Neil Hunter

image of Neil Hunter

Professor

Departments

Molecular & Cellular Biology
Cell Biology & Human Anatomy
Microbiology and Molecular Genetics

Offices and Labs

347C, Briggs Hall
(530) 754-4401
(530) 754-4391

Profile Introduction

The Hunter lab studies the mechanism and regulation of homologous recombination, an essential DNA repair process that is required for genome stability and accurate chromosome segregation during meiosis.

Degrees

1996 PhD Genetics Wolfson College, Oxford University, Oxford (UK)
1992 BS Biochemistry and Applied Molecular Biology University of Manchester (UK)

Research Contribution

Homologous recombination is an essential DNA repair process that preserves genome integrity, facilitates chromosome segregation during meiosis and generates diversity by mixing parental alleles. Defective recombination is associated with cancer, infertility, pregnancy miscarriage and birth defects.

Research Interests

Homologous Recombination.

The mechanism and regulation of chromosome repair by homologous recombination and its role in chromosome transmission and genome stability.

Post-Translational Protein Modification in Meiosis.

The nature and function of post-translational modifications of proteins involved in chromosome metabolism during meiosis.

Awards

1997-2001 Wellcome Trust - Prize Travelling Postdoctoral Fellowship
1993-1996 Wellcome Trust - Prize PhD Studentship
2003-2006 Damon Runyon Cancer Foundation - Scholar Award
2004-2006 Concern Foundation - Young Investigator Award
2005 March of Dimes - Basil O'Connor Award
2006 France-Berkeley Fund Award
2007 UCD Mutant Mouse Regional Resource Center Award
2009 Early Career Scientist of the Howard Hughes Medical Institute
2009-2014 Chancellor's Fellow
2013 Investigator of the Howard Hughes Medical Institute

Department and Center Affiliations

Microbiology & Molecular Genetics
UC Davis Cancer Center
Molecular & Cellular Biology
Cell Biology & Human Anatonmy

ProfessionalSocieties

The Genetics Society of America
American Association for the Advancement of Science
Society for Developmental Biology

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology
Integrated Genetics and Genomics

Specialties / Focus

Integrated Genetics and Genomics
  • Chromosome Biology
Biochemistry, Molecular, Cellular and Developmental Biology
  • Reproductive Biology
  • Chromosome Dynamics and Nuclear Function
  • Cell Biology

Graduate Groups not Housed in CBS

Microbiology

Publications

10/13/2014 11:58:57 AM
  • Qiao, H, Rao, H.B.D.P, Yang, Y, Fong, J.H., Cloutier, J.M, Deacon, D.C., Nagel, K.E., Swartz, R.K., Strong, E., Holloway, J.K., Cohen, P.E., Schimenti, J., Ward, J., and Hunter, N. (2014). Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nature Genetics doi:10.1038/ng.2858

  • Copsey, A., Tang, S*. Jordan, P., Blitzblau, H., Newcombe, S., Lambacher, N. Chan, A.C., Newnham, L., Li, Z., Arumugam, P., Hochwagen, A., Hunter, N., Hoffmann, E. (2013). Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genetics 9, e1004071, doi:10.1371/journal.pgen.1004071

    *Shangming Tang from the Hunter lab is joint first author.

  • Lao, J.P.*, Cloud, V., Grubb, J., Huang, C-C., Thacker, D., Lee, C-Y., Dresser, M.E., Hunter, N. and Bishop(2013). Meiotic crossover control by concerted action of Rad51-Dmc1 in homolog template bias and robust homeostatic regulation. PLoS Genetics 9, e1003978, doi: 10.1371/journal.pgen.1003978

    *Jessica Lao from the Hunter lab is joint first author; Hunter and Bishop are corresponding authors.

  • Reynolds, A., Qiao, H., Yang, Y., Chen, J., Biswas, K., Holloway, K., Baudat, F., de Massy, B., Wang. J., Höög, C., Cohen, P. and Hunter, N. (2012). RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nature Genetics 45, 269–278. PMID: 23396135

  • Qiao H., Chen, J., Reynolds, A., Höög, C., Paddy, M. and Hunter, N. (2012). Interplay between centromeres, synaptonemal complex and homologous recombination during mammalian meiosis. PLoS Genetics 8, e1002790. PMCID: PMC3386176

  • Biswas, K., Das, R., Eggington, J.M., Huanyu Qiao, H., North, S.L., Stauffer, S., Burkett, S., Betty K. Martin, B.S., Southon, E, Sizemore, S.C., Pruss, D., Bowles, K.R., Roa, B.B., Hunter, N., Tessarollo, L., Wenstrup, R.J., Byrd, R.A. and Sharan, S.K. (2012). Functional evaluation of BRCA2 variants mapping to the PALB2 binding and C-terminal DNA binding domains using a mouse ES cell–based assay. Human Molecular Genetics 21, 3993-4006. PMCID: PMC3428152

