Offices and Labs
Profile IntroductionMolecular studies of metabolic regulation and human disease
|2002||MD PhD||Harvard Medical School|
Molecular studies of metabolic regulation and human disease
Dr. Yoon's laboratory is interested in the roles of intercellular signaling pathways in the regulation of cellular metabolism and their impact on physiological and pathological processes, with a particular focus on diabetes mellitus. Another area of interest is the contribution of mitochondrial defects and inflammatory processes to the development of metabolic disease. Large-scale genetic screens in muscle cells have been performed to isolate regulators of mitochondrial function and some of the identified genes are being characterized. Human and mouse cell culture and genetic mouse models are utilized.
Department and Center Affiliations
CBS Grad Group Affiliations
Specialties / Focus
- Metabolic Physiology
- Molecular Physiology
Yoon JC, Ling AL, Isik M, Lee DD, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT-1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci USA. 2014;111: 3781-3786.
Davoli T, Xu W, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013;155:948-962.
Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010;24:1507-1518.
Puigserver, P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili, and Spiegelman BM. Insulin-Regulated Hepatic Gluconeogenesis through FOXO1-PGC-1α Interaction. Nature. 2003;423(6939):550-555.
Yoon JC, Puigserver P, Chen G, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, and Spiegelman BM. Control of Hepatic Gluconeogenesis through the Transcriptional Coactivator PGC-1. Nature. 2001;413:131-138.