Raymond Rodriguez

image of Raymond Rodriguez



Molecular & Cellular Biology

Offices and Labs

1139 Plant Reproductive Biology Facility
(530) 756-5153
(530) 752-2278 Fax
752-3613 (Dr. Somen Nandi)


2009 Ph.D (honorary) Biology Nara Institute of Science and Technology (NAIST)
1974 PhD Biology University of California, Santa Cruz
1969 BA Biology California State University, Fresno

Research Contribution

Global HealthShare is a project-based program dedicated to promoting health and wellness in developing countries around the world through the power of sharing knowledge, technology and resources. GHS mission to increase global economic citizenship; one healthy village at time represents a new paradigm for the 21st century. Through our global network of academic institutions, humanitarian organizations and private sector partners, GHS uses proven technologies to deliver nutritional and health-based solutions to prevent human hunger and disease in the developing world. By linking innovative enterprise development models to animal, human, and community health, GHS believes it can break the pernicious cycle of poverty and disease that enslaves billions of people to the bottom of the economic pyramid. By focusing its micro-interventions on key performance indicators along the food/ag value chain, GHS believes is helping smallholder farmers and entrepreneurs achieve, affordable, sustainable and culturally appropriate benefits for their communities and region. By incorporating information communications technology (ITC), wireless connectivity and social networking, GHS believes the benefits of its interventions and enterprise models will become self-managing, self-propagating and self-sustaining as they spread from region to region and country to country. As an accelerator of translational research, GHS members and partners are committed to sharing their collective assets (e.g., expertise, intellectual property, materials, infrastructure, and capacity) to achieve its mission and goals. GHS will combine proven technologies and the latest advances in nutrition and health into innovative, affordable, and life-saving solutions for vulnerable populations around the world. GHS approach is based on the following principles: • Identify solutions and enterprise models that will benefit large, underserved populations currently neglected by profit-driven organizations. • Partner with industry, scientists, healthcare professionals, institutions, and organizations to improve health and wellness by delivering the benefits of GHS interventions, technologies and enterprise models. • Leverage the resources needed to support downstream development (i.e., product formulation, clinical trials, delivery process, etc.) rather than on discovery research or major capital expenditures. • Promote self-sufficiency and sustainability through the dissemination of knowledge and training to targeted populations using experiential, classroom and online instruction. • Empower women and girls with the tools needed to improve themselves and the communities they live in.

Research Interests

Nutritional genomics is the study of diet-gene interactions on a whole genome scale with the goal of developing innovative solutions to disease prevention, diagnosis, and treatment. There are a few already known well-characterized examples of diet-gene interactions affecting human health: e.g., lactose intolerance, phenylketonuria, galatosemia, gluten-sensitive enteropathy, and familial hypercholesterolemia. In these classic examples, disease-specific genetic polymorphisms are identified, their population distributions are known, and clinical dietary guidelines are developed for disease prevention and treatment. In addition to these disease conditions, many common chronic diseases: e.g., obesity, diabetes, cardiovascular disease, breast cancer, and prostate cancer, are also associated with diet as a risk or course-modifying factor. However, the genetic background of these polygenic diseases is more complex and the mechanistic explanations of the diet-gene interactions could become possible only with the recent advances in post-genomic (omic) technologies. The chemopreventive properties of a soy-based polypeptide is being investigated using microarray analysis of human cells and small animal models. This peptide has been shown to remodel chromatin structure and to up-regulate genes related to tumor suppression, apoptosis, cell cycle control and DNA repair.


