Luis G Carvajal-Carmona

image of Luis G Carvajal-Carmona

Associate Professor

Departments

UC Davis Genome Center
Biochemistry and Molecular Medicine

Offices and Labs

GBSF, 451 Health Science Drive, Davis, CA 95616-8816
+1 530 752 9654

Degrees

2003 Ph.D. Genetics University College London (UK)
1998 B.Sc. Animal Science Universidad Nacional (Colombia)

Research Contribution

We have discovered several loci that increase the risk of colorectal tumors using genome-wide association studies, linkage analysis and next generation sequencing. These findings have been important because they are paving the way for future personalized prevention programs for this common form of cancer. We have also made important contributions to the study of Hispanic populations in the Americas and used genetic markers, for the fist time, to show that Hispanics descend from asymmetric patterns of admixture that mostly involved European men and local Native American (Amerindian) women.

Research Interests

Human and cancer genetics, Human genomics

We identify loci associated with increased risk of common cancers in humans. We have interests in functional genomics, genetic epidemiology and on how cancer somatic pathways vary across ethnic groups. We have a particular interests in the genetics and epidemiology of cancer in minority populations and have ongoing studies in several patient cohorts from Latin America. We apply a number of methods to identify cancer genes including genome-wide association studies, admixture mapping, linkage analysis and candidate gene approaches. We are increasingly using next generation sequencing in our studies and are shifting our focus from common to rare variant studies in families and population isolates

Awards

2012. Distinguished Alumni. BSc Animal Science (50th anniversary), Universidad Nacional de Colombia.
2011. Semi-finalist. Trainee Research Award, American Society for Human Genetics for abstract submission to the 12th International Congress of Human Genetics. Montreal, Canada
2009. Winner of the Divisional Research Prize. Medical Sciences Division, University of Oxford.
2009. Finalist. Neel Award for Young Investigators. International Genetic Epidemiology Society.
2008. Winner of the European Association for Cancer Research 40th Anniversary Research Award.
2004. Research Fellowship. London Research Institute, United Kingdom
2013. V Foundation V Scholar Award
2014. Latino Aging Research Resource Center Scholar
2014. K12 Paul Calabresi Career Development for Clinical Oncology K12 Scholar

Department and Center Affiliations

Department of Biochemistry and Molecular Medicine, School of Medicine
UC Davis Genome Center
UC Davis Comprehensive Cancer Center

ProfessionalSocieties

American Association for Cancer Research
American Thyroid Association
American Society for Human Genetics
British Association for Cancer Research
European Association for Cancer Research
Genetics Society (UK)
International Genetic Epidemiology Society

CBS Grad Group Affiliations

Integrated Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology
Molecular, Cellular, and Integrative Physiology

Specialties / Focus

Integrated Genetics and Genomics
  • Human Genetics and Genomics

Graduate Groups not Housed in CBS

Designated Emphasis in Biotechnology Program

Labs

Carvajal Carmona Lab website
  • Ted Toal, PhD, Postdoctoral Fellow
  • Paul Lott, PhD, Postdoctoral Fellow
  • Nicole Coggins, BSc, Graduate student (MCIP)
  • Ruta Sahasrabudhe, PhD, Postdoctoral Fellow
  • Guadalupe Carvajal, MSc, Associate Specialist
  • Jacob Stultz, BSc, Junior Specialist

