Hongwu Chen
Associate Professor of Med:Biochemisrty & Mol Medicine
hwzchen@ucdavis.edu

Biological Chemistry -Medicine

Office
UCDMC Res III, Rm 1400B
916-734-7743


Picture of Hongwu Chen
 
Degrees:
1999 post-doctoral fellow The Salk Institute for Biological Studies/HHMI, San Diego, CA. Ronald M. Evans' Laboratory
1994 Ph.D. - University of California, Davis
Awards:
American Cancer Society Fellowship, 1997
Department and Center Affiliations:
UCD Cancer Center
Department of Med Biochemsitry & Molecular Medicine
Professional Societies:
American Association for Cancer Research
The Endocrine Society
CBS Graduate Group Affiliations:
Genetics  
Graduate Groups not Housed in CBS:
Pharmacology & Toxicology  
Publications:
  • Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ER{alpha}, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-18072.
  • Louie MC, Revenko AS, Zou JX, Yao J, Chen HW. Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol Cell Biol. 2006, 26(10):3810-23.
  • Louie MC, Zou JX, Rabinovich A, Chen HW. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and anti-estrogen resistance. Mol. Cell. Biol. 2004, 24(12):5157-5171.
  • Louie MC, Yang HQ, Ma AH, Xu W, Zou JX, Kung HJ, Chen HW. Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci U S A. 2003. 100(5):2226-2230.
  • Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B.M., Montminy, M., and Evans, R.M. A transcriptional switch mediated by cofactor methylation. Science. 2001. 294(5551):2507-11.
  • Chen, H., Tini, M., and Evans, R.M.. 2001. HATs on and beyond chromatin. Curr. Opin. Cell Biol.. Vol 13:218-224
Laboratory Personnel:
Research III Bldg., Room 1204, UC Davis Medical Center

Li (Batuloo) Li, postdoc; Alexey Revenko, Graduate student (PTX); Elaine Chu, Graduate student (BMB); Ektarina Kalashnikova, Gradudate student (BMB); Maggie Louie, Graduate student (BMB, 2000-2004); Abigael Gemo, Junior Specialist.

Teaching Interests:
Regulation of gene expression; Molecular and cellular biology of endocrine-related cancer
Courses:
BMB 221C Molecular Genetics
GGG 201C Miolecular Genetics
MCB 200B Molecular Biology Techniques
BCM 410A Molecular & Cellular Biology