Aldrin Gomes

image of Aldrin Gomes

Associate Professor

Departments

Physiology and Membrane Biology
Neurobiology, Physiology and Behavior

Offices and Labs

191 Briggs Hall
(530) 752-3207
176 Briggs Hall
(530) 754-9548

Profile Introduction

We are interested in the molecular mechanisms of signal transduction, particularly in muscle contraction and cardiovascular disease. The two main research areas in my laboratory are: the role of the proteasome in normal, protected and diseased cardiac and skeletal muscle and the role of troponin in calcium regulation of muscle contraction in hypertrophic, dilated and restrictive cardiomyopathies.

Degrees

1998 PhD (Biochemistry) University of the West Indies, St. Augustine, Trinidad and Tobago
1991 BS University of the West Indies, St. Augustine, Trinidad and Tobago

Research Interests

Role of Proteasomes and Troponins in cardiac and skeletal muscle tissues. Protein degradation and cardiomyopathies.

Awards

Alpha Omega Merit Award from the University of the West Indies School of Medicine, 1995
Young Scientist Award from the International Union of Biochemistry and Molecular Biology, 1997
American Society Biochemistry and Molecular Biology Travel Fellowship, 2000
Biochemical Society Fellowship, 2000
Scientist Development Grant from the Muscular Dystrophy Association, 2002
American Heart Association Travel Award, 2004
Scientist Developmental Grant from the American Heart Association, 2008
Hellman Fellow, 2010

Department and Center Affiliations

Neurobiology, Physiology and Behavior (NPB), College of Biological Sciences
Physiology and Membrane Biology, School of Medicine

ProfessionalSocieties

American Heart Association (AHA)
American Physiological Society
Biophysical Society
Cardiac Society
Internation Society for Heart Research

CBS Grad Group Affiliations

Molecular, Cellular, and Integrative Physiology
Biochemistry, Molecular, Cellular and Developmental Biology

Publications

3/6/2014 10:53:33 AM
  • Jamart C, Gomes AV, Dewey S, Deldicque L, Raymackers JM, Francaux M. (2014) Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice. BMC Musculoskelet Disord.15:166.

  • Ghosh R, Gilda JE, Gomes AV. (2014) The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 11(5):549-60.

  • Cui, Z., Scruggs, S.B., Gilda, J.E., Ping, P., Gomes, A.V. (2014) Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 71:32-42.

  • Cui, Z., Hwang, S.M., and Gomes A.V. (2014) Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 34(1):96-109.
  • Narashimhan M., Hong J., Atieno N., Muthusamy V.R., Davidson C.J., Abu-Rmaileh N., Richardson R., Gomes A.V., Hoidal J.R., Rajasekaran N.S. (2014) Nrf2 Deficiency Promotes Apoptosis and Impairs Pax7/MyoD Expression in Aging Skeletal Muscle Cells. Free Radical Biology and Medicine. 71:402-14.

  • Wecksler A.T., Hwang S.H., Wettersten H.I., Gilda J.E., Patton A., Leon L.J., Carraway K.L. 3rd, Gomes A.V, Baar K., Weiss R.H., Hammock B.D. (2014) Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 25(4):433-46.
  • Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. (2014)Influence of a constitutive increase in myofilament calcium-sensitivity on calcium-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 15;552-553

  • Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. (2014) Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Human Molecular Genetics. 23(1):209-225.
  • Cui Z, Gilda JE, Gomes AV. (2014) Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 446: 44–52.
  • Dewey, S., Lai, X., Witzmann,F., Sohal, M., Gomes, A.V. (2013) Proteomic Analysis of Hearts from Akita Mice Suggests Increases in Soluble Epoxide Hydrolase and Antioxidative Programming are Key Changes in Early Stages of Diabetic Cardiomyopathy. Journal of Proteome Research, 12(9): 3920–3933.
  • Gomes A.V. (2013) Genetics of Proteasome Diseases. Scientifica. 2013:637629.
  • Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. (2013) Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research, 100(1):63-73
  • Gilda, J.E., Gomes, A.V. (2013) How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. Journal of Molecular Cellular Cardiology, 62(108): 108-110.
  • Gilda, J.E., Gomes, A.V. (2013) Stain free total protein staining is a superior loading control to β-actin for Western blots. Analytical Biochemistry,440(2): 186-188.
  • Rajagopalan, V.,Zhao, M.,Reddy, S., Fajardo, G.,Wang, X., Dewey, S., Gomes, A,V., Bernstein, D. (2013) Altered Ubiquitin-Proteasome Signaling in Right Ventricular Hypertrophy and Failure. American Journal of Physiology, 305(4): H551-62.
  • Xu, Q., Cui, Z., Venkatraman, G., Gomes, A.V. (2012) The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophysical Reviews 4, 125-135.
  • Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. (2012) Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 26:2986-99.
  • Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen ,S., Miller, T., Parvatiyar, M.S,. Potter J.D. (2012) The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 287:37362-70.
  • Iorga, A., Dewey, S., Partow-Navid1, R., Gomes AV, Mansoureh, E. (2012) Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice. PLOS One. 7(11): e48601.
  • Szczesna-Cordary D, Morimoto S, Gomes AV, Moore JR. (2012) Cardiomyopathies:classification, clinical characterization, and functional phenotypes.Biochemistry Research International, 870942.
  • Cui, Z., Dewey, S., Gomes, A.V. (2011) Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am. J. Cardiovasc. Dis. 1: 274-292.
  • Hwee, D.T., Gomes, A.V., Bodine, S.C. (2011) Cardiac Proteasome Activity in Muscle Ring Finger-1 Null Mice at Rest and Following Synthetic Glucocorticoid Treatment. Am. J. Physiol. Endocrinol. Metab. 301:E967-77.
  • Dewey, S., Xu, Q., Gomes, A. (2010) Static and dynamic properties of the HCM myocardium. J Mol Cell Cardiol. 49:715-8.
  • Divald, A., Kivity, S., Wang, P., Hochhauser, E., Roberts, B., Teichberg, S., Gomes, A.V., Powell, S.R., (2010) Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circulation Research. 106: 1829-38.
  • Dewey, S., Gomes, A.V. (2010) Non-Antigen Processing Diabetic Cardiac Immunoproteasomes. J. Mol. Cell. Cardiol. 49: 1-4.
  • Xu, Q., Dewey, S., Nguyen, S., Gomes, A.V. (2010) Malignant and benign mutations in familial cardiomyopathies: Insights into mutations linked to complex cardiovascular phenotypes. J. Mol. Cell. Cardiol. 48: 899-909.
  • Tikunova, S.B., Liu, B., Swindle, N., Little, S.C., Gomes, A.V., Swartz, D.R., Davis, J.P. (2010) Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 49:1975-84.
  • Willott, R.H., Gomes, A.V., Chang, A.N., Parvatiyar, M.S., Pinto, J.R., Potter, J.D. (2010) Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function? J. Mol. Cell. Cardiol. 48:882-92.
  • Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. (2009) Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 8:302-15.
  • Mayr M., Grainger, D., Mayr, U., Leroyer, A.S., Leseche, G., Sidibe, A., Herbin, O., Yin, X., Gomes, A.V., Madhu, B., Griffiths, J.R., Xu, Q., Tedgui, A. and Boulanger, C.M. (2009) Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ. Cardiovasc. Genet. 46268-77.
  • Mayr, M., Liem, D., Zhang, J., Li, X., Avliyakulov, N.K., Yang, J.I., Young, G., Vondriska, T.M., Ladroue, C., Madhu, B., Griffiths, J.R., Gomes, A., Xu, Q., Ping, P. (2009) Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J. Mol. Cell. Cardiol. 46:268-77.
  • Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. (2007) Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 6:2021-2031.
