Barbara Shacklett

image of Barbara Shacklett

Professor

Departments

Microbiology - Medicine

Offices and Labs

Tupper Hall, Davis, CA 95616
+1 530 752 6785

Degrees

1999 Postdoctoral Fellowship Cellular Immunology Aaron Diamond AIDS Research Center, Rockefeller University, New York NY
1997 Postdoctoral Fellowship Molecular Virology Institut Cochin, Paris France
1994 PhD Microbiology University of California, Davis
1985 BS Microbiology Cook College, Rutgers University

Research Interests

HIV and Mucosal Immunity

Adaptive immune responses to HIV in the gastrointestinal and reproductive tracts. HIV pathogenesis. Mechanisms of immune control of HIV infection, and genetic determinants of HIV-specific immune responses.

Awards

Selman A. Waksman Award in Microbiology, Cook College, Rutgers University (1985)
Regents Predoctoral Fellowship, UC Davis (1988-1990)
Earle C. Anthony Predoctoral Fellowship, UC Davis (1990-1991)
Postdoctoral Fellowship, Agence Nationale de Recherches sur le SIDA (ANRS, Paris, France) (1994-1996)
Postdoctoral Fellowship, Fondation Pour la Recherche Medicale (SIDACTION, Paris, France) (1996-1997)

Department and Center Affiliations

Member, UC Davis Cancer Center

ProfessionalSocieties

Society for Mucosal Immunology
American Society for Microbiology
American Association of Immunologists
International AIDS Society
International Society for the Advancement of Cytometry

CBS Grad Group Affiliations

Integrated Genetics and Genomics

Graduate Groups not Housed in CBS

Immunology
Microbiology

Labs

Shacklett Lab/Tupper Hall 3324 website
  • April Ferre, PhD (Staff Researcher); Uma Shanmugasundaram, PhD (Postdoctoral Fellow); Brenna Kiniry, BS (Graduate Student, Microbiology); Anupama Ganesh, MS (Graduate Student, Immunology). Former Lab Personnel: Bill Critchfield, PhD (Asst Project Scientist); Donna Lemongello (SRA); Delandy McConnell (SRA); Graduate Students: Tim Hayes, Immunology; Julia Shaw, Microbiology; April Ferre, Microbiology; Aileen Espinoza, Immunology.
Visiting Scientists
  • Mohanakrishnan Janardhanan, YRG CARE laboratory, Chennai, India; Maire Quigley, Karolinska Institutet, Stockholm, Sweden; Alix Scholer, Ecole Normale Superieure, Paris, France.

Teaching Interests

Microbiology, Host-Pathogen Interactions, Virology, Mucosal Immunology, General and Clinical Immunology

Courses

IMM 297 Mucosal Immunology (Spring)
MMI 480A Medical Immunology (MD students only) (Winter)
MMI 200D Mechanisms for Microbial Interactions With Hosts (Winter)

Publications

12/9/2013 4:57:11 PM
  • 1) Ferre, A.L., Hunt, P., Critchfield, J.W., Young, D.H., Morris, M.M., Garcia, J.C., Pollard, R.B., Yee, H.F., Martin, J.N., Deeks, S.G., and Shacklett, B.L. (2009), Mucosal Immune Responses to HIV-1 in Elite Controllers: A Potential Correlate of Immune Control. Blood 113:3978-89. PMID: 19109229.
  • 2) Ferre, A.L., Lemongello, D., Morris, M.M., Schreiber, M.A., Garcia, J.C., Asmuth, D.M., Pollard, R.B., and Shacklett, B.L. (2010), Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers. Journal of Virology 84:10354-65. PMID:20668079.
  • 3) Ferre, A.L., Hunt, P.W., Critchfield, J.W., McConnell, D.H., Garcia, J.C., Pollard, R.B., Deeks, S.G., and Shacklett, B.L. (2010), HIV controllers with HLA-DRB1*13 and DQB1*06 have strong, polyfunctional mucosal CD4+ T-cell responses. Journal of Virology 84:11020-9. PMID: 20719952.
  • 4) Shaw, J.M., Hunt, P.W., Critchfield, J.W., McConnell, D.H., Garcia, J.C., Pollard, R.B., Somsouk, M., Deeks, S.G., and Shacklett, B.L., (2011), Increased frequency of regulatory T-cells accompanies increased T-cell immune activation in rectal mucosae of HIV+ non-controllers. Journal of Virology 85:11422-11434. PMID: 20880771.
  • 5) Hayes, T.L., Critchfield, J.W., Knight, T.H., McLaughlin, B.E., Yotter, T., McConnell, D.H., Garcia, J.C., Pollard, R.B., Asmuth, D.M., and Shacklett, B.L. (2013), Impact of HAART initiation on CD4+ T-cell repopulation in small and large intestinal mucosa. AIDS 27(6):867-877, PMID: 23262500.