Christopher Fraser

image of Christopher Fraser

Associate Professor


Molecular & Cellular Biology

Offices and Labs

204 Briggs Hall


1999 PhD Biochemistry University of Sussex
1995 BS Biology University of Sussex


Wellcome Trust Prize Studentship 1995-1998

Department and Center Affiliations

Molecular and Cellular Biology
UC Davis Comprehensive Cancer Center


American Society for Biochemistry and Molecular Biology
Editorial Board Member, Journal of Biological Chemistry (2013-2018)
Editorial Board Member, Molecular and Cellular Biology (2014-2019)

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Graduate Groups not Housed in CBS

Designated Emphasis in Biotechnology Program


204 Briggs Hall
  • Masaaki Sokabe (Postdoc); Nancy Villa (Postdoc); Mario Izidoro (Graduate Student); Katherine Beglinger (Graduate Student); Mattie O'Sullivan (Graduate Student); Helen Jue (Undergraduate Student).


- MCB 214 Molecular Biology (Spring)
- MCB 123 Enzyme Kinetics (Spring)


6/15/2017 12:29:50 PM
  • Avanzino, B. C., Fuchs, G., and Fraser, C. S. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9611-9616.

  • Sokabe, M., and Fraser, C. S. ATP-dependent restructuring of the 40S subunit decoding site during mRNA recruitment. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6304-6309.

  • García-García, C., Frieda, K. L., Feoktistova, K., Fraser, C. S., and Block, S. M. Factor-Dependent Processivity in the Human eIF4A DEAD-box Helicase. Science. 2015 Jun 26;348(6242):1486-8.

  • Sokabe, M., and Fraser, C. S. Human Eukaryotic Initiation Factor 2 (eIF2)-GTP-Met-tRNAi Ternary Complex and eIF3 Stabilize the 43S Preinitiation Complex. J Biol Chem. 2014 Nov 14;289(46):31827-36.

  • Özeş AR, Feoktistova K, Avanzino BC, Baldwin EP, Fraser CS. Real-time fluorescence assays to monitor duplex unwinding and ATPase activities of helicases. Nat Protoc. 2014 Jul;9(7):1645-61.
  • Villa, N., Do, A., Hershey, J. W., and Fraser, C. S. Human eukaryotic initiation factor 4G (eIF4G) binds to eIF3c, -d, and –e to promote mRNA recruitment to the ribosome. J. Biol. Chem. 2013 Nov 15;288(46):32932-40.
  • Feoktistova, K., Tuvshintogs, E., Do, A., and Fraser, C. S. Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc Natl Acad Sci U S A. 2013 110 (33) 13339-13344.
  • Virgili, G., Frank, F., Feoktistova, K., Sawicki, M., Sonenberg, N., Fraser, C. S., and Nagar, B. Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A. Structure. 2013 Apr 2;21(4):517-27.
  • Sokabe M, Fraser CS, Hershey JW. The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit. Nucleic Acids Res. 2012 Jan;40(2):905-13.
  • Ozeş AR, Feoktistova K, Avanzino BC, Fraser CS. Duplex Unwinding and ATPase Activities of the DEAD-Box Helicase eIF4A Are Coupled by eIF4G and eIF4B. J Mol Biol. 2011: 412, 674-687
  • Lindqvist, L., Robert, F., Merrick, W., Kakeya, H., Fraser, C., Osada, H., and Pelletier, J. Inhibition of translation by cytotrienin A--a member of the ansamycin family. RNA 2010 Dec;16(12):2404-13.
  • Lee, S. B., Park, J. H., Folk, J. E., Deck, J.A., Pegg, A. E., Sokabe, M., Fraser, C. S., and Park, M.H. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). Biochem J. 2010 Dec 15;433(1):205-13.
  • Fraser, C. S., Hershey, J. W., and Doudna, J. A. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat. Struct. Mol. Biol. 2009 Apr;16(4):397-404.
  • Fraser, C. S., Berry, K. E., Hershey, J. W., and Doudna, J. A. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol. Cell. 2007 Jun 22;26(6):811-9.