Manuel Navedo

image of Manuel Navedo



Pharmacology - Medicine

Offices and Labs

Tupper Hall 2420



2003 PhD Neurobiology University of Puerto Rico
1998 BS General Science University of Puerto Rico

Research Interests

Cellular and molecular mechanisms regulating arterial smooth muscle excitability

The main goal of my research team is to understand the mechanisms by which local and global calcium signals regulate excitation-contraction coupling and excitation-transcription coupling in arterial smooth muscle cells during physiological and pathological conditions. To tackle these issues, we employ several state-of-the-art techniques including molecular biology, patch-clamp electrophysiology, super-resolution microscopy and confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. We are currently interested in determine the mechanisms by which hyperglycemia induces the activation of a novel calcium signaling modality (e.g. persistent calcium sparklets) in arterial smooth muscle, causing increased contraction and consequently, arterial dysfunction during diabetes.


2007 AHA - Scientist Development Award
2015 National Institutes of Health – Early Career Reviewer Program Alumni
2016-2022 Charter Member NIH VCMB Study Section
2016 UCD Academic Senate Research Travel Award


Biophysical Society
American Physiological Society
American Heart Association

CBS Grad Group Affiliations

Molecular, Cellular, and Integrative Physiology

Specialties / Focus

Molecular, Cellular, and Integrative Physiology
  • Cellular Physiology
  • Molecular Physiology
  • Neurophysiology
  • Systemic Physiology

Graduate Groups not Housed in CBS

Pharmacology and Toxicology Graduate Group


Navedo Lab
  • Madeline Nieves-Cintron - Research Scientist
  • Maria Paz Prada, Graduate student
  • Arsalan Y. Syed
  • Debapriya Ghosh, Postdoctoral Fellow

Teaching Interests

Introductory Biology, Molecular and Cellular Biology, Ion Channel Physiology and Pharmacology, Neurobiology, Physiology, Vascular Biology, Cardiovascular Physiology.


MCP 210C Integrative and comparative physiology (Spring)
MCP 290 Cellular and Integrative Cardiovascular Biology Journal Club (Fall, Winter, Spring)
PHA 208 Advanced cardiac physiology and pharmacology (Spring)
MCP, PTX 215 Electrophysiological and optical techniques to study ion channels (Spring)

Personal Interests

I enjoy hiking, camping, biking, reading, watching movies. website


  • MA Nystoriak, M Nieves-Cintrón, T Patriarchi, S Morotti, E Grandi, J Dos Santos Fernandes, K Forbush, F Hofmann, KC Sasse, JD Scott, SM Ward, JW Hell, MF Navedo (2017) Ser1928 phosphorylation by PKA stimulates L-type Cav1.2 channels and vasoconstriction during acute hyperglycemia and diabetes. Science Signaling 10, eaaf9647. This article was highlighted in the cover and podcast of the journal and by Faculty of 1000. PMC5297430

  • H Qian, T Patriarchi, JL Price, L Matt, B Lee, M Nieves-Cintron, OR Buonarati, D Chowdhury, E Nanou, MA Nystoriak, WA Catterall, M Poomvanicha, F Hofmann, MF Navedo*, and JW Hell* (2017) Phosphorylation of serine 1928 mediates up-regulation of L-type Cav1.2 channel activity by β2 adrenergic receptor in neurons. Science Signaling 10, eaaf9659. *co-corresponding author. This article was highlighted in the cover and podcast of the journal and by Faculty of 1000. PMC5310946

  • RE Dixon, C Moreno, C Yuan, X Optiz-Araya, M Binder, MF Navedo* LF Santana* (2015) Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. eLife 4. *co-corresponding author.

  • M Nieves-Cintrón, MA Nystoriak, MP Prada, K Johnson, W Fayer, ML Dell’Acqua, JD Scott, MF Navedo (2015) Selective downregulation of KV2.1 function contributes to enhanced arterial tone during diabetes. JBC 290: 7918-7929.

  • MA Nystoriak, M Nieves-Cintrón, PJ Nygren, SA Hinke, CB Nichols, CY Chen, JL Puglisi, L Izu, DM Bers, ML Dell'Acqua, JD Scott, LF Santana, MF Navedo (2014) AKAP150 contributes to enhanced vascular tone by facilitating BKCa channel remodeling in hyperglycemia and diabetes. Circulation Research 114: 607-615. This article is accompanied by an editorial highlighting the novel aspects of the study. PMC3954117.