Yoshihiro Izumiya

image of Yoshihiro Izumiya

Asst Professor


Dermatology - Medicine

Offices and Labs

Research III Bldg/UCDMC Sacramento, CA 95817


2001 PhD Virology/Molecular Virology University of Tokyo
1997 BS/DVM Veterinary Medicine Kitasato University

Research Interests

Using herpesvirus reactivation as a model to study gene regulation

Epigenetic gene regulation by using herpesvirus reactivation as a model system. Epigenetic components of chromatin, including host and viral factors that interact to facilitate both the establishment and maintainance of the chromatin state as well as the molecular transitions that take place during reactivation (“chromatin remodeling”). Post-translational modifications that are imparted on critical viral and host factors are also an area of research in our lab.

Cancer biology and posttranslational protein modification

Protein methylases and demethylases that regulate breast cancer cell growth


Research Fellowships for Young Scientists of the Japan Society for Promotion of Science, 1998
Uehara Memorial Postdoctoral Fellowship, 2002
Universitywide AIDS Research Program Postdoctoral Fellowship Awards, 2003
Plenary Honors Japanese Veterinary Medical Science, 2003
Award for Excellence in Postdoctral Research at UC Davis, 2005
California HIV/AIDS Research IDEA Award, 2007
Amrican Cancer Society Research Scolar Award 2013

Department and Center Affiliations

UC Davis Cancer Center


American Society for Microbiology
The Japanese Society of Veterinary Science
The Japanese Society for Virology

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine


11/6/2015 3:14:39 PM
  • Kim KY, Wang DH, Campbell M, Huerta SB, Shevchenko B, Izumiya C, Izumiya Y. (2015) PRMT4-mediated Arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation. Mol Cell Biol, 35(1): 238-48.

  • Nakajima K, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M. (2015) KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun, 6: 8532. doi: 10.1038/ncomms9532

  • Campbell M, Kung HJ, Izumiya Y. (2014) Long non-coding RNA and epigenetic gene regulation of KSHV. Viruses, 6(11): 4165-4177.


  • Campbell M, Kim KY, Chang PC, Huerta S, Shevchenko B, Wang DH, Izumiya C, Kung HJ, Izumiya Y. (2014) A lytic viral long noncoding RNA modulates the function of a latent protein. J Virol, 88(3): 1843-1848.

  • Kim KY, Huerta SB, Izumiya C, Wang DH, Martinez A, Shevchenko, B, Kung HJ, Campbell M, Izumiya, Y. (2013) Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated nuclear antigen regulates KSHV epigenome by association with histone demethylase, KDM3A. J Virol 87(12): 6782-6793.

  • Datsun A. Hsia, Clifford G. Tepper, Mamata R. Pochampalli, Elaine Y.C. Hsia, Chie Izumiya, Steve B. Huerta, Michael E. Wright, Hong-Wu Chen, Hsing-Jien Kung, and Yoshihiro Izumiya* (2010) KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proceedings National Academy of Science 107: 9671-9676
  • Pei-Ching Chang, Yoshihiro Izumiya, Chun-Yi Wu, Latricia D. Fitzgerald, Mel Campbell, Thomas J. Ellison, Kit S. Lam, Paul A. Luciw, and Hsing-Jien Kung (2010) Kaposi's sarcoma associated herpesvirus (KSHV) encodes a SUMO E3 ligase which is SIM-dependent and SUMO-2/3-specific. Journal of Biological Chemistry 285: 5266-5273
  • Paulette F. Suchodolski#, Yoshihiro Izumiya#, Blanca Lupiani, Dharani K. Ajithdoss, Lucy F. Lee, Hsing-Jien Kung and Sanjay M. Reddy (2010) Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens. Virology 399: 312-321
  • Yoshihiro Izumiya*, Chie Izumiya, Datsun Hsia, Thomas J. Ellison, Paul A. Luciw, and Hsing-Jien Kung (2009) NF-kappa({kappa})B Serves as a Cellular Sensor of KSHV Latency and Negatively Regulates K-Rta by Antagonizing the RBP-J{kappa} Coactivator. Journal of Virology 83: 4435-4446
  • Thomas J. Ellison#, Yoshihiro Izumiya#*, Chie Izumiya, Paul A. Luciw, and Hsing-Jien Kung (2009) A Comprehensive Analysis of Recruitment and Transactivation Potential of K-Rta and K-bZIP during Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus. Virology 387: 76-88
  • Paulette F. Suchodolski#, Yoshihiro Izumiya#, Blanca Lupiani, Dharani K. Ajithdoss, Oren Gilad, Lucy F. Lee, Hsing-Jien Kung, and Sanjay M. Reddy (2009) Homodimerization of Marek's Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in Chickens. Journal of Virology 83: 859-869
  • Pei-Ching Chang, Latricia D. Fitzgerald, Albert Van Geelen, Yoshihiro Izumiya, Thomas J. Ellison, Don-Hong Wang, David K. Ann, Paul A. Luciw and Hsing-Jien Kung (2009) Kruppel-Associated Box Domain-Associated Protein-1 as a Latency Regulator for Kaposi's Sarcoma-Associated Herpesvirus and Its Modulation by the Viral Protein Kinase. Cancer Research 69: 5681-5689
  • Oliver Gautschi, Clifford G. Tepper, Phillip R. Purnell, Yoshihiro Izumiya, Christopher P. Evans, Tim P. Green, Pierre Y. Desprez, Primo N. Lara, David R. Gandara, Philip C. Mack, and Hsing-Jien Kung (2008) Regulation of Id1 Expression by Src: Implications for Targeting of the Bone Morphogenetic Protein Pathway in Cancer. Cancer Research 68: 2250-2258
  • Yoshihiro Izumiya, Chie Izumiya, Albert M. VanGeelen, Don-Hong Wang, Kit S. Lam, Paul A. Luciw, Hsing-Jien Kung (2007) Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. Journal of Virology 81: 1072-1082
  • Alon M. Levy, Oren Gilad, Liang Xia, Yoshihiro Izumiya, Jonathan Choi, Tsalenko A, Yakhini Z, Richard L. Witter, Lucy F. Lee, Carol J. Cardona, Hsing-Jien Kung. (2005) Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for Avian oncoviruses. Proceedings National Academy of Science 102:14831-14836
  • Yoshihiro Izumiya, Thomas J. Ellison, Edward T.H. Yeh, Jae U. Jung, Paul A. Luciw, Hsing-Jien Kung. (2005) Kaposi’s sarcoma-associated Herpesvirus K-bZIP represses gene transcription via SUMO modification. Journal of Virology 79:9912-9925