Anne B. Britt
Offices and Labs
2249 Life Sciences
|1986||PhD||Biochemistry||University of California, Berkeley|
|1981||BS||Biology||Massachusetts Institute of Technology|
Our research provides the molecular genetic tools, and the understanding of basic mechanisms, required for practical applications in two different areas. Research into DNA repair and damage response pathways may enable us to modify resistance to environmental toxins such as excessive light, ozone and UV-B. Our work on DSB repair pathways may provide powerful new tools for the manipulation of transgenesis and mutagenesis in higher plants.
Genetics of DNA repair and mutagenesis in the higher plant Arabidopsis. How plants repair and/or tolerate DNA damage generated by chemicals, UV light, and gamma radiation. Processes of genetic recombination, in meiotic and mitotic cells. Transcriptional regulation of damage response.
Department and Center Affiliations
Department of Plant Biology
Genetics Society of America
American Society of Plant Bologists
Maize Genetics Society
CBS Grad Group Affiliations
Integrated Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus
- Cell and Developmental Biology
- Molecular Biology, Biochemistry, and Genomics
- Environmental and Integrative Biology
Integrated Genetics and Genomics
- Chromosome Biology
- Model Plants
8/24/2011 9:05:01 AM
"Breadth by depth: Expanding our understanding of the repair of transposon-induced DNA double strand breaks via deep-sequencing" N.D.Huefner, Y. Mizuno, C.F.Weil, I. Korf, A.B. Britt DNA Repair, (2011).
A shared DNA-damage-response pathway for induction of stem-cell death by UV-B and by gamma irradiation” T. Furukawa, M.J. Curtis, C. Tominey; Y. H. Duong, B. W. Wilcox, D.Aggoune; J. B. Hays; A. B Britt, DNA Repair, 9 940-948 (2010).
Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage. K. Yoshiyama, P.A. Conklin, N. D. Huefner, A.B. Britt. Proc Natl Acad Sci (2009) 106(31):12843-8.
Both ATM and ATR promote the efficient and accurate processing of programmed meiotic double-strand breaks. K. M. Culligan, A. B. Britt. Plant Journal (2008) 55(4):629-38.
ATR and ATM play distinct roles in response to ionizing radiation K. M. Culligan, C. E. Robertson, J. Foreman, P. Doerner, and A. B. Britt, Plant Journal, 48 947-961 (2006).
Tissue-specific regulation of cell-cycle responses to DNA damage in Arabidopsis seedlings E. Hefner, N. Huefner, and A. B. Britt, DNA Repair, 5 102-110 (2006).
Ionizing radiation-dependent gamma-H2AX focus formation requires ATM and ATR. J. D. Friesner, B. Liu, K. M. Culligan, and A. B. Britt, Molecular Biology of the Cell,16 2566-2576 (2005).
ATR regulates a G2-phase cell cycle checkpoint in Arabidopsis thaliana K. M. Culligan and A. B. Britt, Plant Cell, 16 1091-1104 (2004).
A DNA damage-induced checkpoint in plants. S. B. Preuss and A. B. Britt, Genetics, 164:323-334 (2003).
Ku80 and DNA Ligase IV deficient plants are sensitive to ionizing radiation and defective in T-DNA integration. J. D. Friesner and A. B. Britt, Plant Journal, 34 427-440 (2003).
Arabidopsis mutants sensitive to gamma radiation include the homolog of the human repair gene ERCC1 E. A. Hefner, S. B. Preuss, and A. B. Britt, J. Exp. Bot., 54 669-680 (2003).
Reengineering plant transformation A. B. Britt and G. May, Trends in Plant Sciences,8 90-95.
MCB 160L Genetics Lab
GGG 201A Advanced Genetics Analysis
PLB 227 Plant Molecular Biolgoy