Kermit Carraway
Professor
klcarraway@ucdavis.edu
Biochemistry and Molecular Medicine
Co-Founder, Breast Cancer Program, UC Davis Cancer Center
Office
Research Bldg. III, Room 1100B, UCDMC
(916) 734-3114
Degrees:
1996
Postdoc,
Harvard Medical School;
Signal Transduction
1992
PhD,
Cornell University;
Biochemistry, Cell and Molecular Biology
1985
BS,
University of Illinois;
Biochemistry
Research Interests:
Cancer biology and therapeutics
Research in the lab centers on elucidating the cellular and molecular mechanisms underlying tumor formation and progression, and developing strategies and agents that could interfere with these processes. We are specifically interested in post-transcriptional regulatory pathways, such as cellular trafficking and degradation of growth factor receptors and disruption of cell polarity pathways, that contribute to cancer malignancy. We use biochemical and cell biological methods to elucidate these pathways in cultured tumor cells, genetically engineered mice to characterize dysregulated tumorigenic pathways in vivo, and drug development and characterization methods to inhibit these pathways.
Department and Center Affiliations:
UC Davis Cancer Center
Med Biochemistry and Molecular Medicine
CBS Graduate Group Affiliations:
Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus:
Biochemistry, Molecular, Cellular and Developmental Biology
Cell and Developmental Biology
Cell Biology
Molecular Medicine
Organelle and Cytoskeleton Dynamics
Signal Transduction and Gene Regulation
Graduate Groups not Housed in CBS:
Pharmacology and Toxicology
Publications:
Last updated 1/7/2012
Carraway, K.L., III, Weber, J.L., Unger, M.J., Ledesma, J., Yu, N.,
Gassmann, M., and Lai, C. 1997. Neuregulin-2, a new ligand of
ErbB3/ErbB4-receptor tyrosine kinases. Nature 387, 512-516.
Carraway, K.L., III, and Sweeney, C. 2001. Localization and modulation of ErbB receptor tyrosine kinases. Curr. Opin. Cell Biol. 13, 125-130.
Diamonti, A.J., Guy, P.M., Ivanof, C., Wong, K., Sweeney, C. and
Carraway, K.L., III. 2002. An RBCC protein implicated in maintenance
of neuregulin receptor levels. Proc. Natl. Acad. Sci. USA 99, 2866-
2871.
Ghiglione, C., Amundadottir, L., Andresdottir, M., Bilder, D., Diamonti, J. A., Noselli, S., Perrimon, N., and Carraway, K.L., III. 2003. Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development 130, 4483-4493.
Wu, X., Yen, L., Irwin, L., Sweeney, C., and Carraway, K. L., III. 2004. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol. Cell. Biol. 24, 7748-7757.
Funes, M., Miller J.K., Lai, C., Carraway, K.L. III, and Sweeney C. 2006. The Mucin Muc4 potentiates Neuregulin signaling by increasing the cell surface populations of ErbB2 and ErbB3. J. Biol. Chem. 281, 19310-19319.
Sweeney, C., Miller, J.K., Shattuck, D.L., and Carraway K.L. III. 2006. ErbB receptor negative regulatory mechanisms: implications in cancer. J. Mammary Gland Biol. Neoplasia 11, 89-99.
Carraway, K.L., III, and Sweeney, C. 2006. Co-opted integrin signaling in ErbB2 induced mammary tumor progression. Cancer Cell 10, 93-5.
Yen, L., Cao, Z., Wu, X., Ingalla, E., Baron, C., Young, L., Gregg, J.P., Cardiff, R.D., Borowsky, A.D., Sweeney, C. and Carraway, K.L., III. 2006. Loss of Nrdp1 enhances ErbB2-ErbB3 dependent breast tumor cell growth. Cancer Res. 66, 11279-86.
Carraway, K.L., III, Funes, M., Workman, H.C., and Sweeney, C. 2007. Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways. Curr. Topics Dev. Biol. 78, 1-22.
Cao, Z., Wu, X., Yen, L., Sweeney, C. and Carraway, K.L., III. 2007. Neuregulin induced ErbB3 down-regulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol. Cell. Biol. 27, 2180-2188.
Fry, W.H., Kotelawala, L., Sweeney, C., Carraway. K.L., III. 2009. Mechanisms of ErbB receptor negative regulation and relevance in cancer. Exp. Cell Res. 68, 8286-8294.
Workman, H.C., Sweeney, C., and Carraway, K.L., III. 2009. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 69, 2845-2852.
Ingalla, E.Q., Miller, J.K., Wald, J.H., Workman, H.C., Kaur, R.P., Yen, L., Fry, W.H.D., Borowsky, A.D., Young, L.J.T., Sweeney, C., and Carraway, K.L., III. 2010. Post-transcriptional regulatory mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. J. Biol. Chem. 285, 28691-28697.
Carraway, K.L., III. 2010. E3 ubiquitin ligases in ErbB receptor quantity control. Sem. Cell Dev. Biol. 21, 936-943.
Fry, W.H., Simion, C., Sweeney, C., and Carraway, K.L. III. Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum. Mol. Cell. Biol. 31, 3009-3018.
Teaching Interests:
Cancer biology; cell biology and metabolism
Courses:
MCB
257
Cell proliferation and cancer genes
Fall
BCM
410B
Med Cell Biology and Metabolism
Winter
BCM
410A
Med Biochemistry
Fall
Key Words:
cancer biology, signal transduction, cell biology, developmental biology