John A. Payne
Professor
japayne@ucdavis.edu

Physiology and Membrane Biology

Office
4112A Tupper Hall
(530) 752-3336



 
Degrees:
1991 PhD University of Florida Zoology
1987 MS Duke University Physiology
1983 BA University of California, Berkeley Biology (marine emphasis)
Research Interests:

Ion and water homeostasis of excitable cells
Awards:
Membership, Honor Society of Phi Kappa Phi
Established Investigator, American Heart Association
Department and Center Affiliations:
Center for Neuroscience
Professional Societies:
American Physiological Society
Society for Neuroscience
Biophysical Society
Red Cell Club
CBS Graduate Group Affiliations:
Molecular, Cellular, and Integrative Physiology  
Biochemistry, Molecular, Cellular and Developmental Biology  
Graduate Groups not Housed in CBS:
Pharmacology and Toxicology  
Publications:
  • Payne, J.A. The potassium-chloride cotransporters: from cloning to structure and function. In Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases. (Ed. F.J. Alvarez-Leefmans and E. Delpire). Elsevier, 2009.
  • Chung, C.-Y. and J.A. Payne. Modulaton of GABAergic signaling: role of neuronal chloride. In Encyclopedia of Basic Epilepsy Research, (Ed. P.A. Schwartzkroin). Elsevier, 2009.
  • Lee, H.H.C., J.A. Walker, J.R. Williams, R.J. Goodier, J.A. Payne, and S.J. Moss. Direct PKC-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter, KCC2. J. Biol. Chem. 282: 29777-29784, 2007.
  • Williams, J.R. and J.A. Payne. Cation transport by the neuronal K-Cl cotransporter, KCC2: Thermodynamics and kinetics of alternate transport modes. Am. J. Physiol. Cell Physiol. 287: C919-C931, 2004.
  • Payne, J.A., C. Rivera, J. Voipio, and K. Kaila. Cation chloride cotransporters and their role in neuronal communication, development, and trauma. Trends in Neurosci. 26(4): 199-206, 2003.
  • Gulyas, A.I., A. Sik, J.A. Payne, K. Kaila, and T.F. Freund. High expression of the K-Cl cotransporter, KCC2, in postsynaptic membranes associated with excitatory inputs of the rat hippocampus emphasizes a dual role in ion and water homeostasis. Eur. J. Neurosci. 13: 2205-2217, 2001.
  • Williams, J.R., J.W. Sharp, V.G. Kumari, M. Wilson, and J.A. Payne. The neuron-specific K-Cl cotransporter, KCC2: antibody development and initial characterization of the protein. J. Biol. Chem. 274(18): 12656-12664, 1999.
  • Rivera, C., J. Voipio, J.A. Payne, E. Ruusuvuori, H. Lahtinen, K. Lamsa, U. Pirvola, M. Saarma, K. Kaila. The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397: 251-255, 1999.
  • Payne, J.A. Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation. Am. J. Physiol. (Cell Physiol. 42) 273: C1516-C1525, 1997.
Courses:
MCP 210B Advanced Physiology Winter
HPH 400 Medical Physiology Fall