Nadean Brown

image of Nadean Brown

Professor

Departments

Cell Biol & Human Anatomy

Offices and Labs

4407A Tupper Hall
530-752-7806
4407/4416 Tupper Hall
530-752-8359
530-752-8354

Degrees

1994 PhD Cell & Molecular Biology University of Wisconsin

Research Interests

Mammalian Developmental Genetics

My research group aims to understand the molecular mechanisms regulating the formation of the mammalian lens and retina. We are investigating the genetic pathways underlying lens and retinal tissue formation during embryogenesis. This research will contribute to a better understanding of congenital eye diseases and ultimately inform therapies that can correct vision loss. Currently we are focused on understanding: 1) how lens progenitor cells stop dividing and turn into fiber cells, 2) how retinal progenitor cells choose to become one type of neuron, although multiple fates are available to them and 3) the role of the optic nerve head in patterning the retina.

Awards

1995-96 NRSA Postdoctoral Research Fellowship
1995 NSF Postdoctoral Fellowship (declined)
1996 Cold Spring Harbor Laboratory Course "Molecular Embryology of the Mouse" Participant
2014 Visual Systems Development Gordon Conference Vice Chair
2016 Visual Systems Developement Gordon Conference Chair

Department and Center Affiliations

UC Davis Center for Vision Sciences
UC Davis Comprehensive Cancer Center

ProfessionalSocieties

Genetics Society of America
Society for Developmental Biology
Society for Neuroscience
International Society for Eye Research
Association for Research in Vision and Ophthalmology

CBS Grad Group Affiliations

Integrated Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine
  • Biochemistry
  • Molecular Genetics
  • Developmental Biology
  • Gene Regulation
  • Signal Transduction
  • Vision
Integrated Genetics and Genomics
  • Developmental Genetics
  • Model Organism Genetics

Labs

Mina Azimi, BMCDB Graduate Student
Angelica Kowalchuck, GGG Graduate Student
Joel Miesfeld, Postdoctoral Fellow
Bernadett Bosze, Postdoctoral Fellow

Courses

Cell Biol CH402 Cell & Tissue Biology

Publications

10/28/2014 4:06:54 PM
  • A.N. Riesenberg, and N.L. Brown (2016) Cell autonomous and nonautonomous requirements
    for Delltalike1 during early mouse retinal neurogenesis. Developmental Dynamics 245(6):631-40.

  • Maurer, KA, A.N. Riesenberg, and N.L. Brown (2014) Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development 141: 3243-3254.

  • Hufnagel, R.B., A.N. Riesenberg, J.A. Brzezinski IV, M. Quinn, T. Glaser and N.L. Brown. (2013) Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Molecular and Cellular Neuroscience. 54: 108-120.
  • Hufnagel, R.B. and N.L. Brown (2013). “Specification of Retinal Cell Types” in Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience; Editors, John Rubenstein and Pasko Rakic. Elsevier: pp 519-537.
  • Saravanamuthu, S.S., T.T. Le, C.Y. Gao, C. Liu, C. Radu, P. Pandiyan, J. Zhang, P.S. Zelenka and N.L. Brown. (2012) Conditional ablation of the Notch2 receptor in the ocular lens. Developmental Biology 362: 219-29.
  • Le, T.T., K. Conley, T.J. Mead, S. Rowan, K.E. Yutzey and N.L. Brown. (2012) Requirements for Jag1-Rbpj mediated Notch signaling during mouse lens vesicle development. Developmental Dynamics 241: 493-504
  • Charlton-Perkins, M., N.L. Brown, and T.A. Cook (2011). The Lens in Focus: A Comparison of Lens Development in Drosophila and Vertebrates. Molecular Genetics & Genomics 286: 189-213.
  • Prasov, L, Brown, NL and Glaser, T. (2010) A critical analysis of Atoh7 (Math5) splicing in the developing mouse retina. PLoS One. 2010; Aug 5(8):e12315.
  • Macgregor S, Hewitt AW, Hysi PG, Ruddle JB,Medland SE, Henders AK, Gordon SD, Andrew T, McEvoy B, Sanfilippo PG, Carbonaro F, Tah V, Li YJ, Bennett SL, Craig JE, Montgomery GW, Tran-Viet KN, Brown NL, Spector TD, Martin NG, Young TL, Hammond CJ, Mackey DA. (2010) Genome-wide association identifies ATOH7 as a major gene determining human optic nerve size. Human Molecular Genetics. 340: 490-503.
  • Hufnagel RB, Le TT, Riesenberg AL, Brown NL. (2010) Neurog2 controls the leading edge of neurogenesis in the mammalian retina. Developmental Biology 340: 490-503.
  • Riesenberg AN, Liu Z, Kopan R, Brown NL. (2009) Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. Journal of Neuroscience 29: 12865-77.
  • Riesenberg AN, Le TT, Willardsen MI, Blackburn DC, Vetter ML, Brown NL. (2009) Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis 47:175-187.
  • Le TT, Conley K, Brown NL. (2009) Jagged1 is necessary for normal mouse lens development. Developmental Biology 328:118-126.
  • Willardsen MI, Suli A, Pan Y, Marsh-Armstrong N, El-Hodiri H, Chen CB, Moore KB, Brown NL, Vetter ML. (2009) Temporal regulation of Ath5 gene expression during eye development. Developmental Biology 326:471-481.
  • Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. (2009) Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophth Vis Sci. 50:432-440.