Anne A. Knowlton
PROF/PROF IN RES-MEDCOMP-A
aaknowlton@ucdavis.edu

Cardiovascular Physio(IntMed)
Pharmacology - Medicine

Office
GBSF 6317
530-752-5461


Picture of Anne Knowlton
 
Degrees:
1979 MD Yale Medicine
1974 BA Harvard University Biology, magna cum laude
Research Interests:

The work in our laboratory focuses on heat shock proteins (HSPs) and their role in disease. Most of our work centers on two areas: 1. Regulation of HSP expression, and investigation of alternative modes of induction of expression. 2. Role of HSP60 in apoptosis and heart failure. In particular, we are interested in whether HSPs in heart failure paradoxically have a detrimental effect on the heart mediated by the immune system and an inflammatory response. Our research concentrates on cardiovascular function/physiology primarily at the cellular and organ level. Our second area of research is estrogen and aging. We are interested in: 1. The role of aging vs. estrogen loss on changes in the vasculature and the acceleration of atherosclerosis with menopause. 2. The effect of aging vs. estrogen loss on endothelial progenitor cells and vascular repair.
Department and Center Affiliations:
Molecular & Cellular Cardiology, Cardiovascular Division, Department of Medicine
Medical Pharmacology
Professional Societies:
International Society for Heart Research
Fellow, American Physiological Society
Fellow, American Heart Association
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology  
Molecular, Cellular, and Integrative Physiology  
Graduate Groups not Housed in CBS:
Pharmacology and Toxicology (PTX)  
Publications: Last updated 11/17/2009
  • Kirchhoff, S.R., S. Gupta, A.A. Knowlton. (2002) Cytosolic HSP60, apoptosis and myocardial injury. Circulation 105:2899-2904.
  • Voss, M, J. Stallone, M. Li, P. Knuefermann, A.A.Knowlton. (2003) Gender Differences in the Expression of Heat Shock Proteins: The Effect of Estrogen. Am. J. Physiol. 285:H687-H692.
  • Gupta,S. and A.A. Knowlton Cytosolic HSP60, Hypoxia, and Apoptosis. (2002) Circulation 106:2727-2733.
  • Hamilton, K., Mbai, F.N., S. Gupta and A.A.Knowlton.(2004) Estrogen, Heat Shock Proteins and NFkB in human vascular endothelium. Atherosclerosis and Vascular Biology 24:1628-1633
  • Voss, M.R., S. Gupta, J.P. Stice, G. Baumgarten, Lu, L. J.M. Tristan and A.A.Knowlton. (2005) Effect of Mutation of Amino Acids 246-251 (KRKHKK) in HSP72 on Protein Synthesis and Recovery from Hypoxic Injury. Am. J. Physiol. 289:H2519-H2525. PMID: 16100242
  • Gupta, S. & A.A. Knowlton.(2007) HSP60 Trafficking in Adult Cardiac Myocytes: Role of the Exosomal Pathway. Am. J. Physiol. 292:H3052-6. PMID: 17307989
  • Lin, L., S.C. Kim, Y. Wang, S. Gupta, B. Davis, S. I. Simon, G. Torre-Amione, and A.A. Knowlton. (2007) HSP60 in Heart Failure: Abnormal Distribution and Role in Cardiac Myocyte Apoptosis. Am. J. Physiol.293:H2238-47. PMID: 17675567
  • Hamilton, K.L., L. Lin, Y. Wang, and A.A.Knowlton.(2008) Effect of Ovariectomy on Cardiac Gene Expression: Inflammation and Changes in SOCS Genes Expression. Physiol. Genomics 32:254-263.PMID: 17986523
  • Stice, J.P., J. Eiserich, and A.A. Knowlton.(2009) Role of Aging vs. Loss of Estrogen in the Reduction in Vascular Function in Female Rats. Endocrinology 150:212-219. PMID: 18787021
  • Chen, L., Q. Gong, J.P. Stice, A.A.Knowlton.(2009) Mitochondrial OPA1, Apoptosis and Heart Failure. Cardiovascular Research 84:91-99.PMID:19493956
  • Kim, S.C., J.P. Stice, L. Chen, J.S. Jung, Y. Wang, S. Gupta, G. Baumgarten, J. Trial and A. A. Knowlton.(2009) Extracellular Heat Shock Protein 60, Cardiac Myocytes and Apoptosis. Circ. Res. in press.
Laboratory Personnel:
Molecular & Cellular Cardiology

Ricky (Le) Chen, Ph.D., postdoc, Angela Pechenino, Ph.D., postdoc, Shuyun Wang, Ph.D., Project Scientist, Kayleen Kott, Ph.D., Project Scientist, Lorie Bischel, Lab Assistant, Naficeh Dastgheyb, undergraduate

Courses:
CLH 230 Molecular Mechanisms of Disease: Congestive Heart Failure Winter
Key Words:
Heat shock proteins, estrogen, aging, immune system, inflammation, endothelial cells, cardiac myocytes, endothelial progenitor cells (EPCs)