Publications

2/3/2015 11:51:19 AM
  • Carvajal-Carmona LG, O'Mara TA, Painter JN, Lose FA, Dennis J, Michailidou K, Tyrer JP, Ahmed S, Ferguson K, Healey CS, Pooley K, Beesley J, Cheng T, Jones A, Howarth K, Martin L, Gorman M, Hodgson S; National Study of Endometrial Cancer Genetics Group (NSECG); Australian National Endometrial Cancer Study Group (ANECS), Wentzensen N, Fasching PA, Hein A, Beckmann MW, Renner SP, Dörk T, Hillemanns P, Dürst M, Runnebaum I, Lambrechts D, Coenegrachts L, Schrauwen S, Amant F, Winterhoff B, Dowdy SC, Goode EL, Teoman A, Salvesen HB, Trovik J, Njolstad TS, Werner HM, Scott RJ, Ashton K, Proietto T, Otton G, Wersäll O, Mints M, Tham E; RENDOCAS, Hall P, Czene K, Liu J, Li J, Hopper JL, Southey MC; Australian Ovarian Cancer Study (AOCS), Ekici AB, Ruebner M, Johnson N, Peto J, Burwinkel B, Marme F, Brenner H, Dieffenbach AK, Meindl A, Brauch H; GENICA Network, Lindblom A, Depreeuw J, Moisse M, Chang-Claude J, Rudolph A, Couch FJ, Olson JE, Giles GG, Bruinsma F, Cunningham JM, Fridley BL, Børresen-Dale AL, Kristensen VN, Cox A, Swerdlow AJ, Orr N, Bolla MK, Wang Q, Weber RP, Chen Z, Shah M, Pharoah PD, Dunning AM, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ.  Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.  Human Genetics 2015 Feb;134(2):231-45. doi: 10.1007/s00439-014-1515-4. Epub 2014 Dec 9.

  • Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, Tsung K, John EM, Torres-Mejia G, Carvajal-Carmona L, Echeverry MM, Tuazon AM, Ramirez C; COLUMBUS Consortium, Gignoux CR, Eng C, Gonzalez-Burchard E, Henderson B, Le Marchand L, Kooperberg C, Hou L, Agalliu I, Kraft P, Lindström S, Perez-Stable EJ, Haiman CA, Ziv E. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.  Nature Communications2014 Oct 20;5:5260. doi: 10.1038/ncomms6260

  • Wang J, Carvajal-Carmona LG, Chu JH, Zauber AG; APC Trial Collaborators, Kubo M, Matsuda K, Dunlop M, Houlston RS, Sieber O, Lipton L, Gibbs P, Martin NG, Montgomery GW, Young J, Baird PN, Ratain MJ, Nakamura Y, Weiss ST, Tomlinson I, Bertagnolli MM. Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study. Clinical Cancer Research013 Dec 1;19(23):6430-7. doi: 10.1158/1078-0432.CCR-13-0550. Epub 2013 Oct 1.

  • Carvajal-Carmona LG, Zauber AG, Jones AM, Howarth K, Wang J, Cheng T, APC Trail Collaborators, APPROVe Trail Collaborators, CORGI Study Collaborators, Colon Cancer Family Registry Collaborators, Riddell R, Lanas A, Morton D, Bertagnolli MM, Tomlinson IPM. Much of the population genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. Gastroenterology, 2013, 144:53-55.

  • Palles, C., Cazier, J., Howarth, K.M., Domingo, E., Jones, A.M., Broderick, P., Kemp, Z., Spain, S., Almeida, E., Salguero, I., Sherborne, A., Chuub, D., Carvajal-Carmona, L.G., Ma, Y., Kaur, K., Dobbins, S., Barclay, E., Gorman, M., Martin, L., Kovac, M., Humphray, S., Lucassen, A., Holmes, C., Bentley, D., Donnelly, P., Taylor, J., Petridis, C., Roylance, R., Sawyer, E., Kerr, D., Clark, S., Grimes, J., Kearsey, S., Thomas, H., McVean, G., Houlston, R., and Tomlinson, I. (2013). Germline mutations in POLE and POLD1 affecting the proofreading domains predispose to colorectal adenomas and carcinomas. Nature Genetics. 2013, 45(2): 136-144. See also the News and Views: Seshagiri, S. The burden of faulty proofreading in colon cancer, Nature Genetics, 2013, 45:121-124

