Nipavan Chiamvimonvat
Professor
nchiamvimonvat@ucdavis.edu

Cardiovascular Physio(IntMed)

Office
GBSF 6315
530-754-7158



 
Degrees:
1984 MD University of Toronto Medicine
1980 Faculty of Arts & Science, University of Toronto Science
Research Interests:

The study of the functional roles of different isoforms of cardiac calcium channels using combined techniques of transgenic mouse models, gene silencing and patch-clamp recordings.
Awards:
Program Director, National Institutes of Health T32 Training Program in Basic and Translational Cardiovascular Sciences
Co-Director, HHMI Integrating Medicine into Basic Science Training Program
Department and Center Affiliations:
Department of Internal Medicine, School of Medicine
Professional Societies:
Society of General Physiologists, Biophysical Society, Council on Basic Cardiovascular Sciences, American Heart Association
CBS Graduate Group Affiliations:
Molecular, Cellular, and Integrative Physiology  
Graduate Groups not Housed in CBS:
Pharmacology and Toxicology  
Publications:
  • Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A. 2009. In press.
  • Li N, Timofeyev V, Tuteja D, Xu D, Lu L, Zhang Q, Zhang Z, Singapuri A, Albert T, Rajagopal A, Bond CT, Periasamy M, Adelman J, Chiamvimonvat N. Ablation of a Ca-activated K channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol. 2009. In press.
  • Chen CY, Chow D, Chiamvimonvat N, Glatter KA, Li N, He Y, Pinkerton KE, Bonham AC. Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice. Am J Physiol Heart Circ Physiol. 2008;295(2):H632-639.
  • Zhang Q, Timofeyev V, Lu L, Li N, Singapuri A, Long MK, Bond CT, Adelman JP, Chiamvimonvat N. Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes. Circ Res. 2008;102(4):465-471.
  • Harris TR, Li N, Chiamvimonvat N, Hammock BD. The potential of soluble epoxide hydrolase inhibition in the treatment of cardiac hypertrophy. Congest Heart Fail. 2008;14(4):219-224.
  • Chiamvimonvat N, Ho CM, Tsai HJ, Hammock BD. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol. 2007;50(3):225-237.
  • Lu L, Zhang Q, Timofeyev V, Zhang Z, Young JN, Shin HS, Knowlton AA, Chiamvimonvat N. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007;100(1):112-120
  • Xu Y, Zhang Q, Chiamvimonvat N. IK1 and cardiac hypoxia: after the long and short QT syndromes, what else can go wrong with the inward rectifier K+ currents? J Mol Cell Cardiol. 2007;43(1):15-17.
  • Glatter KA, Hamdan MH, Zhang Q, Chiamvimonvat N. Drug-induced long QT syndrome: a continuing challenge in the field. J Cardiovasc Electrophysiol. 2007;18(7):696-697.
  • Dirksen WP, Lacombe VA, Chi M, Kalyanasundaram A, Viatchenko-Karpinski S, Terentyev D, Zhou Z, Vedamoorthyrao S, Li N, Chiamvimonvat N, Carnes CA, Franzini-Armstrong C, Gyorke S, Periasamy M. A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice. Cardiovasc Res. 2007;75(1):69-78.
  • Babu GJ, Bhupathy P, Timofeyev V, Petrashevskaya NN, Reiser PJ, Chiamvimonvat N, Periasamy M. Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility. Proc Natl Acad Sci U S A. 2007;104(45):17867-17872.
  • Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai HJ, Kim IH, Tuteja D, Mateo RK, Singapuri A, Davis BB, Low R, Hammock BD, Chiamvimonvat N. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A. 2006;103(49):18733-18738.
  • Timofeyev V, He Y, Tuteja D, Zhang Q, Roth DM, Hammond HK, Chiamvimonvat N. Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy. J Mol Cell Cardiol. 2006;41(1):170-181.
  • Kamp TJ, Chiamvimonvat N. Mission impossible: IGF-1 and PTEN specifically "Akt"ing on cardiac L-type Ca2+ channels. Circ Res. 2006;98(11):1349-1351.
  • Viitasalo M, Oikarinen L, Swan H, Glatter KA, Vaananen H, Fodstad H, Chiamvimonvat N, Kontula K, Toivonen L, Scheinman MM. Ratio of late to early T-wave peak amplitude in 24-h electrocardiographic recordings as indicator of symptom history in patients with long-QT Syndrome types 1 and 2. J Am Coll Cardiol. 2006;47:112-20.
  • Zhang Z, He Y, Tuteja D, Xu D, Timofeyev V, Zhang Q, Glatter KA, Xu Y, Shin HS, Low R, Chiamvimonvat N. Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant mice. Circulation. 2005;112:1936-44.
  • Tuteja D, Xu D, Timofeyev V, Lu L, Sharma D, Zhang Z, Xu Y, Nie L, Vazquez AE, Young JN, Glatter KA, Chiamvimonvat N. Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol. 2005;289:H2714-23.
  • Xu Y, Zhang Z, Timofeyev V, Sharma D, Xu D, Tuteja D, Dong PH, Ahmmed GU, Ji Y, Shull GE, Periasamy M, Chiamvimonvat N. The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice. J Physiol. 2005;562:745-58.
  • Nie L, Song H, Chen MF, Chiamvimonvat N, Beisel KW, Yamoah EN, Vazquez AE. Cloning and expression of a small-conductance Ca(2+)-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors. J Neurophysiol. 2004;91:1536-44.
  • Glatter KA, Chiamvimonvat N. Tachy- or bradyarrhythmias: Implications for therapeutic intervention in LQT3 families. Circulation Research. 92: 941-943, 2003.