Outstanding Faculty Advisor Award, Div. Biol. Sci., 1996-1997; Distinguished Service Award from the College of Agricultural and Environmental Sciences, UC Davis, 1988; National Cancer Institute Postdoctoral Fellowship, 1976-1977; A. P. Giannini Foundation Postdoctoral Fellowship, 1974-1976; Ford Foundation Graduate Fellowship, 1973-1974
2008-USDA-ARS Beltsville Center Distinguished Lecturer
2013-Fellow, American Association for the Advancement of Science

Department and Center Affiliations

Director, Center of Excellence in Nutritional Genomics
Global HeathShare - UC Davis


American Association for the Advancement of Science; American Chemical Society; Sigma Xi Society
Society for Hispanic Professional Engineers

Specialties / Focus

Plant Biology
  • Molecular Biology, Biochemistry and Genomics


Global HealthShare Inititive website
  • Dr. Somen Nandi

Teaching Interests

Genes and gene expression, recombinant DNA and genetic engineering, biotechnology and nutritional genomics.


BIS 101 Genes and Gene Expression (Spring)
MCB 178 Nutritional Genomics (Fall)
MCB 263 Fundamentals of Biotechnology (Winter)
MCB 294 Biotechnology Seminar Program (Fall,Winter,Spring)

Personal Interests

5 things about me website


8/29/2017 2:03:25 PM
  • Rodriguez, R.L,  Albeck, J.G, Taha, A,Y., Ori-McKenney K.M., Recanzone, G.H., Stradleigh,T. W., Hernandez, B.C., Tang, F-Y V., Chiang, E-P., I., Cruz-Orengo, L. 2017. Impact of Diet-derived Signaling Molecules on Human Cognition: Exploring the Food-Brain Axis. Science of Food, 1http://rdcu.be/xUdM.

  • Chiu, S-C, Chao, C-Y, Chiang, E-P, I., Syu, J-N, Rodriguez, R.L., Tang, F-T, 2017. N-3 polyunsaturated fatty acids alleviate high glucose-mediated dysfunction of endothelial progenitor cells and prevent ischemic injuries both in vitro and in vivo. J. Nutr. Biochem. 42:172-181.

  • Kuo, Y-H, Chiang E-P I., Chao, C-Y, Rodriguez, R.L., Chou, P-Y, Tsai, S-Y, Pai, M-H and F-Y Tang. 2016. Dual Inhibition of Key Proliferation Signaling Pathways in Triple-Negative Breast Cancer Cells by a Novel Derivative of Taiwanin A. Molec. Cancer Ther., 16(3):480-493.

  • Kalimuthu Karuppanan, Sifti Duhra-Gill, Muchena J. Kailemia, My L. Phu, Carlito Lebrilla, Abhaya M. Dandekar, Raymond L. Rodriguez, Somen Nandi, Karen McDonald. 2016. Expression, Purification, and Biophysical Characterization of a Secreted Anthrax Decoy Fusion Protein in Nicotiana benthamiana. Intl. J. Molec. Sci. 4;18(1). pii: E89. doi: 10.3390/ijms18010089.


  • Corbin, J.M., Hashimoto, B.I., Karuppanan, K., Kyser, Z. R., Wu, L., Roberts, B.A., Noe, A.R., Rodriguez, R.L., McDonald, K.A., and Nandi, S. (2016) Semicontinuous bioreactor production of recombinant butyrylcholinesterase in transgenic rice cell suspension cultures. Frontiers in Plant Science, 7 (412): 1-8, https://doi.org/10.3389/fpls.2016.00412.

  • Alkanaimsh, S., Karuppanan, K., Guerrero, A., Tu, A., Hashimoto, B., Hwang, M-S, Phu, M., Arzola, L., Lebrilla, C., M. Dandekar, A., Falk, B.W., Nandi, N., Rodriguez, R.L., and McDonald, K. (2016) Transient Expression of Tetrameric Recombinant Human Butyrylcholinesterase in Nicotiana benthamiana. Frontiers in Plant Science,16:7:743.

