Kaz Shiozaki

image of Kaz Shiozaki

Adjunct Professor


Microbiology and Molecular Genetics


1992 PhD Biochemistry/Molecular Biology Kyoto University
1989 MS Biochemistry Kyoto University
1987 BS Biology Kyoto University

Research Interests

My laboratory utilizes fission yeast as a genetically amenable model system to elucidate the regulation and function of the stress MAPK cascade and the TOR (Target Of Rapamycin) signaling pathway.


Human Frontier Science Program, Long-term Research Fellow
American Cancer Society, California Division, Senior Research Fellow
National Academies Education Fellow in Life Science

Department and Center Affiliations

UC Davis Cancer Center


American Society for Cell Biology
American Association for the Advancement of Science

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine

Teaching Interests

Intracellular signal transduction in eukaryotes. Yeast genetics and cell biology.


BIS 104 Regulation of Cell Function
MIC 170 Yeast Molecular Genetics


1/19/2012 5:20:32 PM
  • Tatebe H and K Shiozaki. 2010. Rab small GTPase emerges as a regulator of TOR complex 2. Small GTPases 1: 180-182.
  • Tatebe H, S Morigasaki, S Murayama, CT Zeng and K Shiozaki. 2010. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Current Biology 20: 1975-1982.
  • Morigasaki S and K Shiozaki. 2010. Two-component signaling to the stress MAP kinase cascade in fission yeast. Methods in Enzymology 471: 279-289.
  • Shiozaki K. 2009. Nutrition-minded cell cycle. Science Signaling 2: pe74
  • Morigasaki S, K Shimada, A Ikner, M Yanagida and K Shiozaki. 2008. Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Molecular Cell 30: 108-113.
  • Tatebe H, K Nakano, R Maximo and K Shiozaki. 2008. Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Current Biology 18: 322-330.
  • Ikeda K, S Morigasaki, H Tatebe, F Tamanoi and K Shiozaki. 2008. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7: 358-364.
  • Wang L and K Shiozaki. 2006. The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. FEBS Letter 580: 2409-2413.
  • Tatebe H, K Shimada, S Uzawa, S Morigasaki and K Shiozaki. 2005. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Current Biology 15: 1006-1015.
  • Wang L, K Shimada, M Morishita and K Shiozaki. 2005. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase, Spc1/Sty1, and the Hal4 protein kinase. Molecular and Cellular Biology 25: 3945-3955.
  • Ikner A and K Shiozaki. 2005. Yeast signaling pathways in the oxidative stress response. Mutation Research 569:13-27.
  • Tatebe H and K Shiozaki. 2003. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Molecular and Cellular Biology 23:5132-5142.
  • Nguyen AN, AD Ikner , M Shiozaki, SM Warren, and K Shiozaki. 2002. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Molecular Biology of the Cell 13:2651-2663.
  • Santos JL and K Shiozaki. 2001. Fungal histidine kinases. Science's STKE 2001(98): RE1.