Robert H. Fairclough
Associate Professor of Neurology
rhfairclough@ucdavis.edu
Neurology - Medicine
Office
1515 Newton Court, Rm. 510C
530-754-5005
Degrees:
1977
PhD
Columbia University
Chemistry
1967
BA
Yale University
Chemistry
Research Interests:
My lab studies the molecular mechanics of agonist induced channel activation of the nicotinic acetylcholine receptor. We are also mapping the surface domains of the acetylcholine receptor that stimulate the production of pathogenic antibodies in the disease myasthenia gravis.
Department and Center Affiliations:
Neurology
Molecular and Cellular Biology
Professional Societies:
Biophysical Society
AAAS
CBS Graduate Group Affiliations:
Biophysics
Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus:
Biochemistry, Molecular, Cellular and Developmental Biology
Signal Transduction and Gene Regulation
Structural and Mechanistic Biochemistry
Publications:
Last updated 2/11/2013
Fairclough,RH; Twaddle,GM; Gudipati,E; Stone, RJS; Richman, DP; Burkwall,DA; and Josephs,R.. 1998. Mapping the mAb 383C Epitope to alpha2(187-199) of the Torpedo Acetylcholine Receptor on the Three-dimensional Model.. J Mol Biol. 282:301-315
Fairclough, RH; Twaddle, GM; Gudipati, E; Lin, MY; and Richman, DP.. 1998. Differential surface accessibility of alpha(187-199) in the Torpedo ACh receptor alpha-subunits.. J. Mol. Bio.. 282:317-330.
Fairclough, RH; Gudipati, E; Lin, MY; Twaddle, GM; Richman, DP; Burkwall, DA; and Josephs, R.. 1998. A role for alpha(187-199) in the conversion of agonist binding energy to the opening of the ACh receptor ion channel. . Ann. NY Acad. Sci.. 841:87-92
Fairclough, RH; Agius, MA; Gudipati, E; Silvian, L; Hamaoka, B; Beltzner, CC; Lin, MY; Chuang, AR; and Richman, DP. 2003. Agonist-Induced Transitions of the Acetylcholine Receptor. Ann.NY. Acd. Sci. 998:101-113.
Fairclough, RH. 2006. Recalled to life: resurrection of diffusion-enhanced fluorescence energy transfer. Biophys. J. 91(4):1143-4. Epub 2006 Jun 2.
Lee, T; Chuang, AR; Marek, M; Doniach, S; and Fairclough, RH. 2009. Redistribution of Terbium Ions Across Acetylcholine Receptor-Enriched Membranes Induce by Agonist Desensitization. Biophys. J. 96:2637-47.
Teaching Interests:
Biochemistry and biophysics.
Courses:
MCB
120L
Biochemistry Lab
Fall