  • Nandi, S., Thota, S., Nag, A., Divyasukhananda, S., Goswami, P., Aravindakshan, A., Rodriguez, R.L., and Mukherjee, B. (2016). Computing for Rural Empowerment: Enabled by Last-Mile Telecommunications. IEEE Communications Magazine 54(6): 102-109. DOI: 10.1109/MCOM.2016.7498095

  • Chiang, E-P, Tsai, Y., Kuo, Y-H, Pai, M-H, Chiu, H-L, Rodriguez, RL, Tang, F-Y. 2014. Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways. PLOS One, DOI:10.1371
  • Dawson, K., Zhao, L., Adkins, Y., Vemuri, M., Rodriguez, R.L., Gregg, J.P., Kelley, D. S. and Hwang, D.H. 2012. DHA supplementation suppresses LDL receptor and oxidized LDL receptor gene expression in blood cells from hypertriglyceridemic men. J. Nutritional Biochem. 23:616–621
  • Langridge, W., Odumosu, O., Nandi, S., Rodriguez, R.L., DeLeon, M. and Cordero-MacIntyre, Z. 2012. Mucosal Vaccination against Enteric Pathogens in the Developing World. British Journal of Medicine and Medical Research. 2:260-291.
  • Nutritional Genomics: Impact of Dietary Regulation of Gene Function on Human Disease. Bidlack, W. and R. L. Rodriguez, Taylor and Francis/CRC Press, December 2011.
  • Jun, H-J, Kim, S., Dawson, K., Choi, D-W, Kim, J-S, Rodriguez, R. L. and Lee, S-J. 2011. Effects of Acute Oral Administration of Vitamin C on the Mouse Liver Transcriptome. J. Med. Food. 14:1-14.
  • Galvez, A.F., Huang, L., Magbanua, M.M.J. Dawson, K., Nandi, S. and R. L. Rodriguez. 2011. Diet-influenced Chromatin Modification and Expression of Chemopreventive Genes by the Soy Peptide, Lunasin, in Nutritional Genomics: Dietary Regulation of Gene Function on Human Disease. Bidlack, W. and R. L. Rodriguez, eds. Taylor and Francis/CRC.

  • Galvez, A.F., Huang, L., Magbanua, M.M.J. Dawson, K. R. L. Rodriguez. 2011. Differential Expression of Thrombospondin (THBS1) in Turmorigenic and Nontumorigenic Prostate Epithelial Cells in Response to a Chromatin-Binding Soy Peptide. Nutrition and Cancer. 63(4):623-636.
  • Jun, H-J, Chung, M-J, Dawson, K. Rodriguez, R.L., Houng, S-J, Cho, S-Y, Jeun, J., Kim, J-Y, Kim, K-H, Park, K. W., Kim, C.-T. and Lee, S-J. 2010. Nutrigenomic Analysis of Hypolipidemic Effects of Agastache rugosa Essential Oils in HepG2 Cells and C57BL/6 Mice. Food Sci. Biotechnol. 19(1):219-227.
  • Park, K-H and Lee, S-J. 2010. Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes. Eur. Food Res. Technol. DOI 10.1007/s00217-010-1251-5.
  • Nelson, E.C., Rodriguez, R.L., Dawson, K. Galvez, A. and Evans, C. 2008. The interaction of genetic polymorphisms with lifestyle factors: implications for Dietary Prevention. Nutrition and Cancer 60:301-312. Choi, Y-M, Jun, H-J, Dawson, K., Rodriguez, R.L., Roh, M-R, Jun, J., Choi, C-H, Choi, Shim, J-H, Lee, C-H, Lee, S-J,
  • Dawson, K., Rodriguez, R.L., Hawkes, W.C. and Malyj, W. 2006. Biocomputation and the analysis of complex data sets in nutritional genomics, in Nutrigenomics: Discovering the Path to Personalized Nutrition, John Wiley & Sons, New Jersey, pp. 375-401.
  • Kaput, J. and Rodriguez, R.L. 2006. Nutrigenomics: Discovering the Path to Personalized Nutrition, John Wiley & Sons, New Jersey.