Irwin H. Segel

image of Irwin H. Segel

Professor Emeritus

Offices and Labs

25A Briggs Hall
(530) 752-3193


1962 PhD Biochemistry University of Wisconsin
1960 MS Biochemistry University of Wisconsin
1957 BS Chemistry Rensselaer Polytechnic Institute, New York

Research Interests

Enzymology, physiology, and regulation of sulfur metabolism with emphasis on the enzymes of inorganic sulfate activation in fungi, plants, animals, and bacteria. Enzymes of thermophilic fungi

Graduate Groups not Housed in CBS


Teaching Interests

Bioenergetics and metabolic regulation. Enzyme kinetics and receptor-ligand interactions.


5/21/2010 9:26:34 AM
  • MacRae I. J., Segel, I. H., and Fisher, A. J.. 2000. Crystal Structure of APS Kinase from Penicillium chrysogenum.. Biochemistry. 39:1613 - 1621
  • MacRae, I. J., Hanna, E., Ho, J. D., Fisher, A. J., and Segel, I. H. . 2000. Induction of positive cooperativity by amino acid replacements within the C-terminal domain of P. chrysogenum ATP sulfurylase.. Journal of Biological Chemistry. 275:36303-36310
  • MacRae, I., A. B. Rose, and Segel, I. H.. 1998. Adenosine 5'-Phosphosulfate (APS) Kinase from Penicllium chrysogenum: Site Directed Mutagenesis Studies on Putative Phosphoryl-Accepting and ATP P - Loop residues. . Journal of Biological Chemistry. 273: