|2004||PhD||Cell and Developmental Biology||Rutgers University|
|1995||BS||Life Science||National Tsing Hua University, Taiwan|
Centrosomes and Cilia in Cell and Developmental Biology
We study how the centrosome and the cilium coordinate signals that regulate cell function and influence development. Our research focuses on how the pericentriolar material (PCM) is organized and how it contributes to centrosome maturation. We also investigate how centrosomal dysfunction at the cellular level is translated into developmental defects at the organismal level. We use zebrafish, tissue culture systems, and a variety of molecular, genetic, and biochemical approaches. We also use advanced microscopy in our study. Current projects focus on how the PCM is dynamically organized at different cell cycle stages and how the neurogenesis program is affected upon centrosomal dysfunction during zebrafish early development.
Department and Center Affiliations
CBS Grad Group Affiliations
Specialties / Focus
- Molecular Genetics
- Cell Biology
- Developmental Biology
- Cancer Biology
- Cell Division and the Cytoskeleton
- Differentiation, Morphogenesis and Wound Healing
- Gene Regulation
- Genomics, Proteomics and Metabolomics
- Organelle and Membrane Biology
- Signal Transduction
- Stem Cell Biology
- Model Organism Genetics
- Developmental Genetics
Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation.
Sepulveda G, Antkowiak M, Brust-Mascher I, Mahe K, Ou T, Castro N, Christensen LN, Cheung L, Yoon D, Huang B, and Jao LE. BioRxiv. doi: https://doi.org/10.1101/241083.
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