Diana G. Myles

image of Diana G. Myles

Professor Emerita


Molecular & Cellular Biology

Offices and Labs

3167 Life Sciences Addition


1973 PhD Botany University of California, Berkeley
1968 BA Botany University of California, Berkeley

Research Interests

The role of the ADAM family, integrins and other proteins in sperm-egg mammalian membrane adhesion and membrane fusion. Sperm membrane polarity and protein-protein interactions during spermatogenesis. A variety of approaches are used including mouse genetics (knockouts and transgenics), molecular biology and protein biochemistry.

Teaching Interests

Cell biology, developmental biology, and fertilization.


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  • Cho, C., Bunch, D.O., Faure, J.-E., Goulding, E.H., Eddy, E.M., Primakoff, P. and Myles, D.G.. 1998. Fertilization defects in sperm from mice lacking fertilin . Science. 281 :1857-59.
  • Primakoff, P and D.G. Myles. 2000. The ADAM gene family: Surface proteins with adhesion and protease activity. Trends Genet.. 16:83-87
  • Miller, B., Georges-Labouesse, E., Primakoff, P. and Myles, D.G.. 2000. Normal fertilization occurs in eggs lacking the integrin 6 1 and is CD9-dependent.. J. Cell Biol. . 149: 1289-1295.