiliations:
Genetics
Plant Biology
Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus:
Biochemistry, Molecular, Cellular and Developmental Biology
Plant Biochemistry and Molecular Biology
Genetics
Model Plants
Plant Biology
Molecular Biology, Biochemistry, and Genomics
Publications:
Last updated 1/19/2012
Rose, A.B., S. Emami, K. Bradnam, and I Korf (2011). Evidence for a DNA-based mechanism of intron-mediated enhancement. Frontiers in Plant Science 2:98.
Parra, G., K. Bradnam, A. Rose, and I. Korf (2011). Comparative and functional analysis of intron-mediated enhancement signals reveals conserved features among plants. Nucleic Acids Research 39:5328-5337.
Rose, A.B., T. Elfersi, G. Parra, and I. Korf (2008) Promoter-Proximal Introns in Arabidopsis thaliana are Enriched in Dispersed Signals that Elevate Gene Expression. Plant Cell 20:543-551.
Rose, A.B. (2008). Intron-mediated regulation of gene expression. In Nuclear pre-mRNA Processing in Plants (A.S.N. Reddy and M. Golovkin, eds.) Springer-Verlag, New York. Current Topics in Microbiology and Immunology 326:277-290.
Rose, A.B. (2007) Book Review: Plant Gene Expression. Science STKE, pe26.
Belostotsky, D.A. and A.B. Rose (2005). Plant gene expression in the age of systems biology: Integrating transcriptional and post-transcriptional events. Trends in Plant Science 10:347-353.
Rose, A.B. (2004). The effect of intron location on intron-mediated enhancement of gene expression in Arabidopsis. Plant Journal 40:744-751.
Rose, A.B. (2002). Requirements for intron-mediated enhancement of gene expression in Arabidopsis. RNA. 8:1444-1453.
Shibagaki, N., A. Rose, J.P. McDermott, T. Fujiwara, H. Hayashi, T. Yoneyama, and J.P. Davies (2002). Selenate-resistant mutants of Arabidopsis thaliana identify Sultr1;2, a sulfate transporter required for efficient transport of sulfate into roots. Plant Journal 22:475-486.
Rose, A.B. and J.A. Beliakoff (2000). Intron-mediated enhancement of gene expression independent of unique intron sequences and splicing. Plant Physiology, 122:535-542.
Rose, A.B. and R.L. Last (1997). Introns act post-transcriptionally to increase expression of the Arabidopsis thaliana tryptophan pathway gene PAT1. Plant Journal 11:455-464.
Rose, A.B., J. Li, and R.L. Last (1997). An Allelic Series of Blue Fluorescent trp1 Mutants of Arabidopsis thaliana. Genetics 145:197-205.
Li, J., J. Zhao, A.B. Rose, R. Schmidt, and R.L. Last (1995). Arabidopsis phosphoribosylanthranilate isomerase: Molecular genetic analysis of triplicate tryptophan pathway genes. Plant Cell 7:447-461.
Rose, A.B., A.L. Casselman, and R.L. Last (1992). A phosphoribosylanthranilate transferase gene is defective in blue fluorescent Arabidopsis thaliana tryptophan mutants. Plant Physiology 100:582-592.
Laboratory Personnel:
Alan Rose
25 Briggs Hall
Ian Haydon, Noah Kojima (Undergraduates).
Courses:
PBI
298
Plant Molecular Biology Discussion
MCB
120L
Biochemistry lab
BIS
102
Structure and Function of Macromolecules
Key Words:
Gene expression, Introns, Arabidopsis