|2008||Ph.D.||Genetics||University of Chicago|
|2000||B.A.||Liberal Arts||Sarah Lawrence College|
Evolution of development
Our research focuses on how genetic variation in translated through the developmental process into phenotypes, and how these phenotypes evolve. The importance of sequence changes that affect development to morphological evolution has been well established. But the phenotypic consequences of mutations that alter developmental regulators are often muted by the systems that buffer development against variation encountered in ontogeny. By studying the relationship between mutation and developmental phenotype, we gain insight into both the molecular forces that drive and constrain phenotypic evolution and the systems that keep development robust. To pursue these questions, we use a combination of genetic, genomic, computational, and imaging techniques, primarily in the model system of Drosophila.
CBS Grad Group Affiliations
Specialties / Focus
- Animal Genomics
- Genomics, Proteomics and Metabolomics
- Signal Transduction and Gene Regulation
Lott SE, Villalta JE, Zhou Q, Bachtrog D, Eisen MB. (2014) Sex-specific embryonic gene expression in species with newly evolved sex chromosomes. PLoS Genet 10(2): e1004159.
Paris M, Kaplan T, Li X.-Y, Villalta J.E, Lott SE, Eisen MB (2013) Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression. PLoS Genetics. 9(9):e1003748.
Ali-Murthy Z, Lott SE, Eisen MB, Kornberg TB. (2013) An Essential Role for Zygotic Expression in the Pre-Cellular Drosophila Embryo. PLoS Genetics. 9(4): e1003428.
Lott SE, Viallalta JE, Schroth GP, Luo S, Tonkin LA, Eisen MB. (2011) Non-canonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seq. PLoS Biology 9(2): e1000590.
Lott SE, Ludwig MZ, Kreitman M. (2011) Evolution and genetic analysis of early embryonic patterning in D. simulans and D. sechellia. Evolution. May;65(5):1388-99.
Miles CM, Lott SE, Luengo Hendriks CL, Ludwig MZ, Manu, Williams CL, Kreitman M. Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster. (2010) Evolution. Jan;65(1):33-42.
Lott S.E., Kreitman M, Palsson A, Alekseeva E, Ludwig MZ. Canalization of segmentation and its evolution in Drosophila. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10926-31.