James Hildreth

image of James Hildreth



Molecular & Cellular Biology

Offices and Labs

207 Life Sciences
+1 530 752 6778


1987 MD Medicine Johns Hopkins University
1982 PhD Immunology Oxford University
1979 BA Chemistry Harvard University

Research Interests

My laboratory research is focused on understanding mechanisms by which HIV subverts host pathways and molecules during its replication cycle. We are particularly interested in the role of cholesterol and cholesterol homeostatic pathways in virus entry, virus release and viral gene transcription. The involvement of cholesterol-rich lipid rafts, late endosomes and exosomes is also the subject of investigations in our laboratory. Another major area of interest is the impact of viral co-infections on HIV’s tropism and replication. Many viruses are known to modulate cholesterol regulatory pathways and cellular cholesterol content and thereby can profoundly affect HIV replication. We are interested in this and other mechanisms of enhancement or suppression of HIV transmission and replication by co-infecting viruses.


Rhodes Scholar
Alpha Omega Alpha
NSF Presidential Young Investigator
Institute of Medicine
NIH Director’s Pioneer Award


American Society of Microbiology

CBS Grad Group Affiliations

Integrated Genetics and Genomics

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine


3/4/2015 1:25:19 PM
  • Wang Z1, Luo Y1, Shao Q1, Kinlock BL1, Wang C2, Hildreth JE1, Xie H3, Liu B1. Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication. PLoS One. 2014 Aug 28;9(8):e106078. doi: 10.1371/journal.pone.0106078. eCollection 2014.
  • Tang Y, George A, Nouvet F, Sweet S, Emeagwali N, Taylor HE, Simmons G, HILDRETH, JE. Infection of female primary lower genital tract epithelial cells after natural pseudotyping of HIV-1: possible implications for sexual transmission of HIV-1. PLoS One. 2014 Jul 10;9(7):e101367. doi: 10.1371/journal.pone.0101367. eCollection 2014.
  • Linde, ME, Colquhoun, DR, Ubaida Mahien C, Kole, T, Aquino, V, Cotter, R, Edwards, N, HILDRETH, JE, Graham DR. The conserved set of proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types. J Proteome Res 2013 May 3; 12(5):2045-54. PMID 23432411
  • Armstrong, A., HILDRETH, J.E., Amzel, L.M. Structural and thermodynamic insights into the recognition of native proteins by anti-peptide antibodies. J Mol Biol 2013 Jun 12;425(11):2027-38. PMID: 23473830.
  • Zamani, C., Elzey, HILDRETH, JEK. Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine. HIV AIDS (Auckl) 2013 Apr 12;5:75-80.
  • Emeagwali, N., HILDRETH, JEK. Human Immunodeficiency Virus Type 1 Vpu and Cellular TASK Proteins Suppress Transcription of Unintegrated HIV-1 DNA. Virol. J. 2012 November 19; 9:277.
  • Tang, Y, George, A, Taylor, T, HILDRETH, JEK. Cholesterol depletion inactivates XMRV and leads to viral envelope protein release from virions: evidence for role of cholesterol in XMRV infection. PLoS ONE 2012 Oct 26; 7(10): e48013. doi: 10.1371/journal.pone.0048013
  • Walker, TM, Cimakasky, LM, Coleman, EM, Madison, MN, HILDRETH, JEK. Antibody Against Integrin LFA-1 Inhibits HIV-1 Infection in Primary Cells through Caspase 8-Mediated Apoptosis. AIDS Res Hum Retroviruses 2012, August 20; [ePub ahead of print].
  • Simmons, GE, Taylor, HE, HILDRETH, JEK. Caveolin-1 suppresses human immunodeficiency virus-1 replication by inhibiting acetylation of NFκB. Virology 2012, http://dx.doi.org/10.1016/j.virol.2012.05.016
  • Montgomery Rice, V, Maimbolwa, MC, Munalula Nkandu, E, Hampton, JF, Lee, JE, HILDRETH, JEK. Cultural differences in acceptability of a vaginal microbicide: a comparison between potential users from Nashville, Tennessee, USA, and Kafue and Mumbwa, Zambia. HIV/AIDS Research and Palliative Care, 2012 May 8; 4: 73–80.
  • Coleman EM, Walker TN, HILDRETH, JEK. Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes. Virol J. 2012 Jan 24;9:31. PMID: 22273177
  • Cooper J, Liu L, Woodruff EA, Taylor HE, Goodwin JS, D'Aquila RT, Spearman P, HILDRETH JE, Dong X. Filamin a interacts with human immunodeficiency virus type 1gag and contributes to productive particle assembly. J Biol Chem. 2011 Aug 12; 286(32): 28498-510 [Epub 2011 Jun 24] PubMed PMID: 21705339.
  • Taylor HE, Linde ME, Khatua AK, Popik W, Hildreth JE. Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol. 2011 Aug;85(15):7699-709. Epub 2011 May 25. PubMed PMID: 21613400.
  • Shao Q, Wang Y, Hildreth JE, Liu B. Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif. J Virol. 2010 May;84(9):4840-4. Epub 2010 Feb 10. PubMed PMID: 20147392; PubMed Central PMCID: PMC2863731.
  • Khatua AK, Taylor HE, Hildreth JE, Popik W. Non-productive HIV-1 infection of human glomerular and urinary podocytes. Virology. 2010 Dec 5;408(1):119-27. PubMed PMID: 20937511; PubMed Central PMCID: PMC2970920.
  • Atanu K. Khatua, Harry E. Taylor, James E.K. Hildreth, Waldemar Popik (2010) Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F. Virology 2010 Dec 5; 408(1): 119-27 Epub 11 February 2010 PMCID 20937511