  • Gomes, A.V. Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. (2006) Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.
  • Zong, C., Gomes, A.V. Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. (2006) Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.
  • Gomes, A.V. Zong, C., Ping, P. (2006) Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxidants & Redox Signaling 9/10:1677-1691.
  • Gomes, A.V. et al., (2005) Murine Cardiac 26S Proteasome: An Organelle Awaiting Exploration. Ann N Y Acad Sci. 1047, 197-207.
  • Barnes, J.A,, Singh, S., Gomes, A.V. (2005) Protease activated receptors in cardiovascular function and disease. Mol. Cell Biochem. 263, 227-39.
  • Barnes, J.A,, Gomes, A.V. (2002) Proteolytic signals in the primary structure of annexins. Mol. Cell Biochem. 231, 1-7.
  • Cuervo A.M., Gomes A.V., Barnes J.A., Dice J.F. (2000) Selective Degradation of Annexins by Chaperone-mediated Autophagy. J. Biol. Chem. 275, 33329-33335.
  • Role of Troponins in Muscle Contraction and Disease
  • Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. (2008) Cardiac troponin T forms a tetramer in vitro. Biochemistry. 47, 1970-6.
  • Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. (2008) Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 283:20484-94
  • Gomes, A.V., Liang, J., Potter J.D. (2005). Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 280, 30909-15.
  • Gomes, A.V., Harada, K., Potter J.D. (2005). A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Calcium-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 39, 754-65.
  • Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. (2005) Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 280, 17584-92.
  • Gomes, A.V., Venkatraman, G., Potter, J.D. (2005) The miscommunicative cardiac cell: when good proteins go bad. Ann N Y Acad Sci. 1047, 30-7.
  • Gomes, A.V., Venkatraman, G., Davis, J.P., Tikunova, S.B., Engel, P., Solaro, R.J., Potter J.D. (2004) Cardiac troponin T isoforms affect the Calcium sensitivity of force development in the presence of slow skeletal troponin I: Insights into the role of troponin T isoforms in the fetal heart. J. Biol Chem. 279, 49579-87.
  • Venkatraman, G., Harada K., Gomes, A.V., Kerrick, W.G., Potter, J.D. (2003) Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J. Biol Chem. 278, 41670-6.
  • Gomes, A.V., Guzman, G., Zhao, J., Potter, J.D. (2002) Cardiac troponin T isoforms affect the Calcium-sensitivity and inhibition of force development: insights into the role of troponin T isoforms in the heart. J. Biol Chem. 277, 35341-35349.
  • Lang, R., Gomes, A.V., Zhao, J., Housmans, P.R., Miller, T., Potter, J.D. (2002) Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J. Biol. Chem. 277, 11670-11678.
  • Miller, T., Szczesna, D., Housmans, P.R., Zhao, J., de Freitas, F., Gomes, A.V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W.G. and Potter, J.D. (2001) Abnormal Contractile Function in Transgenic Mice Expressing an FHC-Linked Troponin T (I79N) Mutation. J. Biol. Chem. 276, 3743-3755.
  • Szczesna, D., Ghosh, D., Li, Q., Gomes, A.V., Guzman, G., Arana, C., Zhi, G., Stull, J.T., Potter, J.D.(2001) Abnormal Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Calcium binding and phosphorylation. J. Biol. Chem. 276, 7086-7092.
  • Related Publications
  • Baldán A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. (2008) J Immunol. 180,3560-8.
  • Yuan, T., Gomes, A.V., Barnes, J.A., Hunter, H.N. and Vogel, H.J. (2004) Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I. Arch. Biochem. Biophys. 421, 192-206.
  • Gutierrez-Ford, C., Levay, K., Gomes, A.V., Perera, E.M., Som, T., Kim, Y.M., Benovic J.L., Berkovitz G.D., Slepak V.Z. (2003) Characterization of Tescalcin, a Novel EF-Hand Protein with a Single Calcium-Binding Site: Metal-Binding Properties, Localization in Tissues and Cells, and Effect on Calcineurin. Biochemistry 42, 14553-14565.
  • Gomes A.V., Barnes J.A., Vogel H.J. (2000) Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin. Arch Biochem Biophys. 379, 28-36.

Labs

Muscle Physiology and Proteomics Laboratory/176 Briggs Hall website
  • Ziyou Cui, PhD; Rajeshwary Ghosh, PhD; Shannamar Dewey, BS; Jennifer Gilda, BS;

Courses

EXB 110 Exercise Metabolism (Spring)
MCP 290 Grant Writing (Fall)
NPB 101 Systemic Physiology (Winter)