  • Dunlop, MG, Dobbins SE, Farrington SM, Jones AM, Palles C, Whiffin N, Tenesa A, Spain S, Broderick P, Ooi LY,Domingo E, Smillie C, Henrion M, Frampton M, Martin L, Grimes G, Gorman M, Semple C, Ma YP, Barclay E, Prendergast J, Cazier J-B, Olver B, Penegar S, Lubbe S, Chander I, Carvajal-Carmona LG, Ballereau s, Lloyd A, Vijayakrishnan J, Zgaga L, Rudan I, Theodoratou E, Starr JM, Deary I, Kirac I, Kovacević D, Aaltonen LA, Renkonen-Sinisalo L, Mecklin j-P, Matsuda K, Nakamura Y, Okada Y, Gallinger S, Duggan DJ, Conti D, Newcomb P, Hopper J, Jenkins MA, Schumacher F, Casey G, Easton D, Shah M, Pharoah P, Lindblom A, Liu T, Smith CG, West H, Cheadle JP, Midgley R, Kerr DJ, Campbell H, Tomlinson IP, Houlston RS. Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nature Genetics, 2012, 44: 770-776.

  • Jones AM, Howarth KM, Martin L, Gorman M, Mihai R, Moss L, Auton A, Lemon C, Mehanna H, Mohan H, Clarke SEM, Wadsley J, Macias E, Coatesworth A, Beasley M, Roques T, Martin C, Ryan P, Gerrard G, Power D, Bremmer C, The TCUKIN Consortium, Tomlinson I, Carvajal-Carmona LG‡. Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24. Journal of Medical Genetics. 2012, 49:158-163.

  • Jones AM, Beggs AD, Carvajal-Carmona L, Walker M, Howarth K, Farrington S, Tenesa A, Ballereau S, Campbell H, Zauber A, Bertagnolli M, Kerr D, Hodgson SV, Dunlop M, Tomlinson I: TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut, 2012, 61:248-254.

  • Carvajal-Carmona LG‡, Cazier J-B, Jones A, Howarth K, Broderick P, Pittman A, Dobbins S, Tenesa A, Farrington S, Prendergast J, Theodoratou E, Barnetson R, Conti D, Newcomb P, Hopper JL, Jenkins MA, Gallinger S, Zanke B, Duggan DJ, Kerr D, Campbell H, Casey G, Houlston R, Dunlop M, Tomlinson I. Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11 refines regional association signals and in silico analyses suggests functional variation and identifies unexpected candidate target genes. Human Molecular Genetics, 2011, 20 (14): 2879-2888.

  • Tomlinson IPM, Carvajal-Carmona LG*, Dobbins SE, Tenesa A, Jones A, Howarth K, Palles C, Broderick P, Jaeger EM, Farrington S, Lewis A, Prendergast JG, Pittman AM, Theodoratou E, Olver B, Barnetson RA, Penegar S, Barclay E, Whiffin N, Martin L, Lloyd A, Gorman M, The COGENT Consortium, The CORGI collaborators, Ruiz-Ponte C, Fernandez-Rozadilla C, Castells A, Carracedo A, Castellvi-Bel S, Duggan D, Conti D, Cazier J-B, Kerr DK, Campbell H, Sieber O, Lipton L, Gibbs P, Montgomery G, Young J, Baird P, Zanke B, Gallinger S, Newcomb P, Hopper J, Jenkins MA, Aaltonen LA, Cheadle J, Pharoah P, Casey G, Dunlop MG, Houlston RS. The GREM1, BMP4 and BMP2 loci harbor multiple common susceptibility variants for colorectal cancer. PLOS Genetics, 2011, 7: e1002105.

  • Carvajal-Carmona, LG: Genetic dissection of intermediate phenotypes as a way to discover novel cancer susceptibility alleles. Current Opinions in Genetics and Development, 2010, 20:308–314.

  • Carvajal-Carmona LG: Challenges in the identification and use of rare disease-associated predisposition variants. Current Opinions in Genetics and Development, 2010, 20:227–281

  • Carvajal-Carmona LG‡, Churchman M, Bonilla C, Walther A, Lefevre J, Kerr D, Dunlop M, Houlston R, Bodmer W, Tomlinson I: Comprehensive assessment of variation at the Transforming Growth Factor Beta Type I Receptor locus and colorectal cancer predisposition. Procedings of the National Academy of Science USA, 2010, 107(17): 7858-7862