James Hildreth

image of James Hildreth

Dean

Departments

Molecular & Cellular Biology

Offices and Labs

207 Life Sciences
+1 530 752 6764

Degrees

1987 MD Medicine Johns Hopkins University
1982 PhD Immunology Oxford University
1979 BA Chemistry Harvard University

Research Interests

My laboratory research is focused on understanding mechanisms by which HIV subverts host pathways and molecules during its replication cycle. We are particularly interested in the role of cholesterol and cholesterol homeostatic pathways in virus entry, virus release and viral gene transcription. The involvement of cholesterol-rich lipid rafts, late endosomes and exosomes is also the subject of investigations in our laboratory. Another major area of interest is the impact of viral co-infections on HIV’s tropism and replication. Many viruses are known to modulate cholesterol regulatory pathways and cellular cholesterol content and thereby can profoundly affect HIV replication. We are interested in this and other mechanisms of enhancement or suppression of HIV transmission and replication by co-infecting viruses.

Awards

Rhodes Scholar
Alpha Omega Alpha
NSF Presidential Young Investigator
Institute of Medicine
NIH Director’s Pioneer Award

ProfessionalSocieties

American Society of Microbiology

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology
Integrated Genetics and Genomics
Molecular, Cellular, and Integrative Physiology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine

Publications

9/29/2011 11:16:36 AM
  • Cooper J, Liu L, Woodruff EA, Taylor HE, Goodwin JS, D'Aquila RT, Spearman P, Hildreth JE, Dong X. (2011). Filamin a interacts with human immunodeficiency virus type 1gag and contributes to productive particle assembly. J Biol Chem. 286(32):28498-510. PMID: 21705339
  • Taylor HE, Linde ME, Khatua AK, Popik W, Hildreth JE. (2011). Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol. 85(15):7699-709. PMID: 21613400
  • Shao Q, Wang Y, Hildreth JE, Liu B. (2010). Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif. J Virol. 2010. 84(9):4840-4. PMID: 20147392
  • Khatua AK, Taylor HE, Hildreth JE, Popik W. (2010). Non-productive HIV-1 infection of human glomerular and urinary podocytes. Virology. 408(1):119-27. PMID: 20937511
  • Atanu K. Khatua, Harry E. Taylor, James E.K. Hildreth, Waldemar Popik. (2010). Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F. Virology. 400(1):68-75
  • Tang Y, Leao IC, Coleman EM, Broughton RS, Hildreth JE. (2009). Deficiency of Niemann-Pick type C-1 Protein Impairs HIV-1 Release and Results in Gag Accumulation in Late Endosomal/Lysosomal Compartments. J Virol. 83(16):7982-95
  • Khatua AK, Taylor HE, Hildreth JE, Popik W. (2009). Exosomes packaging APOBEC3G confer HIV-1 resistance to recipient cells. J Virol. 83(2):512-2
  • Kitabwalla M, Ansari AA, Villinger F, Akeefe H, Conner AP, Mayne AE, Hildreth JE. (2008). Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment. Exp Biol Med (Maywood). 233(6):732-40
  • Nguyen, D.G., A.M. Booth, S.J. Gould, and J.E.K. HILDRETH. (2003). Evidence that HIV Budding in Primary Macrophages Utilizes the Exosome Release Pathway. J. Biol. Chem. 278(52):52347-54
  • Gould, S.J., A.M. Booth, and J.E.K. HILDRETH. (2003). The Trojan Exosome Hypothesis. Proc. Nat. Acad Sci USA 100:10592-10597
  • Graham, D.R., E. Chertova, J. Hilburn, L.O. Arthur, and J.E.K. HILDRETH. (2003). Cholesterol Depletion of HIV-1 and SIV with Beta-Cyclodextrin Inactivates and Permeabilizes the Virions: Evidence for Virion-Associated Lipid Rafts. J Virol 77:8237-8248
  • Liao, Z., D.R. Graham, and J.E.K. HILDRETH. (2003). Lipid Rafts and HIV-1 Pathogenesis Virion-Associated Cholesterol Is Required for Fusion and Infection of Susceptible Cells. AIDS Res Human Retroviruses 19:675-687
  • Khanna, K.V., KJ Whaley, L. Zeitlin, T.R. Moench, K. Mehrazar, R.A. Cone, Z. Liao, J.E.K. HILDRETH, T.E. Hoen, L. Shultz, and R.B. Markham. (2002). Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent. J Clin Invest. 109:205-11
  • Liao, Z., L. Cimakasky, D. Nguyen, R. Hampton, and J.E.K. HILDRETH. (2001). Lipid Rafts and HIV-1 Pathogenesis: Cholesterol is required for HIV-1 Infectivity. AIDS Res. Hum. Retroviruses 17:1009-1019