Offices and Labs
|2003||PhD||Neurobiology||University of Puerto Rico|
|1998||BS||General Science||University of Puerto Rico|
Cellular and molecular mechanisms regulating arterial smooth muscle excitability
The main goal of my research team is to understand the mechanisms by which local and global calcium signals regulate excitation-contraction coupling and excitation-transcription coupling in arterial smooth muscle cells during physiological and pathological conditions. To tackle these issues, we employ several state-of-the-art techniques including molecular biology, patch-clamp electrophysiology, super-resolution microscopy and confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. We are currently interested in determine the mechanisms by which hyperglycemia induces the activation of a novel calcium signaling modality (e.g. persistent calcium sparklets) in arterial smooth muscle, causing increased contraction and consequently, arterial dysfunction during diabetes.
CBS Grad Group Affiliations
Specialties / Focus
- Cellular Physiology
- Molecular Physiology
- Systemic Physiology
Graduate Groups not Housed in CBS
Madeline Nieves-Cintron - Research Scientist
Maria Paz Prada, Graduate student
Arsalan Y. Syed
Debapriya Ghosh, Postdoctoral Fellow
MA Nystoriak, M Nieves-Cintrón, T Patriarchi, S Morotti, E Grandi, J Dos Santos Fernandes, K Forbush, F Hofmann, KC Sasse, JD Scott, SM Ward, JW Hell, MF Navedo (2017) Ser1928 phosphorylation by PKA stimulates L-type Cav1.2 channels and vasoconstriction during acute hyperglycemia and diabetes. Science Signaling 10, eaaf9647. This article was highlighted in the cover and podcast of the journal and by Faculty of 1000. PMC5297430
H Qian, T Patriarchi, JL Price, L Matt, B Lee, M Nieves-Cintron, OR Buonarati, D Chowdhury, E Nanou, MA Nystoriak, WA Catterall, M Poomvanicha, F Hofmann, MF Navedo*, and JW Hell* (2017) Phosphorylation of serine 1928 mediates up-regulation of L-type Cav1.2 channel activity by β2 adrenergic receptor in neurons. Science Signaling 10, eaaf9659. *co-corresponding author. This article was highlighted in the cover and podcast of the journal and by Faculty of 1000. PMC5310946
RE Dixon, C Moreno, C Yuan, X Optiz-Araya, M Binder, MF Navedo* LF Santana* (2015) Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. eLife 4. *co-corresponding author.
M Nieves-Cintrón, MA Nystoriak, MP Prada, K Johnson, W Fayer, ML Dell’Acqua, JD Scott, MF Navedo (2015) Selective downregulation of KV2.1 function contributes to enhanced arterial tone during diabetes. JBC 290: 7918-7929.
MA Nystoriak, M Nieves-Cintrón, PJ Nygren, SA Hinke, CB Nichols, CY Chen, JL Puglisi, L Izu, DM Bers, ML Dell'Acqua, JD Scott, LF Santana, MF Navedo (2014) AKAP150 contributes to enhanced vascular tone by facilitating BKCa channel remodeling in hyperglycemia and diabetes. Circulation Research 114: 607-615. This article is accompanied by an editorial highlighting the novel aspects of the study. PMC3954117.