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Alan Rose

Associate Project Scientist

126 Briggs Hall


0 BS University of Waterloo Biology
0 MS York University Molecular Biology
0 PhD Princeton University Molecular Biology

Research Contribution to Society:

Understanding how gene expression works is important as basic science, and has numerous practical applications in biotechnology.

Research Interests:

The effect of introns on gene expression.
Introns are often dismissed as junk DNA, but they can have huge effects on gene expression through mechanisms that are not yet understood. I am investigating this interesting phenomenon in plants using molecular genetics, and by testing bioinformatic insights generated by Dr. Ian Korf and his group.

Department and Center Affiliations:

Molecular and Cellular Biology

CBS Graduate Group Affiliations:

Plant Biology  
Biochemistry, Molecular, Cellular and Developmental Biology  

Specialties / Focus:

Biochemistry, Molecular, Cellular and Developmental Biology
Plant Biochemistry and Molecular Biology

Model Plants

Plant Biology
Molecular Biology, Biochemistry, and Genomics


Last updated 1/19/2012
Rose, A.B., S. Emami, K. Bradnam, and I Korf (2011). Evidence for a DNA-based mechanism of intron-mediated enhancement. Frontiers in Plant Science 2:98.

Parra, G., K. Bradnam, A. Rose, and I. Korf (2011). Comparative and functional analysis of intron-mediated enhancement signals reveals conserved features among plants. Nucleic Acids Research 39:5328-5337.

Rose, A.B., T. Elfersi, G. Parra, and I. Korf (2008) Promoter-Proximal Introns in Arabidopsis thaliana are Enriched in Dispersed Signals that Elevate Gene Expression. Plant Cell 20:543-551.

Rose, A.B. (2008). Intron-mediated regulation of gene expression. In Nuclear pre-mRNA Processing in Plants (A.S.N. Reddy and M. Golovkin, eds.) Springer-Verlag, New York. Current Topics in Microbiology and Immunology 326:277-290.

Rose, A.B. (2007) Book Review: Plant Gene Expression. Science STKE, pe26.

Belostotsky, D.A. and A.B. Rose (2005). Plant gene expression in the age of systems biology: Integrating transcriptional and post-transcriptional events. Trends in Plant Science 10:347-353.

Rose, A.B. (2004). The effect of intron location on intron-mediated enhancement of gene expression in Arabidopsis. Plant Journal 40:744-751.

Rose, A.B. (2002). Requirements for intron-mediated enhancement of gene expression in Arabidopsis. RNA. 8:1444-1453.

Shibagaki, N., A. Rose, J.P. McDermott, T. Fujiwara, H. Hayashi, T. Yoneyama, and J.P. Davies (2002). Selenate-resistant mutants of Arabidopsis thaliana identify Sultr1;2, a sulfate transporter required for efficient transport of sulfate into roots. Plant Journal 22:475-486.

Rose, A.B. and J.A. Beliakoff (2000). Intron-mediated enhancement of gene expression independent of unique intron sequences and splicing. Plant Physiology, 122:535-542.

Rose, A.B. and R.L. Last (1997). Introns act post-transcriptionally to increase expression of the Arabidopsis thaliana tryptophan pathway gene PAT1. Plant Journal 11:455-464.

Rose, A.B., J. Li, and R.L. Last (1997). An Allelic Series of Blue Fluorescent trp1 Mutants of Arabidopsis thaliana. Genetics 145:197-205.

Li, J., J. Zhao, A.B. Rose, R. Schmidt, and R.L. Last (1995). Arabidopsis phosphoribosylanthranilate isomerase: Molecular genetic analysis of triplicate tryptophan pathway genes. Plant Cell 7:447-461.

Rose, A.B., A.L. Casselman, and R.L. Last (1992). A phosphoribosylanthranilate transferase gene is defective in blue fluorescent Arabidopsis thaliana tryptophan mutants. Plant Physiology 100:582-592.

Laboratory Personnel:

Alan Rose

25 Briggs Hall

Ian Haydon, Noah Kojima (Undergraduates).


PBI 298 Plant Molecular Biology Discussion
MCB 120L Biochemistry lab
BIS 102 Structure and Function of Macromolecules

Key Words:

Gene expression, Introns, Arabidopsis