  • Zakheryevich, K, Tang, S., Ma, Y. and Hunter, N. (2012). Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase. Cell 149, 334-47.
  • Hunter, N. (2011). Double Duty For Exo1 During Meiotic Recombination. Cell Cycle 10(16), 2607-2609.
  • Hwang, Y-H. and Hunter, N. (2011). Mapping meiotic breaks: Spo11 oligonucleotides precisely mark the spots. Genome Biology 12, 111-114. doi:10.1186/gb-2011-12-4-111.
  • Zakheryevich, K, Ma, Y., Tang, S., Hwang, Y-H., Boiteux, S. and Hunter, N. (2010). Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand-break resection and resolution of double-Holliday Junctions. Molecular Cell, 40, 1001-1015.
  • Lao, J.P. and Hunter, N. (2010). Trying to avoid your sister. PLoS Biology, 8(10): e1000519.
  • Bzymek,M., Thayer, N. H., Oh, S. D., Kleckner, N. and Hunter, N. (2010). Double Holliday Junctions are Intermediates of DNA Break Repair. Nature 464, 937-941.
  • Oh S.D., Lao, J.P. and Hunter, N. (2008). RecQ Helicase, Sgs1, and XPF-Family Endonuclease, Mus81-Mms4, Resolve Aberrant Joint Molecules During Meiotic Recombination. Molecular Cell 31, 324-336.
  • Hunter, N. (2008). Hop1 and the meiotic DNA-damage response. Cell 132, 731-732.
  • Hunter, N. (2008). The RecQ DNA helicases: Jacks-of all-trades or master-tradesmen? Cell Research 18, 328-330.
  • Lao, J.P., Oh, S.D., Shinohara, M., Shinohara, A. and Hunter, N. (2008). Rad52 promotes post-invasion steps of meiotic double-strand-break repair. Molecular Cell, 29, 517-524.
  • Shinohara, M, Oh, S.D., Hunter, N. and Shinohara, A. (2008). Crossover assurance and crossover interference are distinctly regulated by the ZMM/SIC proteins during meiosis. Nature Genetics, 40, 299-309.
  • Oh S.D., Lao, J.P., Hwang, P.Y-H., Taylor, A.F., Smith, G.R. and Hunter, N. (2007). Sgs1, a Bloom's helicase ortholog, prevents aberrant crossing-over by suppressing the formation of multichromatid joint molecules. Cell 130, 259-272.
  • Hunter, N. (2006). Meiotic Recombination. In, Molecular Genetics of Recombination, Aguilera, A. and Rothstein, R. (Eds), Topics in Current Genetics, Springer-Verlag, Heidelberg.
  • Cromie, G. A., Hyppa, R. W., Taylor, A. F., Zakharyevich, K., Hunter, N., and Smith, G. R. (2006). Single Holliday Junctions are intermediates of meiotic recombination. Cell 127, 1167-1178.
  • Martini, E., Diaz, R.L., Hunter, N. and Keeney, S. (2006). Crossover homeostasis in yeast meiosis. Cell 126, 285-295.
  • Hunter, N. (2004). Meiosis. In, the Encyclopedia of Biological Chemistry, Lennarz, W. and Lane, M. (Eds), Elsevier Press, San Diego. pp 610-616.
  • Boerner, V.G., Kleckner, N. and Hunter, N. (2004). Crossover/noncrossover differentiation, synaptonemal complex formation and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell 117, 29-45.
  • de los Santos, T., Hunter, N., Lee, C., Larkin, B., Loidl, J., and Hollingsworth, N.M. (2003). The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast. Genetics, 164, 81-94.
  • Blat, Y., Protacio, R., Hunter, N. and Kleckner, N. (2002). Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation. Cell, 111 791-802.
  • Hunter, N. and Kleckner, N. (2001). The single-end invasion: an asymmetric intermediate at the double-strand-break to double-Holliday junction transition of meiotic recombination. Cell 106, 59-70.

Labs

345, 347 & 351 Briggs Hall website
  • Graduate Students: Shangming Tang, Mary Corrigan, Weiru Liu. Postdoctoral Fellows and Research Scientists: Nikhil Bhagwat, Wei He, June Chu-Chun Huang, Masayoshi Honda, Dhananjaya Kulkarni, Joe Huanyu Qiao, Prasad Rao, Sumit Sandhu. Research Specialist: Jared Fong. Technician: Ping-ping Lu.

Teaching Interests

Genetics. Chromosome biology. Genome instability and cancer biology.

Courses

BIS 101 Genes and Gene Expression (Winter)
MIC 91/191 Introduction to Research (Spring)
MIC 276 Adv Concepts DNA Metab (Spring)
GGG 295 Seminars In Molecular Genetics (Fall)