    Zhang Z, Xu Y, Dong PH, Sharma D, Chiamvimonvat N. A negatively charged residue in the outer mouth of rat sodium channels determine the gating kinetics of the channels. Am J Physiol Cell Physiol 284:C1247-C1254, 2003.

    Chiamvimonvat N. Diastolic dysfunction and the aging heart. Journal of Molecular and Cellular Cardiology 34:607-610, 2002.
  • Xu Y, Tuteja D, Zhang Z, Xu D, Zhang Y, Rodriguez J, Nie L, Tuxson HR, Young JN, Glatter KA, Vazquez AE, Yamoah EN, Chiamvimonvat N. Molecular identification and functional roles of a Ca-activated K channel in human and mouse hearts. J Biol Chem. 278:49085-94, 2003.
  • Sharma D, Glatter KA, Timofeyev V, Tuteja D, Zhang Z, Rodriguez J, Tester DJ, Low R, Scheinman MM, Ackerman MJ, Chiamvimonvat N. Characterization of a KCNQ1/KVLQT1 polymorphism in Asian families with LQT2: implications for genetic testing. J Mol Cell Cardiol. 2004;37:79-89.
  • Xu Y, Chiamvimonvat N, Akunuru S, Ratner N, Yamoah EN. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. Journal of Neuroscience 22:9194-202, 2002.

    Xu Y, Dong PH, Ahmmed GA, Chiamvimonvat N. Functional roles of the calcium-activated chloride current in mouse ventricular myocytes. American Journal of Physiology 283:H302-H314, 2002.

    Zhang Z, Xu Y, Song H, Rodriguez J, Tuteja D, Namkung Y, Shin HS, Chiamvimonvat N. Functional roles of a1D calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circulation Research 90:981-987, 2002.

    Ahmmed GU, Xu Y, Dong PH, Zhang Z, Eiserich J, Chiamvimonvat N. Nitric oxide modulates cardiac sodium channel via protein kinase A and protein kinase G. Circulation Research 89:1005-1013, 2001.

    Ahmmed GU, Dong PH, Song G, Ball NA, Xu Y, Walsh RA, Chiamvimonvat N. Changes In Ca2+ cycling proteins underlie cardiac action potential prolongation in a pressure overloaded guinea pig model with cardiac hypertrophy and failure. Circulation Research 86:558-570, 2000.

    Ji Y, Lalli MJ, Babu GJ, Xu Y, Kirkpatrick DL, Liu LH, Chiamvimonvat N, Walsh RA, Shull GE, Periasamy M. Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function. Journal of Biological Chemistry 275:38073-38080, 2000.

    Li RA, Velez P, Chiamvimonvat N, Tomaselli G, Marban E. Contributions to permeation of charged residues between the selectivity filter and S6 segments in the rat skeletal muscle (m1-2) Na+ channel. Journal of General Physiology 115:81-92. 1999.
Laboratory Personnel:
Genome and Biomedical Science Facility, 6th floor

Ling Lu, Ning Li, Dipika Tuteja, Valeriy Timofeyev, Anil Singapuri, Padmini Sirish, Hong Qiu, Sassan Rafizadeh

Teaching Interests:
Pharmacology, ion channel electrophysiology
Courses:
PGG 210B Advanced Physiology Winter
PHA 400C Principles of Pharmacology Winter