|2010||PhD||Biomedical Engineering||Duke University|
|2002||MS||High Performance Computing||Singapore-MIT Alliance|
Synthetic biology, artificial cells, and antibiotic treatment
My lab is interested in the engineering of synthetic biological systems for therapeutic treatment. To achieve this long term goal, we pursue two fundamental directions in parallel. To improve the control of synthetic cellular systems, we harness functioning mechanisms of natural cells to control dynamics of synthetic cells. In addition, we investigate how heterogenous cellular populations respond to drug treatment. We aim to merge the two directions to create novel treatment strategies using artificial cellular systems. Our work is multi-disciplinary and strives to create new frontier in synthetic & quantitative biology by synergizing ideas from different fields.
CBS Grad Group Affiliations
Specialties / Focus
- Molecular Genetics
- Cell Biology
- Gene Regulation
- Molecular Medicine
- Molecular Microbiology
- Signal Transduction
- Cellular Responses to Toxins and Stress
- Computational Biology
- Synthetic Biology
Graduate Groups not Housed in CBS
C. Tan, S. Saurabh, M. Bruchez, R. Schwartz, and P. LeDuc.
Shaping gene expression in artificial cellular systems by cell-inspired molecular crowding.
Nature Nanotechnology, 2013.
C. Tan*, R. Smith*, J. Srimani, K. Riccione, S. Prasada, M. Kuehn, and L. You. (*Equal contribution).
The inoculum effect and band-pass bacterial response to periodic antibiotic treatment.
Molecular Systems Biology, 2012
C. Tan, S. Lo, P. LeDuc, and CM. Cheng.
Frontiers of optofluidics in synthetic biology.
Lab on a Chip, 2012
C. Tan, P. Marguet, and L. You.
Emergent bistability by a growth-modulating positive feedback circuit.
Nature Chemical Biology, 2009.
C. Tan, H. Song, J. Niemi, and L. You.
A synthetic biology challenge: making cells compute.
Molecular BioSystems, 2007.
- C. Tan, S. Saurabh, M. Bruchez, R. Schwartz, and P. LeDuc.